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Preparation method of titanium surface porous structure layer bioactive ceramic membrane with low elasticity modulus

A technology of bioactive ceramics and low elastic modulus, applied in coatings, medical science, prostheses, etc., can solve the problems of unfavorable implants bearing load for a long time, high surface elastic modulus, chronic fatigue of bone tissue, etc. To achieve the effect of biological function, high strength and compression resistance, good nail anchoring and ossification

Inactive Publication Date: 2013-05-08
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology has the following problems: at the initial stage of implantation, the bone tissue has not yet formed a microscopic bond with the implant, and the elastic modulus of the pure titanium or titanium alloy surface is inconsistent with the elastic modulus of the bone tissue, that is, the problem of stress concentration remains, the effects of stress lead to chronic fatigue of bone tissue
However, this solution also brings the following problems: the inner surface of the pore structure inside the porous implant is difficult to process to form an oxide film, and under the condition of body fluid and load, the corrosion resistance of pure titanium or titanium alloy is poor, and the corrosion is relatively serious , it is easy to release metal ions to the body, which will adversely affect the health of the recipient; in addition, the strength of the porous structure implant itself is still lower than that of the solid structure implant, which is not conducive to the long-term load bearing of the implant
From this point of view, solid structure implants are still a better choice, but the problem of high surface elastic modulus of solid structure implants needs to be solved

Method used

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  • Preparation method of titanium surface porous structure layer bioactive ceramic membrane with low elasticity modulus
  • Preparation method of titanium surface porous structure layer bioactive ceramic membrane with low elasticity modulus
  • Preparation method of titanium surface porous structure layer bioactive ceramic membrane with low elasticity modulus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Pure titanium TC2 is selected as the solid structure of the implant

[0039] 2. Chemical degreasing:

[0040] Sodium hydroxide 50g / L, sodium phosphate 5g / L, the rest is water; temperature: 30°C; time 5 minutes;

[0041] 3. Pickling:

[0042] 70% (volume concentration) HNO 3 10ml / L, citric acid 5g / L, and the rest is water. Temperature: room temperature, process for 2 minutes, wash with tap water for 1 to 2 minutes immediately after taking it out, and then wash with deionized water for 1 to 2 minutes.

[0043] 4. Preparation of porous layer by powder metallurgy method:

[0044] The pure titanium powder and urea powder are mixed, the average particle size of the pure titanium is 30 microns, the urea powder is used as a space support, and the particle size of the urea powder is 50 microns. The ratio of pure titanium to urea powder is determined according to the porosity of the porous structure layer to be obtained, and the porosity is preferably 50%. The pure titan...

Embodiment 2

[0060] 1. Pure titanium TC4 is selected as the solid structure of the implant

[0061] 2. Chemical degreasing:

[0062] Sodium hydroxide 50g / L, sodium phosphate 5g / L, the rest is water; temperature: 30°C; time 5 minutes;

[0063] 3. Pickling:

[0064] 40% (volume concentration) HF4ml / L, 95% (volume concentration) H 2 SO 4 10ml / L, tartaric acid 10g / L, and the rest is water. Temperature: room temperature, process for 2 minutes, wash with tap water for 1 minute immediately after taking it out, and then wash with deionized water for 1 minute, the thickness of the passivation film is 1 μm.

[0065] 4. Preparation of porous layer by powder metallurgy method:

[0066] The pure titanium powder and urea powder are mixed, the average particle size of the pure titanium is 30 microns, the urea powder is used as a space support, and the particle size of the urea powder is 80 microns. The ratio of pure titanium to urea powder is determined according to the porosity of the porous struc...

Embodiment 3

[0081] 1. Ti6Al4V is selected as the solid structure of the implant

[0082] 2. Chemical degreasing:

[0083] Sodium hydroxide 50g / L, sodium phosphate 5g / L, the rest is water; temperature: 30°C; time 5 minutes;

[0084] 3. Pickling:

[0085] 70% (volume concentration) HNO 3 4ml / L, 95% (volume concentration) H 2 SO 4 8ml / L, oxalic acid 5g / L, and the rest is water. Temperature: room temperature, treat for 3 minutes, wash with tap water for 1 minute after taking it out, and then wash with deionized water for 1 minute, the thickness of the passivation film is 1 μm.

[0086] 4. Preparation of porous layer by powder metallurgy method:

[0087] Mix pure titanium powder and urea powder, the average particle size of pure titanium is 40 microns, urea powder is used as a space support, the particle size of urea powder is 70 microns, the ratio of titanium alloy to urea powder can be obtained as required The porosity of the porous structure layer is determined, and the porosity is p...

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Abstract

The invention discloses a preparation method of a titanium surface porous structure layer bioactive ceramic membrane with low elasticity modulus, and relates to the field of biomedical implant, especially the preparation technology of a biomedical implant made of a titanium or titanium alloy material. The method comprises steps of: first preparing a porous structure layer on a matrix structure of a pure titanium or titanium alloy implant with a solid structure by using a powder metallurgy method; then forming a titanium dioxide membrane containing calcium and phosphorus on a hole surface of the porous structure layer by a micro-arc oxidation method; and finally, preparing a hydroxyl apatite layer on a hole external surface of the porous structure layer by an electrodeposition method. The invention can realize formation of porous structure layer on the surface of the pure titanium or titanium alloy implant with solid structure, and reduce elastic modulus on the implant surface; meanwhile, the implant is endowed with high biological activity through implantation of a hydroxyapatite layer, and can be used in the field of biological medicine.

Description

technical field [0001] The invention relates to the field of biomedical implants, in particular to the preparation technology of biomedical implants made of pure titanium or titanium alloy, in particular to a method for preparing bioactive ceramic membranes with a titanium surface porous structure layer and low elastic modulus. Background technique [0002] The technology of preparing biomedical implants with titanium (including pure titanium and titanium alloys) as the matrix material has been widely used, but after implanting pure titanium or titanium alloy implants directly into the organism without surface treatment, the implant The combination with the surrounding bone tissue is mainly mechanical chimerism, that is, the implant and the surrounding bone tissue can only be combined at the macroscopic level, and the uneven surface of the implant and the uneven surface of the bone tissue are only in a local area at the microscopic level. Combination, because the elastic mod...

Claims

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Application Information

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IPC IPC(8): C23F17/00A61L27/06A61L27/32A61L27/54A61L27/56
Inventor 张伟杜克勤赵宝红王福会
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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