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Application of small-molecule oligopeptide in preparing product for treating acnes

A technology of small molecules and short peptides, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, cosmetic preparations, etc. It can solve the problems of long treatment period, achieve low toxicity and side effects, and inhibit excessive proliferation , Applicable to a wide range of people

Pending Publication Date: 2020-06-09
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, acne can also be treated by methods such as Chinese medicine decoction and acupuncture, but the course of treatment is longer.

Method used

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  • Application of small-molecule oligopeptide in preparing product for treating acnes
  • Application of small-molecule oligopeptide in preparing product for treating acnes
  • Application of small-molecule oligopeptide in preparing product for treating acnes

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1. Clone formation experiment to determine the growth inhibitory effect of short peptides on human keratinocytes (HACAT), human skin fibroblasts (HSF) and human sebaceous gland cells (SZ95). Among them, human sebaceous gland cells SZ95 were purchased from Suzhou Beina Chuanglian Biotechnology Co., Ltd., human keratinocyte HACAT was purchased from Shanghai Mingjin Biotechnology Co., Ltd., and human fibroblast cell HSF was purchased from Shanghai Aolu Biotechnology Co., Ltd.

[0031] Each group of cells in the logarithmic growth phase was digested with trypsin and pipetted into single cells, diluted to a certain multiple, and then seeded in 6-well plates (1.2×10 6 Each / well) and gently rotate to make the cells evenly dispersed. Add 0μM, 20μM, 100μM and 200μM short peptides to the wells and culture for 2 to 3 weeks, discard the medium, fix the cells, stain them with crystal violet, take pictures and observe and count the number of cell clones.

[0032] The result is figure 1 Sh...

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PUM

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Abstract

The invention discloses application of small-molecule oligopeptide in preparing a product for treating acnes. The small-molecule oligopeptide disclosed by the invention is bFGF (basic fibroblalst growth factor) derived degraded oligopeptide consisting of 8 amino acid residues, and the amino acid sequence of the small-molecule oligopeptide is LQLQAEER. The invention finds that the small-molecule oligopeptide is capable of inhibiting excessive proliferation of sebaceous gland and reducing grease secretion of skin, in addition, is high in stability, small in toxicity and side effect, applicable to massive people, good in percutaneous permeability and capable of continuously acting on treatment parts, therefore, can be applied to antiacne aspects, particularly can be used for treating acnes caused by variation of hormonal levels in the puberty period and the gestation period.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of a small molecule short peptide in the preparation of a product for treating acne. Background technique [0002] Acne is the most common chronic inflammatory disease of the hair follicle sebaceous gland unit in adolescence. Because of its complicated pathogenesis, the pathogenesis is not yet fully understood. At present, patients with excessive skin sebum secretion, abnormal keratinization in the hair follicle, Propionibacterium acnes colonized in the sebaceous gland duct of the hair follicle, and inflammatory factor mediators are considered to be key factors in the development of acne lesions. Due to air pollution, stress caused by the accelerated pace of modern life, and imbalanced levels of sex hormones, the number of people suffering from acne is on the rise. In addition, certain drugs can also cause acne by stimulating the sebaceous glands, especially cor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K9/06A61K47/36A61K8/64A61K8/73A61K8/04A61P17/10A61P17/08A61Q19/00C07K7/06
CPCA61K38/08A61K8/64A61K8/73A61K8/046A61K47/36A61K9/06A61P17/10A61Q19/00A61P17/08C07K7/06
Inventor 陈小佳洪岸苏梓坚
Owner JINAN UNIVERSITY
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