383results about How to "Speed up healing" patented technology

The invention discloses a preparation method of a fibroin and graphene oxide composite bracket material. The preparation method comprises the steps of: performing dissolution, filtration, dialysis and centrifugation on degumming fibrous fibroin in sequence, and then condensing to obtain a silk fibroin aqueous solution; dispersing graphene oxide aqueous solution ultrasonically; filtering in a vacuum manner to remove impurities; mixing the graphene oxide aqueous solution with the silk fibroin solution; mixing uniformly; oscillating at the presence of ultrasonic waves for mutual crosslinking; then centrifuging to obtain a mixed solution; then preparing by adopting a freeze-drying method so as to obtain the porous fibroin and graphene oxide composite bracket material. The high-concentration fibroin and the graphene oxide blended aqueous solution has good mixing property, the obtained composite bracket material is excellent in air permeability and drug-carrying ability, is good in hygroscopic property and waste liquid removal effect, and has wide application foreground.

The invention provides antibacterial hydrocolloid dressing and a preparation method thereof, and belongs to the technical field of medical dressing. The preparation method of the antibacterial hydrocolloid dressing is as follows: firstly, elastomers, tackifying resin, a plasticizer and an antioxidant are added into an internal mixer and mixed to prepare a hot-melt pressure-sensitive adhesive; hydrocolloid particles, polyvinyl alcohol, chitosan derivative and an antibacterial agent are added into the hot-melt pressure-sensitive adhesive and mixed; and the mixture is placed in a press vulcanizer for treatment, a waterproof polyurethane backing is coated with the treated mixture, release paper is covered, and a finished product is prepared after irradiation sterilization. The anti-bacterial hydrocolloid dressing prepared with the method has good antibacterial performance and has no safety risk; and the polyvinyl alcohol ingredient added in the preparation process is crosslinked during irradiation to form physical gel, the integrity of the dressing is effectively maintained, and the corrosion resistance of the dressing is improved.

The invention relates to a bacterial cellulose composite dressing, which is prepared by soaking a composite material composed of bacterial cellulose and non-woven fabrics or woven fabrics in an antibiotics-containing water solution. The bacterial cellulose composite dressing is prepared by following steps: choosing bacterial strains capable of secreting bacterial cellulose to made into a seed mash, then evenly dropwise adding the seed mash on non-woven fabrics or woven fabrics, which have been subjected to a sterilization treatment, adding a small amount of fermentation culture medium for cultivation of 12 to 48 hours, then adding fermentation culture medium, cultivating for 3 to 6d, taking out the fermentation products, and finally subjecting the fermentation products to a purifying treatment so as to obtain the bacterial cellulose composite non-woven fabrics or woven fabrics. The preparation method has the advantages of simple technology, and convenient operation, and is capable of preparing bacterial cellulose wound dressings with various functions according to the needs.

The invention discloses a resilient device of an external fixator in the clinical application of orthopaedics. The resilient device consists of a cylinder, a sliding axle in the cylinder, a flexible apparatus, a sliding nail body and a sliding axle stopper. An anti-spin rivet, a pressure regulation rivet, a pressure regulation nut, a tightening jack bolt, a hollow screw on the cylinder wall and a pressurization hole are arranged in the radial direction on the cylinder wall, wherein, the sliding axle stopper can be provided with a stop jack bolt in the radial direction on the cylinder wall, or a stop nut or a stop fixture block can be arranged on the sliding axle; the cylinder wall can be designed to have equal inner diameters at the upper and lower parts or have the inner diameter of the upper part at the corresponding position of the sliding axle larger than that of the lower part; the flexible device can be made into a flexible capsule or a spring; and the sliding nail body is connected with the cylinder in a sliding manner. The resilient device can match with external fixators of different shapes and structures to form external flexible fixators. When a limb with a fracture suffers axial pressure, the external flexible fixator can have a slight axial movement so that an interaction force can be generated due to the slight movement at the end of fracture so as to stimulate callus to grow at the end of fracture. The resilient device can avoid osteoporosis due to stress shielding of the external fixator, quicken the fracture healing, increase the strength of healed bone and effectively prevent delayed fracture healing or nonunion.

The invention relates to a surface treatment process of a bioactive metallic titanium implant having a multistage micro-pit structure, and the surface treatment process comprises the following steps: pretreatment, sandblasting treatment, acid etching treatment, sputtering treatment and glow discharge treatment; according to the surface treatment process, a multistage micro-pit three-dimensional structure having a bioactive tantalum coating is formed on the surface of the metallic titanium implant, so that the binding strength between the tantalum coating and the metallic titanium implant is very good, the tantalum coating is not easy to shed, shedding of the tantalum coating during or after an implantation process is avoided, the biological activity of the metal titanium implant can be improved, bone deposition of the surface of the metal titanium implant is accelerated, the tissue healing time is shortened, and through the formation of synostosis between the metal titanium implant and a surrounding bone tissue, the effect of improvement of the stability of the metal titanium implant can be achieved.

The invention relates to technology to transform a closed apple orchard through the combination of grafting and tree form reshaping and discloses a grafting and tree form reshaping method of three-branch inarching of the closed apple orchard. Three-branch grafting is carried out at the root of a fruit tree, three scions are grafted at the subcutaneous section and comprise one long scion and two short scions; after the grafted branch buds, the central tree trunk is formed through three-branch inarching, the height of the tree in the current year can reach up to about 2.5m, and the formed central tree trunk can be pruned according to different requirements of the tree form to be reshaped from the next year, thereby realizing improvement of fruit tree breed and fruit tree form in a short period of time.

The invention discloses a preparation method and use of a traditional Chinese medicine asiaticoside carrying core/shell structure nanometer fiber film. The traditional Chinese medicine asiaticoside carrying core/shell structure nanometer fiber film is prepared from a lactic acid/glycollic acid copolymer (PLGA) as a shell and polycaprolactone (PCL) as an inner core through a coaxial electrospinning method. The preparation method has the advantages of use of easily available raw materials, operation easiness, good controllability and large scale industrial production easiness. The traditional Chinese medicine asiaticoside carrying core/shell structure nanometer fiber film can be used for wound dressing and has the advantages of controllable drug loading amount, high drug utilization rate and excellent wound healing promoting effect.

The invention discloses baby skin moistening and protecting cream which comprises the following ingredients in percentage by weight: 2.15085-41.2% of plant extracts, 0.5-8% of at least one of caprylic triglyceride and capric triglyceride, 0.2-3% of sorbitan olivate, 0.5-10% of glycerinum, 0.2-3% of cetearyl olivate, 0.2-3% of glyceryl stearate, 0.1-5% of sorbitol, 0.05-0.3% of xanthan gum, 0.3-0.8% of tocopherol, 0.0001-0.5% of hyaluronic acid, 0.5-3% of erythritol and the balance of water, wherein the plant extracts include avocado butter, olea europaea fruit oil, rice chaff oil, wheat germ oil, oat germ oil, a paeonia suffruticosa root extract and rosmarinus officinalis leaf oil. The baby skin moistening and protecting cream is prepared from various plant extracts and animal extracts and chemicals with small skin irritation, so that the cream has a good effect of moistening and protecting baby skin and has no irritation and toxicity to the baby skin.

The invention discloses a 3D printing method of an individualized porous-layer multi-tooth root implant. The 3D printing method comprises the following steps of step one, scanning an object, and acquiring data; step two, aiming to a scanning region, using an MIMICS software to carry out separation and reconstruction on the data acquired in the step one to obtain a three-dimensional model of a tooth root, a tooth fossa, a corona dentis and a dentition region to be pulled out of the object; step three, utilizing a Magic software to edit the three-dimensional model in the step three, carrying out digital design on a root, an abutment and the corona dentis of the implant, and regulating printing parameters to obtain a model of the implant to be printed; and step four, copying the model of the implant to be printed in the step three into a 3D printer for printing to obtain the individualized porous-layer multi-tooth root implant. The method has the advantages of high manufacturing accuracy, shortening in planting treatment period, reduction in planting cost and improvement in stability of the tooth root implant.

The invention relates to a skin repairing agent prepared by mixing stem cell extract and traditional Chinese medicine extract. A preparation method of the skin repairing agent comprises the followingsteps: (1) culturing umbilical cord mesenchymal stem cells and preparing extract by utilizing technologies including ultrafiltration and the like; (2) extracting total flavonoids of traditional Chinese medicines including rhizoma phragmitis, blue lotus flowers, hibiscus flowers and liquorice roots; (3) mixing the stem cell extract and the traditional Chinese medicine extract. The skin repairing agent provided by the invention can act on parts including scars, stretch marks and the like through methods including spraying, injection and the like; the scars, the stretch marks and the like are treated through promoting tissue revitalization and killing fibroblasts; the skin repairing agent has the advantages of simple method, high efficiency and small side effects; a production technology of the preparation is simple and the cost is low.

The invention discloses application of histatin 1 (Hst1) polypeptide in preparation of composite materials for promoting repair of large-area skin defects. The Hst1 polypeptide is found to have the characteristics of promoting cell adhesion and vascularization and inhibiting inflammatory response. The Hst1 polypeptide can be loaded on a variety of biological materials, and can be prepared into dressing, injection, ointment, powder, hydrogel, membranes, sponges, fiber scaffold materials and the like, which can effectively promote the healing of the large-area skin defects, by being compounded with bioactive composite materials, wherein large-area skin defects include traumas, burns, skin ulcer caused by tumor resection or diabetes, and the like. The Hst1 polypeptide provided by the invention is human-derived polypeptide, and has good biocompatibility and biosafety. When being used for the preparation of the composite materials for promoting the repair of the large-area skin defects, theHst1 polypeptide has an important medical value and a good industrialization prospect.

The invention provides an environment-friendly and simple preparation method for a hyaluronic acid-chitosan microsphere carrying an epidermal growth factor. The hyaluronic acid-chitosan microsphere is prepared via ionic polymerization, centrifugation, purification, and freeze-drying under the protection of a protective agent. The hyaluronic acid-chitosan microsphere carrying the epidermal growth factor can be used for preparing pharmaceutical preparations (including a gel, a film agent, a powder agent, an ointment, and the like) for treating burn and scald wounds. According to the hyaluronic acid-chitosan microsphere carrying the epidermal growth factor and the pharmaceutical preparations of the hyaluronic acid-chitosan microsphere, sustained release of the epidermal growth factor on the burn and scald wounds is realized; wound cell proliferation is promoted; and functions, of protecting burn and scald tissues and promoting wound healing, of sodium hyaluronate and chitosan are developed. The hyaluronic acid-chitosan microsphere can provide a support for wound cell proliferation, and an excellent medicine for treating burn and scald wounds is obtained.

The invention belongs to the technical field of biomedical engineering, particularly belongs to the field of technologies for preparing skin repair materials, and discloses a skin repair material with biological activity and a method for preparing the skin repair material. The skin repair material comprises collagen, DMEM (Dulbecco modified eagle media), keratinocytes and fibroblasts. The skin repair material with the biological activity and the method have the advantages that the skin repair material is low in immunogenicity and excellent in biocompatibility, materials for the skin repair materials come from abundant sources, and obvious effects of promoting wound healing can be realized; the skin repair material is prepared from collagen solution with biological activity by the aid of biological three-dimensional printing technologies and can be prepared according to actual conditions of patients, integral preparation procedures are short in consumed time, the skin repair material can be immediately prepared and used, accordingly, the patients can be truly individually treated, and influence on the performance of products due to misoperation during product transportation or storage can be prevented.

The invention relates to a pressure-adjustable combined-type outer fixing support for clinical orthopedic application. Combining forms of the pressure-adjustable combined-type outer fixing support include a single arm type, a semi-ring type and a ring type, fixing clamping blocks include knitting needle clamping blocks and knitting rod clamping blocks, a pressure-adjustable fixing arm is composed of an adjusting shaft, a sliding fit thread sleeve, an elastic device, a connecting nut, a fastening nut and a fixing rod, the sliding fit thread sleeve is radially provided with a limiting pin, a limiting jack screw, a pressure adjusting pin, an outer ferrule, an inner ferrule, a pressure adjusting nut and a pressure adjusting pin hole, the adjusting shaft is in sliding fit with the sliding fit thread sleeve, the connecting nut is in threaded connection with the sliding fit thread sleeve and the fastening nut, the fastening nut and a pipe clamping pin are in relatively fixed fit, the elastic device is composed of a spring or an elastic capsule, a pressure sensor, a sliding base, a pressure sensor connecting device and a pressure displayer and can be provided with a piezometer or not. The pressure-adjustable combined-type outer fixing support can transmit stress to enable stress to be generated at a fracture end, stress shielding can be avoided, and delayed fracture healing and fracture disunion are prevented.

The invention discloses bone reunion plaster and a preparation method therefor, and belongs to the technical field of traditional Chinese plaster. The bone reunion plaster is prepared from the following raw materials in parts by weight: radix notoginseng, native copper, pangolin scales, eupolyphaga seu steleophaga, sanguis draconis, rhizoma corydalis, lignum sappan, olibanum, myrrha, radix angelicae pubescentis, radix saposhnikoviae, cortex cinnamomi, radix linderae, radix aconiti preparata, radix aconiti kusnezoffii preparata, herba ephedra, radix angelicae, radix clematidis, caulis sinomenii, kadsura pepper stem, herba geranii, dog bone, black-bone chicken, radix angelicae sinensis, radix rehmanniae praeparata, rhizoma ligustici, semen persicae, flos carthami, cortex acanthopanacis, fructus chaenomelis, herba taxilli, radix achyranthis bidentatae, rhizoma drynariae, radix dipsaci, radix paeoniae rubra, radix scrophulariae, radix liquiritiae, rosin, beewax and sesame oil. The bone reunion plaster is capable of reuniting bones, promoting blood circulation to remove blood stasis and eliminating damp to relieve pain, has a relatively good curative effect for various fractures, traumatic injuries and rheumatic numbness, and is high in healing rate.

The invention discloses a preparation method of a chitosan-graphene nano medical dressing for bacterial resistance and wound healing promoting. The preparation method comprises the following steps: S1, chitosan and graphene oxide dispersion liquid obtained after acetic acid is dissolved are uniformly mixed under the ultrasonic effect, an initiator is added to react for 4 h, and thus a graphene-grafted modified chitosan solution is obtained; S2, a reducing agent is added into the graphene-grafted modified chitosan dispersion solution obtained in the step S1 to react at 80-90 DEG C, filtering under reduced pressure is conducted, and after vacuum drying, reduced graphene-chitosan functional master-batches are obtained; and S3, the reduced graphene-chitosan functional master-batches obtained in step S2, auxiliary components and an enhancer are dissolved and mixed, spinning for film forming is conducted to obtain chitosan-graphene nanofiber felt, and liquid-phase enhanced crosslinking is conducted in an acid solution to obtain the chitosan-graphene nano medical dressing for bacterial resistance and wound healing promoting. A special physical healing function can be given to a wound dressing material, and especially the effects in the aspects of physical bacterial resistance and far-infrared radiation to promote wound healing are more obvious.