221results about How to "Protect the wound" patented technology

The subject matter of the invention is a wound care device for treatment of wounds by means of subatmospheric pressure in the wound region, having a wound covering element, a device for generating subatmospheric pressure, which can optionally be placed on the wound covering element, and an absorption body taking up wound exudations.

The invention relates to methods of promoting wound healing and reducing scar formation by administration of corticosteroids, and pharmaceutical compositions comprising corticosteroids.

The invention relates to a hemostatic medicament, in particular to a soluble hemostatic gauze and a preparation method thereof. The soluble hemostatic gauze contains an absorbent gauze, sodium hydroxide, and sodium carboxymethyl cellulose which is generated by, reaction of chloroactic acid in an alcohol solvent; and the weight ratio of the three raw material components is 1: 1.8: 2.35. The methodfor preparing the soluble hemostatic gauze comprises the following steps of water scrubbing, alkalization, etherification, alcohol washing, neutralization, and drying as well as weighing, cutting, and packaging after a prepared semi-finished product is qualified through the inspection. The soluble hemostatic gauze can be applied to exodontia, dermatological surgery, trauma hemostasis, and wound surface protection.

The invention relates to a preparation method of a gel containing stem cell exosomes for repairing skin wounds. The method comprises the following steps: 1) primary extraction and culture of human umbilical cord mesenchymal stem cells: 1.1) primary extraction of human umbilical cord mesenchymal stem cells, 1.2) subculture, and 1.3) collection of the culture supernatant; 2) extraction of human umbilical cord mesenchymal stem cell exosomes: 2.1) primary centrifugation, 2.2) secondary centrifugation, 2.3) removal of organelles by centrifugation, 2.4) coarse extraction of exosomes, and 2.5) finalextraction of exosomes; 3) preparation of a gel material: 3.1) preparation of chitosan, 3.2) configuration of beta-glycerol phosphate (beta-GP), and 3.3) preparation of the gel material; and 4) gel loading of the exosomes. The gel containing stem cell exosomes can promote repair of skin wounds, shorten the healing time of wounds and reduce scar formation.

The invention discloses an ointment for treating burns and a preparation method thereof; the ointment is prepared mainly with rheum officinale, phellodendron, coptis, lithospermum, angelica dahurica, and other Chinese herbal medicines according to a certain weight ratio; and the medicine of the invention has the effect of clearing heat and purging fire, expelling toxin and decontamination, inducing eruption and removing dampness, removing itch and detumescence, removing inflammation and relieving pain, astringency and promoting granulation, anticorrosion and promoting healing, and has the efficacy of high surface activity and strong adsorbability.

A combination of four wound care products include (1) a wound vacuum dressing providing a more sterile cover over the wound to prevent infection, provide a closed system to prevent maceration and soiling from drainage to the surrounding skin and peg insole pad, to introduce and maintain negative pressure, to decrease excessive fluid to the wound(s) and provide an environment to increase granulation and epithelialization; (2) a compression hose for additional support to the lower leg, ankle, and foot, aiding in proper fluid pressure control in the lower extremity and protects against friction of the contact cast against the lower extremity; (3) a removable peg insole foot insert offloading pressure and friction from the wound as well as providing a pressure free pathway to the ankle connection point which prevents obstruction, and (4) a total contact cast with inner padding layer to further off load pressure from the wound(s).

The present invention provides thin-film forming compositions comprising an antiseptic (e.g., povidone iodine, chlorhexidine, or octenidine), a non-aqueous solvent, and a film-forming material dissolved in the non-aqueous solvent, wherein the composition yields a continuous and flexible protective film upon substantial removal of the solvent. The compositions are useful for the treatment and prevention of infections in wounds, ulcers (e.g., decubitus ulcers and stasis ulcers), cuts, or burns, or against infections from bacterial, mycobacterial, viral, fungal, or amoeba causes, as well as for prevention of such infections in appropriate clinical settings (e.g., as liquid bandages or dressings). Additionally, the compositions of this invention are also useful for the treatment of infections and as a disinfectant skin preparation for pre- and / or post-surgical operations.

The present invention relates to Chinese medicine ointment for treating burns and its preparation process. The Chinese medicine ointment for treating burns is prepared with rehmannia root and other ten kinds of Chinese medicinal materials, and through heating to extract in sesame oil, filtering, adding vegetable oil thickener and other steps. The present invention features the added vegetable oil thickener to replace traditional beeswax matrix, and the Chinese medicine ointment for treating burns has high clinical application value, and transport, carrying and use convenience.

The invention relates to a medical article, and mainly relates to a chitosan fluid dressing film for accelerating wound healing for skin burn, trauma, and body surface ulcers, and infection treatment. The chitosan fluid dressing film is prepared by using chitosan as a main raw material; the chitosan is dissolved with acids, and mixed with gelatin fully swelled in water; then glycerin and a silver salt solution are added; under the action of ultrasonic wave, simple substance silver exists in the fluid in a form of nanometer colloidal silver so as to obtain nanometer silver sol. The dressing film of the invention adopts chitosan as a main raw material, has wide-spectrum antibacterial properties, and can be used as dressing for skin modification and skin wound. A lot of -NH2 and -OH are contained in the molecules, which can form cage-shaped molecules with a structure like a net with metal ions through hydrogen bonds, and thus stable coordination is provided for silver ions. Chitosan adsorbed with silver ions has more effective bactericidal effect.

The invention discloses a preparation method of a functional hydrogel medical dressing. The preparation method comprises the following steps: 1. blending a biopolymer material, a chemical synthesized polymer material, a transforming growth factor TGF-beta and distilled water so as to form a physical-crosslinked hydrogel, wherein the biopolymer material consists of carboxymethyl chitosan, chitosan quaternary ammonium salt, gelatin, gellan gum and sodium alginate; and the chemical synthesized polymer material consists of polyvinyl alcohol and polyvinylpyrrolidone; 2. coating and processing the physical-crosslinked hydrogel obtained in the step 1 by virtue of a coating machine; and 3. conducting radiation sterilization on the hydrogel which is coated in the step 2, and implementing radiation crosslinking during the process of radiation sterilization. The method, through physical crosslinking and radiation crosslinking, can form the hydrogen of a dual-network structure; and the hydrogel medical dressing is high in strength and melting-up property, and the dressing is capable of protecting wound surfaces, stopping bleeding, relieving pain, inhibiting bacteria and promoting the growth of epithelial cell.

Disclosed are a medicament for the treatment of burns and sore and ulcer diseases, and a wound plaster made of the same. The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a medicament for the treatment of burns and sore and ulcer diseases. The medicament mainly comprises, by weight, 35 to 65 parts of rosin, 20 to 40 parts of borneol, 30 to 90 parts of beeswax and 500 to 1000 parts of sesame oil. All the components in the invention are in reasonable allocation and complement each other. The utilization of the invention enables effective treatment of burns and scalds and skin ulcer, alleviating pains of patients.

An exterior-applied Chinese medicine for treating burn and local phyma and inflammation is prepared from 10 Chinese-medicinal materials including sanguisorba root, catechu, coptis root, myrrh, etc. Its advantages are high curative effect and no by-effect.

The invention relates to an externally used traditional Chinese medicament for treating skin diseases which is prepared mainly from the following raw materials (by weight portion): cnidium fruit 0. 5-2 parts, roor of sessile stemona 0. 5-2 parts, Cortex Pseudolaricis 0. 5-2 parts, kuh-seng 0. 5-2 parts, sea apron 0. 3-1 part, seaweed 0. 3-1 part, oldenlandia 0. 5-2 parts, rheum officinale 0. 5-2 parts, rheum officinale 0. 2-0. 8 part, Chinese blistering beetle 0. 1-0. 5 part, edible vinegar concentrate 45-55 parts, arisaema tuber 18-25 parts and secretio bufonis 3-5 parts.

The invention relates to a pharmaceutical composition for treating burns and scalds and a preparation method thereof. The pharmaceutical composition for treating burns and scalds is prepared from the following raw materials in parts by weight: 20 parts of wild peony, 20 parts of coptis, 15 parts of giant knotweed, 8 parts of radix angelicae, 7 parts of saffron, 10 parts of gromwell, 10 parts of Mallotus apelta, 15 parts of honeysuckle flower, 25 parts of Baikal skullcap root, 20 parts of angelica, 12 parts of myrrh, 7 parts of dark plum, 5 parts of rhizoma atractylodis, 10 parts of nutgall, 10 parts of hyacinth bletilla, 12 parts of calamine, 3 parts of pseudo-ginseng, 10 parts of calcite, 8 parts of radix sileris, 25 parts of clove, 10 parts of frankincense and 10 parts of sanguisorba. The pharmaceutical composition provided by the invention has the advantages of low cost and obvious curative effect, does not leave scars after treatment, and has wide application prospects.

The invention specifically relates to novel anti-microbial and hemostatic gauze and a preparation method of the novel anti-microbial and hemostatic gauze. The preparation method comprises the following steps: carrying out modified treatment including alkalization, etherification, neutralization, ethanol washing and the like on medical degreasing cotton gauze, thus obtaining sodium carboxymethylcellulose gauze; and carrying out a certain synthetic process (ion exchange) on the sodium carboxymethylcellulose gauze, thus obtaining the sodium carboxymethylcellulose gauze. The prepared carboxymethylcellulose metal salt gauze has the hemostasis function and also has the excellent anti-microbial property, the purposes of stopping bleeding and diminishing inflammation can be rapidly realized without adding of any medicines, meanwhile, the surgical adhesion can be prevented, and finally, the product is decomposed into monosaccharide in the body so as to be absorbed by the human body.

The invention discloses a Chinese medicament for traumatic wound, which belongs to the technical field of Chinese medicaments. The Chinese medicament is characterized by taking 40g of platycladus orientalis, 15g of elephant hide, 40g of rhubarb, 9g of trogopterus dung, 10g of amur corktree bark, 9g of myrrh, 10g of cattail pollen, 15g of rhizoma corydalis, 5g of pyrolusite, 10g of panax notoginseng and 6g of common jujube bark, mixing and crushing the mixture to 200 meshes, then placing the mixture into a pressure cooker, adding 350g of water, then boiling for 5 to 8min under the pressure of 70Pa and taking out; and adding 60g of honey and 6g of borneol when the temperature is reduced to 30 DEG C or so. The traumatized wound is externally applied with the medicament, which can maintain the favorable environment of the wound, is not dry, is favorable for the falling of necrotic tissues, maintains the cleanliness of a wound substrate, reduces infection hazard, protects wound surfaces and promotes the healing.

A burn medicine delivery system for treating burn is prepared from trehalase, hyaluronic acid, and medicinal additive.

The invention provides external-use ointment for treating empyrosis and a preparation method thereof. The external-use ointment is empyrosis humectation ointment prepared from Chinese medicaments and Western medicaments through processing, and comprises the following components in part by weight: 10 to 30 parts of Chinese angelica, 10 to 25 parts of golden thread, 10 to 25 parts of amur corktree bark, 10 to 25 parts of baical skullcap root, 10 to 20 parts of prepared frankincense, 20 to 25 parts of prepared myrrh, 1 to 3 parts of musk, 10 to 20 parts of borneol, 150 to 270 parts of silver sulfadiazine powder, 500 to 1,000 parts of Vaseline and 40 to 80 parts of bees wax. The ointment adopts the Chinese angelica, the frankincense and the myrrh which have the effects of activating blood circulation, relieving pain and promoting tissue regeneration; the golden thread, the amur corktree bark and the baical skullcap root have the effects of clearing away heat and toxic materials and eliminating dampness; the borneol has bitter and cold properties, can clear away heat to be cool when in external use, and has the lasting effect of constringency, tissue regeneration and odynolysis when being compatible with the musk; and the silver sulfadiazine powder has the effects of sterilization and antiphlogosis. The whole medicament has the effects of promoting blood circulation by removing blood stasis, diminishing inflammation and relieving pain, changing rot and promoting tissue, inhibiting exudation and promoting wound healing, and has low incidence rate of scar.

The invention belongs to the field of biological materials and interdiscipline of polymer chemistry and biochemistry and discloses a gelatin / nano silver composite material decorated by microbial transglutaminase and a preparation method and an application thereof. The gelatin / nano silver composite material decorated by microbial transglutaminase is prepared by utilizing a gelatin / nano silver composite material as main material and utilizing the microbial transglutaminase as a modifier, the material has good biocompatibility, non-toxicity and strong antibacterial activity, the mechanical properties and water stability of the material are good, and meanwhile, the material is simple in preparation process, mild in reaction conditions, easy to control and low in production cost, thereby having good application prospect and very extensive usage in biomedical materials and biomedicine field, such as antibacterial and biodegradable skin dressing capable of reducing infection and inflammation and protecting wound, wound healing agent and artificial skin, and the like.

The invention provides an environment-friendly and simple preparation method for a hyaluronic acid-chitosan microsphere carrying an epidermal growth factor. The hyaluronic acid-chitosan microsphere is prepared via ionic polymerization, centrifugation, purification, and freeze-drying under the protection of a protective agent. The hyaluronic acid-chitosan microsphere carrying the epidermal growth factor can be used for preparing pharmaceutical preparations (including a gel, a film agent, a powder agent, an ointment, and the like) for treating burn and scald wounds. According to the hyaluronic acid-chitosan microsphere carrying the epidermal growth factor and the pharmaceutical preparations of the hyaluronic acid-chitosan microsphere, sustained release of the epidermal growth factor on the burn and scald wounds is realized; wound cell proliferation is promoted; and functions, of protecting burn and scald tissues and promoting wound healing, of sodium hyaluronate and chitosan are developed. The hyaluronic acid-chitosan microsphere can provide a support for wound cell proliferation, and an excellent medicine for treating burn and scald wounds is obtained.

The invention discloses a silver-containing composite gel dressing and a preparation method thereof. The silver-containing composite gel dressing comprises chitosan, nano-silver, glycerin and genipin. According to the invention, natural macromolecule material is adopted as raw material to manufacture the composite gel dressing through non-toxic cross-linking technology and glycerin as cross-linking agent; nano-silver is loaded into the gel membrane for fast hemostasis and analgesia; the silver-containing composite gel dressing has excellent biocompatibility, and can be absorbed by human body; the autolysis debridement ensures that the wound adhesion is prevented, so that the secondary damage during dressing changing is prevented to the maximum extent; a beneficial humid environment is provided for wound occlusion; the formation of scar is reduced and eliminated, and the scar inhibiting effect is obvious; the silver-containing composite gel dressing has various efficacy such as hemostasis, analgesia, acceleration for shedding of necrotic tissue, segregation of pathogen, and protection of wound surface, is convenient for wound observation, is easy to manufacture, and is low in cost.

A noninvasive method of ultrasound wound evaluation whereby a health care professional fills a wound with a sterile coupling gel, covers the wound with a non-adhesive couplant sheet, scans the wound with a ultrasound transducer that has been covered with a sterile sheath, thereby producing measurement data about the wound including the diameter, the perimeter and the depth, converting the data into a report package to be utilized by a health care professional to characterize the wound.

The invention relates to a hyaluronic acid bacteriostatic gel, which comprises the following raw materials by weight: 50-60 parts of hyaluronic acid, 30-40 parts of a Chinese medicinal extract, 15-20 parts of DCBA, 3-5 parts of ethanol, 5-8 parts of glycerol, and 10-15 parts of purified water. The Chinese medicinal extract includes the following raw materials: Ampelopsis japonica, radix angelicae dahuricae, white poria, kudzuvine root, trichosanthes root, bighead atractylodes rhizome, dandelion, forsythia, honeysuckle, radix paeoniae rubra, cortex moutan, sophora flavescens and licorice. The hyaluronic acid bacteriostatic gel provided by the invention has bacteriostatic effect on staphylococcus aureus, escherichia coli, and pseudomonas aeruginosa, can be daubed on the skin to form a skin protective film, and is suitable for skin bacteriostasis, bacteriostatic protection postoperative skin wounds and daily skin care.

An artificial skin for repairing the skin defect caused by inflammation, ulcer, burn, etc is composed of surface epidermal cells and fibroblasts. It is prepared through preparing culture liquid, preparing the solution of artificial skin matrix, and culturing artificial skin.

The invention provides a double-bioenzyme modified blending biological material containing gelatin and chitosan and a preparation method and application of the double-bioenzyme modified blending biological material. The blending biological material comprises gelatin and chitosan which are used a blending main body and microbial transglutaminase and tyrosinase which are used as a modifier. The stability of the blending biological material is enhanced, and the mechanical property thereof is improved; furthermore, the material has antimicrobial activity, and has good application prospect and excessively wide application in the fields of biomedical materials and a biomedicine, such as the reduction of infection and inflammatory response, antibiosis, wound protection, a biologically degradable skin dressing, a wound healing agent, artificial skin, and the like; and meanwhile, the material is simple in preparation technology, easy to control, free from side and toxic effects and temperate in preparation condition.

The invention discloses a chitosan cervix uteri anti-microbial membrane and a preparation method thereof. The chitosan cervix uteri anti-microbial membrane has a structure of a circular plate, bulged flangings are formed at the periphery of the circular plate, and a convex body is arranged in the center of the reverse side of the circular plate. The chitosan cervix uteri anti-microbial membrane is prepared from the following raw materials in percentage by mass: 0.5 to 5.0 percent of chitosan iodine, 2.0 to 10.0 percent of polysorbate-20, 0.1 to 2.0 percent of acetic acid, 0.1 to 5.0 percent of hydroxypropyl methyl cellulose, 1.0 to 10.0 percent of gelatin, 1.0 to 10.0 percent of glycerol and the balance of purified water. The chitosan cervix uteri anti-microbial membrane is prepared from novel biological materials synthesized by the chitosan and derivatives thereof by processes of freezing, vacuum drying and the like according to characteristics of human anatomy, pathology, physiology and the like, has a shape of a thin curved surface, and can be in full fit with pathological tissue, absorb wound exudate and eliminate necrotic tissue by being attached to cervix uteri surfaces outside uterine cavities, so that wounds are drained fully; and sterilizing inflammation-diminishing active factors are released in a sustained way at the targeting position to promote wound union effectively. The chitosan cervix uteri anti-microbial membrane is suitable for patients who suffer from gynecological cervical diseases.

The invention discloses a thermo-sensitive filling gel preparation for rhinology, a preparation method of the thermo-sensitive filling gel preparation and an application of the thermo-sensitive filling gel preparation in operation on nasal cavity and paranasal sinuses. The preparation comprises components in percentage by weight as follows: 3%-20% of chitosan, 0.3%-3% of cellulose, 15%-25% of poloxamer and 52%-81.7% of an alkaline buffer solution. The prepared filling gel preparation for the rhinology is thermo-sensitive and has lower viscosity when the preparation does not enter a human body, so that gel can be pushed out easily; the viscosity and adhesive power of the gel are increased due to increase of the temperature when the preparation enters the human body, thus, the gel is not prone to flowing out of the nasal cavity, the time consumed for action with the wound can be effectively prolonged, and the effectiveness of a product is improved. The preparation method is simple, the product has a good filling function in the operation on the nasal cavity and the paranasal sinuses, can effectively prevent nasal mucosa from surface adhesion, control mild bleeding, prevent infection and assist in natural healing, and can be naturally degraded or washed after 7-14 days and is convenient to use.

The invention discloses a pectin hemostatic gauze which is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of pectin, 4-6 parts of gelatin, 1-2 parts of poloxamer 188, 3-5 parts of sodium alga acid, 1-2 parts of wheat germ oil, 1-2 parts of soybean oil, 0.1-0.2 part of polysorbate-80, 0.05-0.1 part of propylgallate, 1-2 parts of lactose, 1-2 parts of xylitol, 2-4 parts of sodium carboxymethylcellulose, 1-2 parts of auxiliary materials and 200-250 parts of water. A soluble hemostatic gauze is prepared by taking natural pectin as a main ingredient, has a good hemostatic function and can achieve the effects of resisting bacteria, diminishing inflammation and protecting the wound; and meanwhile, the pectin hemostatic gauze is rich in raw materials, simple in preparation process, low in cost, safe, environment-friendly and high in biocompatibility, is easily absorbed by a human body and does not have any toxic or side effect.

The invention discloses a chitosan wound dressing and preparation and application thereof. The chitosan wound dressing is prepared from the raw materials of N-glycosylated chitosan, aloe extract, polyvinyl alcohol aqueous solution with mass concentration of 10%, polyethylene glycol, glycerol, olive oil, povindone-iodine, hydrogen peroxide with mass concentration of 30%, lactic acid, menthol, ethanol aqueous solution with volume concentration of 95%, and 5 mg / mL normal saline. The applying type fluid wound dressing is applicable to protection and the like of skin abrasions and cuts, skin chaps, minor burns and scalds and sutured surgical wounds.

The invention provides a portable wound surface protection and treatment system having the sealed negative-pressure drainage function and the washing function. The portable wound surface protection and treatment system comprises a wound surface sealing device and further comprises a liquid storage bottle and a negative-pressure drainage washing instrument which are integrated. One end of a drainage pipe is communicated with the top of the liquid storage bottle, and the other end of the drainage pipe is arranged in the wound surface sealing device. One end of a washing pipe is communicated with a liquid sucking opening formed in the side portion of the bottom of the liquid storage bottle, and the other end of the washing pipe is connected with a peristaltic pump of the negative-pressure drainage washing instrument and then arranged in the wound surface sealing device. The liquid storage bottle is connected with a negative-pressure pump of the negative-pressure drainage washing instrument through an air exhaust opening formed in the top of the liquid storage bottle. By the adoption of the portable wound surface protection and treatment system, when a wounded person is treated in the wild under simple and crude conditions, sealed negative-pressure drainage and instillation washing can be conducted on an open wound surface at the same time, so that wound surface protection, infection prevention, wound healing promotion, the reduction of the difficulty in evacuation of the wounded person is reduced, and relieving of the intensity of nursing of the wounded person are achieved.