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Silver-containing composite gel dressing and preparation method thereof

A compound gel and formula technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of weak bacterial isolation and inconvenient fixation, and achieve the functions of promoting wound healing, preventing bacterial infection, and broad antibacterial spectrum Effect

Active Publication Date: 2014-01-01
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the dressing is in contact with the tissue, repeated hydration can occur, and the water in the tissue is absorbed into the dressing. With the increase of water absorption, the dressing gradually swells until it reaches equilibrium. It has strong water absorption, good heat preservation effect, and is translucent for observation. Wounds, but non-adhesive, not easy to fix and not strong for bacteria isolation

Method used

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preparation example Construction

[0018] Its preparation method comprises the following steps:

[0019] a) weighing each raw material according to the formula ratio;

[0020] B) the chitosan of described weight part is dispersed in the deionized water of described weight part, after stirring, add the nano-silver and glycerin of described weight part, make mixed liquor;

[0021] c) Take the mixed solution, add the weight part of genipin to carry out cross-linking, and react at 35-40°C for 12-36h to obtain the product.

[0022] The present invention has softness similar to that of human skin, and can maintain a certain shape and strength when wet; can maintain a moist environment on the wound surface, has better ability to absorb wound secretions, and has certain air permeability; Non-toxic, no harmful reaction and stimulation to the human body, and can prevent bacteria from entering the wound to prevent secondary infection, avoid wound contact with particles and toxic pollutants; it has hemostatic and pain-rel...

Embodiment 1

[0025] A silver-containing composite gel dressing comprises the following components by weight: 25,000 parts of chitosan, 100 parts of nano-silver, 50 parts of glycerin, 30 parts of genipin, and 5,000 parts of deionized water.

[0026] Its preparation method comprises the following steps:

[0027] a) weighing each raw material according to the formula ratio;

[0028] B) the chitosan of described weight part is dispersed in the deionized water of described weight part, after stirring, add the nano-silver and glycerin of described weight part, make mixed liquor;

[0029] c) Take the mixed solution, add the weight part of genipin to carry out cross-linking, and react at 35°C for 12 hours to obtain the product.

Embodiment 2

[0031] A silver-containing composite gel dressing comprises the following components by weight: 28,000 parts of chitosan, 180 parts of nano-silver, 80 parts of glycerin, 45 parts of genipin, and 15,000 parts of deionized water.

[0032] Its preparation method comprises the following steps:

[0033] a) weighing each raw material according to the formula ratio;

[0034] B) the chitosan of described weight part is dispersed in the deionized water of described weight part, after stirring, add the nano-silver and glycerin of described weight part, make mixed solution;

[0035] c) Take the mixed liquid, add the weight part of genipin to carry out cross-linking, and react at 37°C for 18 hours to obtain it.

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PUM

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Abstract

The invention discloses a silver-containing composite gel dressing and a preparation method thereof. The silver-containing composite gel dressing comprises chitosan, nano-silver, glycerin and genipin. According to the invention, natural macromolecule material is adopted as raw material to manufacture the composite gel dressing through non-toxic cross-linking technology and glycerin as cross-linking agent; nano-silver is loaded into the gel membrane for fast hemostasis and analgesia; the silver-containing composite gel dressing has excellent biocompatibility, and can be absorbed by human body; the autolysis debridement ensures that the wound adhesion is prevented, so that the secondary damage during dressing changing is prevented to the maximum extent; a beneficial humid environment is provided for wound occlusion; the formation of scar is reduced and eliminated, and the scar inhibiting effect is obvious; the silver-containing composite gel dressing has various efficacy such as hemostasis, analgesia, acceleration for shedding of necrotic tissue, segregation of pathogen, and protection of wound surface, is convenient for wound observation, is easy to manufacture, and is low in cost.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a silver-containing composite gel dressing and a preparation method thereof. Background technique [0002] The skin is an important organ of the human body. It plays a role in controlling body temperature, preventing infection and loss of body fluids, immunity and sensing. Extensive damage to the skin may result from trauma, abrasions, skin ulcers, and burns. Damage to the skin is prone to bacterial infection, loss of body fluids and various complications. Wound dressings are usually used to protect the wound, prevent infection and dehydration of the wound, maintain a moist environment conducive to treatment at the wound, improve the therapeutic effect, and promote wound healing. [0003] Traditional gauze dressing Gauze is usually made of cotton and linen. It has good absorption, is easy to make, and is low in cost. However, it cannot keep the wou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/44
Inventor 刘尧朱天钢李延浩
Owner HENAN HUIBO MEDICAL CO LTD
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