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Preparation method of functional hydrogel medical dressing

A manufacturing method and technology for hydrogels, which are applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of fragility, increased toxicity of the gel system, and low mechanical strength of hydrogels, avoiding biological toxicity and achieving excellent dissolution. sex, and the effect of promoting the growth of epithelial cells

Inactive Publication Date: 2016-02-17
上海威尔医疗保健厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogels currently used are basically made by one of chemical cross-linking, radiation cross-linking and physical cross-linking. The hydrogel synthesized by a single method contains a large amount of water to increase the molecular chain length between cross-linking points. Factors such as too wide distribution lead to low mechanical strength of the hydrogel and are very brittle, and chemical cross-linking inevitably introduces cross-linking agents, initiators, and organic solvents during the synthesis process, which will increase the toxicity of the gel system

Method used

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  • Preparation method of functional hydrogel medical dressing
  • Preparation method of functional hydrogel medical dressing
  • Preparation method of functional hydrogel medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] A 30Kg functional hydrogel medical dressing is composed of 1800g of biopolymer material, 3000g of chemically synthesized polymer material, 1.125g of transforming growth factor TGF-β and 25198.875g of distilled water, wherein the biopolymer material is composed of carboxymethyl Chitosan 450g, chitosan quaternary ammonium salt 450g, gelatin 450g, gellan gum 150g, sodium alginate 300g, chemically synthesized polymer material is composed of polyvinyl alcohol 1500g and polyvinylpyrrolidone 1500g.

[0064] The functional hydrogel medical dressing of the present embodiment 1 is made according to the following steps:

[0065] Step 1. Measure the components of Substance A, Substance B and Substance C according to Table 1 below, and blend them using the following steps to form a physically crosslinked hydrogel:

[0066]

[0067] Table 1

[0068] a. Put each component material of substance A in the above table 1 into a vacuum compounder and stir for 30 minutes, make the materi...

Embodiment 2

[0085] A 30Kg functional hydrogel medical dressing in the proportion of Example 2 is composed of 2100g of biopolymer material, 3900g of chemically synthesized polymer material, 1.125g of transforming growth factor TGF-β and 23998.875g of distilled water, wherein The molecular material is composed of 450g of carboxymethyl chitosan, 450g of chitosan quaternary ammonium salt, 450g of gelatin, 300g of gellan gum, and 450g of sodium alginate. The chemically synthesized polymer material is composed of 2400g of polyvinyl alcohol and 1500g of polyvinylpyrrolidone composition.

[0086] The functional hydrogel medical dressing of the present embodiment 2 is made according to the following steps:

[0087] Step 1. Measure each component of material A, material B and material C according to the following table 2, and use the following steps to blend them to form a physically cross-linked hydrogel:

[0088]

[0089] Table 2

[0090] a. Put each component material of Substance A in Tabl...

Embodiment 3

[0107] A 30Kg functional hydrogel medical dressing in the proportion of Example 3 is composed of 3090g of biopolymer material, 6300g of chemically synthesized polymer material, 13.5g of transforming growth factor TGF-β and 20596.5g of distilled water. The molecular material is composed of carboxymethyl chitosan 90g, chitosan quaternary ammonium salt 1410g, gelatin 60g, gellan gum 1440g, sodium alginate 90g, chemically synthesized polymer material is composed of polyvinyl alcohol 900g and polyvinylpyrrolidone 5400g composition.

[0108] The functional hydrogel medical dressing of present embodiment 3 is made according to the following steps:

[0109] Step 1. Measure each component of material A, material B and material C according to the following table 3, and use the following steps to blend them to form a physically cross-linked hydrogel:

[0110]

[0111] table 3

[0112] a. Put each component material of Substance A in the above Table 3 into a vacuum mixer and stir for...

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Abstract

The invention discloses a preparation method of a functional hydrogel medical dressing. The preparation method comprises the following steps: 1. blending a biopolymer material, a chemical synthesized polymer material, a transforming growth factor TGF-beta and distilled water so as to form a physical-crosslinked hydrogel, wherein the biopolymer material consists of carboxymethyl chitosan, chitosan quaternary ammonium salt, gelatin, gellan gum and sodium alginate; and the chemical synthesized polymer material consists of polyvinyl alcohol and polyvinylpyrrolidone; 2. coating and processing the physical-crosslinked hydrogel obtained in the step 1 by virtue of a coating machine; and 3. conducting radiation sterilization on the hydrogel which is coated in the step 2, and implementing radiation crosslinking during the process of radiation sterilization. The method, through physical crosslinking and radiation crosslinking, can form the hydrogen of a dual-network structure; and the hydrogel medical dressing is high in strength and melting-up property, and the dressing is capable of protecting wound surfaces, stopping bleeding, relieving pain, inhibiting bacteria and promoting the growth of epithelial cell.

Description

technical field [0001] The invention relates to a medical dressing for treating sores, wounds or other injuries, in particular to a method for manufacturing a functional hydrogel medical dressing. Background technique [0002] Medical dressings are a class of important medical materials used to cover sores, wounds or other injuries. They can replace damaged skin to act as a temporary barrier, avoid or control wound infection, and provide an environment conducive to wound healing. New medical dressings combine advanced knowledge of biology, physiology, surgery, nursing and nutrition, and apply various actual needs of patients for dressings, such as physical and clinical, to the material selection and shape design of dressings. The new dressings are divided into films, alginates, foams, hydrocolloids, medicinal dressings and hydrogels. [0003] Film dressings are transparent, easy to observe the wound, can closely adhere to the wound surface, effectively retain the wound exud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44A61L15/42
Inventor 唐耀明
Owner 上海威尔医疗保健厂
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