The invention provides a gold nano-star @
quantum dot composite
cell probe with photothermal and
fluorescence enhancement dual-functions, which sequentially comprises a gold nano-star, a silica layer,
quantum dots and a silica nano-shell layer from inside to outside. The
cell probe is prepared by using a chemical layer-by-layer growth method implemented through the following steps of: firstly, preparing a gold nano-star by using a
seed crystal growth method;
coating a silica layer on the outside of the gold nano-star by means of
hydrolysis so as to form a silica sphere coated with the gold nano-star; then, linking
quantum dots on the surface of the silica sphere through a crosslinking reaction so as to form a silica sphere
composite material internally coated with the gold nano-star and externally linked with the quantum dots; and finally,
coating a silica nano-shell layer on the surface of the
composite material. Compared with traditional probes, the probe integrates the functions of photothermal treatment and
fluorescence labeling; the
fluorescence intensity of the quantum dots is enhanced, and the biological toxicities of the gold nano-star and the quantum dots are effectively avoided; and in addition, the
cell probe has
extremely good biological compatibility.