Method for preparing hydrogel through using imine oligomer as cross-linking agent
A technology of cross-linking agent and polyimine, which is applied in the field of cross-linked polymers to prepare hydrogels, which can solve problems such as local temperature rise, tissue or cell damage, etc.
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Embodiment 1
[0030] (1) Prepare dialdehyde solution
[0031] Dissolve 0.103 g of terephthalaldehyde in 1 mL of absolute ethanol at room temperature, with a mass fraction of aldehydes of 10.4%, and mix well at room temperature for later use;
[0032] (2) Preparation of oligoimine crosslinking agent
[0033] Take 100 μL of spermidine, drop it into terephthalaldehyde ethanol solution, mix until clear, the molar ratio of aldehyde groups in terephthalaldehyde to amino groups in spermidine is 1.2:1, react at room temperature for 30 seconds, An oligomeric imine crosslinking agent was prepared.
[0034] (3) Oligoimine cross-linked hydrogel
[0035] The prepared oligoimine cross-linking agent was added dropwise to 1 mL of acetic acid aqueous solution of chitosan with a mass fraction of 2% (the volume fraction of acetic acid in the acetic acid aqueous solution was 1%), and the cross-linking agent and the polymer passed through The imine bond is bonded to form a hydrogel, and the reaction time is ...
Embodiment 2
[0037] (1) Prepare dialdehyde solution
[0038] Dissolve 0.103 g of terephthalaldehyde in 1 mL of absolute ethanol at room temperature, with a mass fraction of aldehydes of 10.4%, and mix well at room temperature for later use;
[0039] (2) Preparation of oligoimine crosslinking agent
[0040] Take 100 μL of spermidine, drop it into terephthalaldehyde ethanol solution, mix until clear, the molar ratio of aldehyde groups in terephthalaldehyde to amino groups in spermidine is 1.2:1, react at room temperature for 30 seconds, An oligomeric imine crosslinking agent was prepared.
[0041] (3) Oligoimine cross-linked hydrogel
[0042]The prepared oligoimine cross-linking agent was added dropwise to 1 mL of chitosan lithium hydroxide / potassium hydroxide / urea solution with a mass fraction of 2% (lithium hydroxide, potassium hydroxide in 100 g alkali solution , urea, and water are 4.5g: 7g: 8g: 80.5g respectively), the cross-linking agent and the macromolecule are bonded by imine bon...
Embodiment 3
[0044] (1) Prepare dialdehyde solution
[0045] Dissolve 0.128 g of terephthalaldehyde in 1 mL of absolute ethanol at room temperature, the mass fraction of aldehydes is 12.92%, and mix well at room temperature for later use;
[0046] (2) Preparation of oligoimine crosslinking agent
[0047] Take 100 μL of spermidine, drop it into terephthalaldehyde ethanol solution, mix until clear, the molar ratio of aldehyde groups in terephthalaldehyde to amino groups in spermidine is 1.5:1, react at room temperature for 30 seconds, An oligomeric imine crosslinking agent was prepared.
[0048] (3) Oligoimine cross-linked hydrogel
[0049] The prepared oligoimine cross-linking agent was added dropwise to 1 mL of acetic acid aqueous solution of chitosan with a mass fraction of 2% (the volume fraction of acetic acid in the acetic acid aqueous solution was 1%), and the cross-linking agent and the polymer passed through The imine bond is bonded to form a hydrogel, and the reaction time is 30...
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