267 results about "Single probe" patented technology

A biopsy device and method are provided for obtaining a tissue sample, such as a breast tissue biopsy sample. The biopsy device includes a disposable probe assembly with an outer cannula having a distal piercing tip, a cutter lumen, and a cutter tube that rotates and translates past a side aperture in the outer cannula to sever a tissue sample. The biopsy device also includes a reusable hand piece with an integral motor and power source to make a convenient, untethered control for use with ultrasonic imaging. The reusable hand piece incorporates a probe oscillation mode to assist when inserting the distal piercing tip into tissue. A straw stacking assembly is automatically positioned by the reusable hand piece to retract multiple samples with a single probe insertion as well as giving a visual indication to the surgeon of the number of samples that have been taken.

The present invention relates to devices and methods for measuring tissue temperature during thermal treatment of a body. More particularly, the present invention relates to a thermal probe comprising a plurality of thermal sensors operable to measure tissue temperatures during thermal treatments such as cryosurgery. Embodiments of the invention enable simultaneous measurements, using a single probe, of temperatures at a plurality of positions within body tissues. A preferred embodiment enables movement of sensors with respect to tissues while the probe is immobilized by being embedded in frozen tissue.

Techniques for ultrahigh density writing on an erasable magnetic medium include using a micromachined mechanism having two probes for writing to the medium. Use of the two probe embodiment eliminates the need to change the magnetic orientation of the probe. In another embodiment, a single probe is provided which is heated to the vicinity of its Curie temperature to enable the magnetic orientation of the probe to be switched. The probe may be heated to its Curie temperature through the use of a heating element or a focused laser. In another embodiment of the present invention, either the magnetic orientation of the probe or the magnetic orientation of the medium may be switched through the combination of a static magnetic field, a radio frequency magnetic field and, under certain circumstances, the magnetic field of the probe. In all cases, the writing techniques enable information to be written to a magnetic medium in a manner which enables the information to be erased and the medium rewritten.

A probe card of a wafer test system includes one or more programmable ICs, such as FPGAs, to provide routing from individual test signal channels to one of multiple probes. The programmable ICs can be placed on a base PCB of the probe card, or on a daughtercard attached to the probe card. With programmability, the PCB can be used to switch limited test system channels away from unused probes. Programmability further enables a single probe card to more effectively test devices having the same pad array, but having different pin-outs for different device options. Reprogrammability also allows test engineers to re-program as they are debugging a test program. Because the programmable IC typically includes buffers that introduce an unknown delay, in one embodiment measurement of the delay is accomplished by first programming the programmable IC to provide a loop back path to the test system so that buffer delay can be measured, and then reprogramming the programmable IC now with a known delay to connect to a device being tested.

A sample having a plurality of probe molecules is illuminated with at least one beam of excitation light that is linearly polarized along a first axis, thereby effecting fluorescence emission in a plurality of spectral bands. The intensity of a first component of fluorescence emission that is polarized along the first axis, as well as the intensity of a second component of fluorescence emission that is polarized along an orthogonal second axis, is measured for each of said plurality of spectral bands. These measurements are represented as a measurement vector M. Since each probe emits some limited amount of light in the characteristic band of another probe, this results in cross-talk between probes. The measurement vector is therefore corrected using an instrument response matrix A, which is generated by measuring the flux output of control samples which each have only a single probe species. A flux vector S is calculated according to S=A.sup.-1M, and the fluorescence polarization FP is calculated from the S values.

A biopsy device and method are provided for obtaining a tissue sample, such as a breast tissue biopsy sample. The biopsy device includes a disposable probe assembly with an outer cannula having a distal piercing tip, a cutter lumen, and a cutter tube that rotates and translates past a side aperture in the outer cannula to sever a tissue sample. The biopsy device also includes a reusable hand piece with an integral motor and power source to make a convenient, untethered control for use with ultrasonic imaging. The reusable hand piece incorporates a probe oscillation mode to assist when inserting the distal piercing tip into tissue. A straw stacking assembly is automatically positioned by the reusable hand piece to retract multiple samples with a single probe insertion as well as giving a visual indication to the surgeon of the number of samples that have been taken.

A method for determining respiration rate in a patient can include various parts. The respiration rate can be determined by measuring the heart's S2 split. The S2 split can be identified by observing the timing of the heart sounds. Other respiration related information, such as respiration phase and the occurrence of apnea, can be identified as well. A respiration monitor of this type may be useful for monitoring sub-acute patients, and outpatients. A sensor for the respiration monitor and an electrode for an ECG monitor may be combined into a single probe.

A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow.

Multiple probes / primers expand the capability of single-probe real-time PCR. Multiplex real-time PCR uses multiple probe-based assays, in which each assay have a specific probe labeled with a unique fluorescent dye, resulting in different observed colors for each assay. Real-time PCR instruments can discriminate between the fluorescence generated from different dyes. Different probes / primers are labeled with different dyes that each have unique emission spectra. By combining the encoded microbeads and real-time PCR amplification, it is possible to increase the multiplexity of PCR experiments to a very large number, such as 128 with 7 digit or 4,096 with 12-digit barcode. Oligonucleotide probes / primers labeled with encoded microbeads offer the ability to monitor the reaction kinetics of each probe which is tagged with barcoded beads.

The new type compound probe is used to measure the parameter of plasma in high accuracy, real time and with certain space resolution, which belongs to the technical area of plasma diagnosis. The character is that installing Langmuir single probe and the difference emission probe into the same probe tube forms the compound probe. Measuring the parameter of plasma in high accuracy and real time is realized by combining following circuits and software. These circuits and software are: Langmuir single probe scanning circuit, the automatic follow circuit of the space electric potential for the difference emission probe, the pulse generating circuit of square wave, computer interface circuit as well as software for automatic collecting and analyzing data.

The present invention relates to an automatic chemistry analyzer comprising a reaction disk assembly (1), a sample and reagent disk assembly (2), a probe assembly (3) and a stirring assembly (4). A single probe (5) is used to dispense both the reagent and the sample into the reaction vessels. A pre-heating device disposed in the mechanical arm (6) for supporting the probe (5) pre-heats the reagent sucked into the probe to an appropriate temperature. The reaction vessels are disposable and may be replaced manually. The automatic chemistry analyzer may run single-reagent tests or double-reagent tests. According to the automatic chemistry analyzer of the present invention, the interval between injecting the first reagent of a test and injecting the sample of the same test may be 5.5 operation periods so that the first reagent in the reaction vessel may be maintained at or near an appropriate reaction temperature (37° C.). In a process of running a double-reagent test, the incubation time between injecting the sample and injecting the second reagent is set freely by the operator according to the requirements of the test. The automatic chemistry analyzer and the analyzing method according to the present invention may improve the test correctness.

The invention belongs to the field of medical signal processing, and provides a detection method of vascular elasticity and blood pressure based on a single probe photoplethysmography pulse wave. According to the technical scheme, through the adoption of the detection method, quantization of the vascular elasticity and estimation of the blood pressure are achieved on the condition that a photoplethysmography pulse wave is collected merely through a single probe. The detection method comprises the first step of collecting the pulse wave and the blood pressure based on a pulse wave collecting system and a cuff sphygmomanometer; the second step of extracting features related to the vascular elasticity and the blood pressure; the third step of building a blood pressure predicting linear regression equation through the adoption of a stepwise regression method according to a relevant feature quantity; the fourth step of training a BP neural network according to the relevant feature quantity, and measuring the elasticity of an artery blood vessel and a blood pressure value through the trained neural network. The detection method of the vascular elasticity and blood pressure based on the single probe photoplethysmography pulse wave has the advantages that the algorithm performance is good, the quantization of the elasticity of the artery blood vessel wall of the human body can be achieved through the photoplethysmography pulse wave collected by the single probe, and the blood pressure value can be accurately predicted.

The invention relates to a method for measuring a mean visco-elasticity value for a soft material. Said method using a single probe carrying at least one transducer comprises the steps of:a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from said constraint zone into the tissue,b1) measuring, with said transducer, the transient tissue displacements in at least one first measurement zone in the tissue, said first measurement zone being located away from said constraint zone,c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from said measured transient tissue displacements of the tissue in the first measurement zone.

A load balancer sends a probe packet to a first server in a list of servers. Each server in the list sends the probe successively down the list of servers and acknowledges the probe if the server is healthy. The final server in the list sends a signal to the load balancer to indicate that the chain of server probing has completed successfully. In this manner, the load balancer (or other device performing the checking) only needs to send a single probe rather than probe each server in the list separately. Embodiments include serial and recursive acknowledgments from the servers, sending a beacon message upon failure, and other features.

A single probe system is utilized to quickly obtain uncontaminated formation fluid samples. The single probe includes an outer guard tube and an inner sampling tube which is slightly recessed relative to the outer tube such that the pressure at the front face of the probe is substantially uniform. Each tube is coupled to its own pump which controls the flow rate of the fluid moving through that tube. Knowing the size of the sampling tube relative to the size of the outer probe tube, and optionally based on relative viscosities of formation fluids and filtrates, the pumps are caused to generate a particular flow rate ratio through the tubes such that an appropriate pressure is maintained at the front face of the probe and such that the fluid flowing through the sampling tube is substantially uncontaminated.

A compensated flow measuring system for measuring a multi-phase fluid flow in a well. An impeller intercepts a downhole multi-phase flow. Capacitance and conductivity sensors are mounted in close proximity to the impeller and provide a measure of electrical admittance of the fluid. In one embodiment, the capacitance and conductivity sensors are mounted in at least one single probe mounted near the impeller. An electronics system contains a phase detector for separating the capacitive and conductive signals and providing a signal related to a compensated multiphase flow rate.

The invention discloses a blade optical rapid measurement method based on a double-probe four-axis measurement system. According to the method, two non-contact laser displacement sensors are combined on one same four-axis measurement system, in a respective work scope, measurement of a certain special scope of a blade is respectively realized, the measurement results of the two sensors are fused, complete angle three-dimensional point cloud data of an object is acquired, and precise measurement of the blade is lastly realized. The method is advantaged in that a mode of combination of the two non-contact laser measurement probes is employed to carry out three-dimensional measurement of the object, a problem of incomplete data caused by utilizing a single probe for measurement in the prior art is effectively solved, a problem of point cloud data loss of a certain point angle caused by fixed measurement orientation is solved, and measurement precision is improved.

The invention discloses a fluorescent probe for detecting hydrogen sulfide (H2S) and hypochlorous acid (HClO) in cell lysosomes simultaneously or respectively as well as a preparation method and application of the fluorescent probe, and belongs to the field of analytical chemistry. The molecular formula of the probe disclosed by the invention is C44H43N9O7, and the structural formula of the probe is shown in the formula (I). According to the invention, multiple target molecules (H2S, HClO and H2S / HClO) are simultaneously or respectively detected by a single probe, and different signal responses can be produced for different target molecules. The probe of the invention has the specificity of selecting H2S and HClO, and strong capacity of resisting interference of other molecules. The fluorescent probe disclosed by the invention can be applied to detection of H2S and HClO in a water environment and a cellular level, is a simple, fast and sensitive molecular specificity detection reagent of H2S and HClO and has broad application prospects in the field of biomolecule detection.

The present invention relates to devices and methods for measuring tissue temperature during thermal treatment of a body. More particularly, the present invention relates to a thermal probe comprising a plurality of thermal sensors operable to measure tissue temperatures during thermal treatments such as cryosurgery. Embodiments of the invention enable simultaneous measurements, using a single probe, of temperatures at a plurality of positions within body tissues. A preferred embodiment enables movement of sensors with respect to tissues while the probe is immobilized by being embedded in frozen tissue.

A probe type acoustic transit-time flow sensor has paired transducers arranged to generate quasi-helical acoustic beams making a plurality of reflective contacts with a pipe's interior wall. The transducers in each pair are spaced apart along the flow axis so that transit-time measurements can be used both to measure the internal diameter of the pipe and to determine a flow rate. These measurements are combined to yield a volumetric flow rate. Various numbers of pairs of transducers can be put on a single probe or on multiple probes and used to provide a more accurate representation of a flow profile and therefore a more accurate volumetric flow determination.

The present disclosure relates to a method and an apparatus for scanning an object. Two virtual, orthogonal axes are positioned on a surface of the object. A scanning path of a moving probe is controlled as a function of the two virtual, orthogonal axes. The scanning path can include a plurality of probe positions determined according to a desired coverage of the object. A single probe can be used or, optionally, a pair of probes or an array of probes can be used, optionally mounting the probes on a multi-axis movable support. Optionally, a computer-aided design representing the object can be used to parameterize the object. The method and apparatus can be used to create an image of the object for non-destructive testing.

This invention provides compositions and methods for HCV typing, e.g., genotyping and / or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV genotypes (for example, selected from genotypes 1, 2, 3, 4, 5 or 6), or assign an HCV isolate to one of at least six subtypes (for example, selected from subtypes 1a / b / c, 2a / c, 2b, 3a, 4a, 5a or 6a), where the methods of the invention use only a single typing probe to make the HCV type assignment.

An apparatus for estimating a property of an earth formation includes a carrier configured to be conveyed through a borehole penetrating the formation and a single probe configured to be extended from the carrier and to seal with a wall of the borehole. The apparatus further includes a fluid analysis sensor disposed at the carrier and configured to sense a property of a formation fluid sample extracted from the formation by the probe. A coring device is disposed at the carrier and configured to extend into the probe, to drill into the wall of the borehole, and to extract a core sample. A core sample analysis sensor is disposed at the carrier and configured to sense a property of the core sample. A processor is configured to receive data from the fluid analysis sensor and the core sample analysis sensor and to estimate the property using the data.

The invention discloses a Langmuir multi-probe control circuit used for plasma diagnosis and belongs to the technical field of plasma diagnosis. The control circuit is located outside a plasma device and comprises three Langmuir single-probes, an alternating-current sawtooth wave supply voltage generation device, a direct-current supply voltage generation device, a double-pole-double-throw switch, a reversing switch, a first double-pole-three-throw switch, a second double-pole-three-throw switch, a first single-pole-single-throw switch, a second single-pole-single-throw switch and a transform resistor. Selection of the Langmuir single-probes, a double-probe, and a three-probe in different diagnosis circuits is carried out through switching-over of the switches in control circuits, and a cleaning circuit is provided for cleaning of the probes. According to the Langmuir multi-probe control circuit used for the plasma diagnosis, similarities of three probe diagnosis methods on an experimental instrument are used, experimental cost can be saved, different methods can be used by switching-over of the control circuits due to the fact that difference of the three probe diagnosis methods are combined, convenience and high efficiency are achieved, experimental period is greatly shortened, and experimental results are enabled to be accurate due to the fact that the probes can be cleaned during experiment.

Disclosed is a method for detecting CYP450 enzymatic activity by means of micro-liver tissue incubation in vitro, which is characterized in that: a liver trace puncturing method used in clinic takes micro-liver tissues of 0.1 to 0.2g, or kills a mouse to take out the liver in an animal experiment, and builds a micro-liver tissue in vitro incubation system, then uses a one-probe medicine to perform the liquid phase chromatography tandem mass spectrometry for detecting probe substrates and concentration of corresponding metabolites, and obtains the activity of P450 enzyme according to metabolite ratios thereof. The method has the advantages of: 1. micro scale: only micro-liver tissues of 0.1 to 0.2g are needed for detecting cytochrome P450enzyme activity, and can be used for animal experiment and checking clinic micro-liver tissue liver drug enzyme activity; 2. time saving and convenience: costly ultracentrifugation equipment used in the conventional method is saved, costs and time for detection are greatly saved, and liver enzyme metabolic condition simulation is better; and 3. establishing indexes for evaluating the enzyme metabolic activity: metabolite ratios.

The invention comprises methods and compositions for enriching for a target nucleic acid with a single primer extension and low-bias limited amplification.

The invention discloses a cylindrical probe used for plume measurement of a magnetic plasma thrustor. The cylindrical probe includes single probe modules, a four-hole ceramic tube and a Langmuir probe protection tube module. The single probe module includes a thick single-hole ceramic tube, a thin single-hole ceramic tube and a tungsten filament. One end of the thin single-hole ceramic tube and one end of the thick single-hole ceramic tube are flush to each other and are fixed to each other. The tungsten filament is inserted to the thin single-hole ceramic tube. An end face of the four-hole ceramic tube is provided with four through holes. Three identical single probe modules are inserted into three of the four through holes. The Langmuir probe protection tube module includes a protection tube, a flat gasket, a fastening screw, a nut and a spring gasket. The four-hole ceramic tube with the fixed single probe modules is inserted from the protection tube and gets fixed. The cylindrical probe provided by the invention has advantages that the four-hole ceramic tube, the thick single-hole ceramic tube, the thin single-hole ceramic tube and the tungsten filament made of aluminum oxide which is common in market can bear plume temperature of the magnetic plasma thrustor; structural stability can be kept through clearance fit; and the cylindrical probe is simple in structure.

A compensated flow measuring system for measuring a multi-phase fluid flow in a well. An impeller intercepts a downhole multi-phase flow. Capacitance and conductivity sensors are mounted in close proximity to the impeller and provide a measure of electrical admittance of the fluid. In one embodiment, the capacitance and conductivity sensors are mounted in at least one single probe mounted near the impeller. An electronics system contains a phase detector for separating the capacitive and conductive signals and providing a signal related to a compensated multiphase flow rate.