Preparation of high drug loading multifunction nanometer drug with combination treatment effect
A technology with high drug loading and therapeutic effect, applied in the direction of drug combinations, inorganic non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of carrier biotoxicity, metabolism in the body, and low drug loading, and achieve Good repeatability, easy operation, simple and easy operation effect
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[0030] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.
[0031] The preparation of the multifunctional nanomedicine with combined therapeutic effect of high drug loading is characterized in that it comprises the following steps:
[0032] Step 1) Prepare hydrophobic organic anticancer drug molecules into precursor nanoparticle suspension by solvent exchange method; the specific method is to dissolve the organic anticancer drug molecules in a good solvent to prepare an organic anticancer drug molecule solution , taking an appropriate volume of the organic anticancer drug molecular solution and adding it to an appropriate amount of poor solvent, stirring magnetically for 5 minutes and then standing still to obtain a precursor nanoparticle suspension;
[0033] Step 2) Add an appropriate volume of 1 mg / mL cationic surfactant aqueous solution to the suspension of the precursor nanoparticles, and...
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