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Preparation method of high drug loading rod-shaped nanometer drug for cancer treatment

A nano-drug, high drug-loading technology, applied in the directions of drug combination, anti-tumor drugs, emulsion delivery, etc., can solve the problems of in vivo metabolism, carrier biotoxicity, low drug-loading capacity, etc. Reproducible results with high sample purity

Inactive Publication Date: 2013-08-21
SUZHOU UNIV
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Problems solved by technology

The existence of a large number of carriers will bring many serious problems, such as low drug loading, possible carrier biotoxicity and metabolism problems in the body, etc., which greatly limits its application.

Method used

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  • Preparation method of high drug loading rod-shaped nanometer drug for cancer treatment
  • Preparation method of high drug loading rod-shaped nanometer drug for cancer treatment
  • Preparation method of high drug loading rod-shaped nanometer drug for cancer treatment

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Embodiment Construction

[0030] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0031] A method for preparing a rod-shaped nanomedicine with high drug loading for cancer treatment, characterized in that it comprises the following steps:

[0032] Step 1) Prepare hydrophobic organic anticancer drug molecules into precursor nanofiber suspension by solvent exchange method; the specific method is to dissolve the organic anticancer drug molecules in a good solvent to prepare an organic anticancer drug molecule solution, Take an appropriate volume of the organic anticancer drug molecular solution and add it to an appropriate amount of poor solvent, stir magnetically for 5 minutes and then let stand to obtain a precursor nanofiber suspension;

[0033] Step 2) Sonicate the prepared precursor nanofiber suspension, and obtain a rod-shaped nanomedicine suspension with a dimension of 250-400 / 40-60 nm by controlling the ultraso...

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Abstract

The invention discloses a preparation method of a high drug loading rod-shaped nanometer drug for cancer treatment, wherein an oversaturation degree of a hydrophobic anti-cancer drug in water, and a nanometer fiber suspension ultrasonic time are controlled, and a hydrophobic interaction between an amphiphilic surfactant and the surface of a rod-shaped nanometer drug is adopted to modify the surface of the nano-rod so as to achieve preparation of high drug loading hydrophobic rod-shaped nanometer drug with characteristics of cancer treatment and stable bioenvironment. With the technical scheme, the preparation method is simple, experimental basis is provided for preparation of other high drug loading hydrophobic anti-cancer non-spherical nanometer materials with characteristics of cancer treatment and stable bioenvironment, and wide applications can be provided for the fields of biology, medicine, chemistry and the like.

Description

technical field [0001] The invention belongs to a method for preparing a hydrophobic organic rod-shaped nano-medicine with high drug loading and stable biological environment for cancer treatment, in particular, the invention relates to a high drug-load rod for cancer treatment Preparation method of shaped nanomedicine. Background technique [0002] Cancer has become one of the major diseases threatening human health. Effective treatment of cancer has become a top priority in scientific research. Chemotherapy is one of the indispensable and important methods in tumor treatment. However, due to the low water solubility, limited stability, rapid blood clearance and lack of selective entry into the body, most chemotherapeutic drugs currently used clinically It is distributed not only in tumor tissues but also in normal tissues. While killing tumor cells, it also damages normal human tissue cells, resulting in low curative effect and strong side effects. Therefore, enhancing ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61P35/00
Inventor 张秀娟李伟
Owner SUZHOU UNIV
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