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Preparation method for core-shell structure drug carrier for real-time monitoring drug release through near-infrared light stimulation

A core-shell structure and real-time monitoring technology, which is applied to the photodissociation of drugs in the body, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of inability to effectively monitor drug release, and achieve a wide range of applications , Avoid biological toxicity, high precision effect

Active Publication Date: 2016-11-09
黑龙江省工研院资产经营管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problem that the drug release platform cannot effectively monitor the release amount of the drug, the present invention provides a method for preparing a drug carrier with a core-shell structure that is excited by near-infrared light to monitor drug release in real time

Method used

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  • Preparation method for core-shell structure drug carrier for real-time monitoring drug release through near-infrared light stimulation
  • Preparation method for core-shell structure drug carrier for real-time monitoring drug release through near-infrared light stimulation
  • Preparation method for core-shell structure drug carrier for real-time monitoring drug release through near-infrared light stimulation

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specific Embodiment approach 1

[0030] Embodiment 1: The method for preparing a drug carrier with a core-shell structure that is excited by near-infrared light and monitors drug release in real time in this embodiment is specifically carried out according to the following steps:

[0031] 1. Synthesis of the upconversion nanoparticle core: mix yttrium chloride hexahydrate, ytterbium chloride hexahydrate and thulium chloride hexahydrate to obtain a mixture, then add oleic acid and octadecene to the mixture for reaction, and protect the mixture under argon Under the condition of stirring, the reaction temperature was raised from room temperature to 160 ° C, and stirred for 1 h under the protection of argon and the temperature was 160 ° C, and then the temperature was naturally cooled from 160 ° C to 50 ° C, then the mixed solution A was added, and Stir for 40min under the protection of argon and a temperature of 50°C, then raise the temperature from 50°C to 75°C, and keep it for 30min under the protection of arg...

specific Embodiment approach 2

[0042] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the volume ratio of the mass of lutetium chloride hexahydrate described in step two to oleic acid is 1mg:0.067mL. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0043] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the volume ratio of the mass of lutetium chloride hexahydrate described in step two to octadecene is 1mg:0.125mL. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention relates to a preparation method for a core-shell structure drug carrier for real-time monitoring drug release through near-infrared light stimulation. The invention belongs to the field of a biomedical material and specifically relates to the preparation method for the core-shell structure drug carrier for real-time monitoring drug release through near-infrared light stimulation. The invention aims to solve the problem that the drug release platform cannot effectively monitor the release amount of the drug. The method comprises the following steps: 1) synthesizing an up-conversion nanometer particle core; 2) synthesizing an up-conversion nanometer particle coating the outer shell; 3) coating the outer layer of the up-conversion nanometer particle with mesoporous silica; 4) synthesizing 4-oxy-4-(pyrene-4-methoxy) butyrate; 5) performing functional decoration on the nanometer particle surface; 6) carrying drug on the nanometer particle and plugging the duct. The preparation method is applied to the cancer therapy and can realize the real-time monitoring for anti-cancer drug release.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a drug carrier with a core-shell structure that is excited by near-infrared light and monitors drug release in real time. Background technique [0002] With the rapid development of nanomedicine, the design and construction of an intelligent responsive drug controlled release platform can deliver anticancer drugs to cancer cells without leakage, and release the drug at a designated time and place, reducing the damage of drugs to normal cells. Improving treatment efficiency has become an important development direction of nanomedicine science. At present, the intelligent response controlled release platforms reported in the literature mainly include: pH, temperature, enzyme, light response and so on. Among them, pH, temperature, and enzymes are in vivo responses, and the response sensitivity is poor, so it is difficult to precisely control th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/50A61K47/04A61K47/14A61K47/40
CPCA61K9/501A61K9/5015A61K41/0042A61K47/40
Inventor 刘宗俊王铀
Owner 黑龙江省工研院资产经营管理有限公司
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