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Modified polyvinyl alcohol cornea repair material with collagen in graded distribution and preparation method

A technology of polyvinyl alcohol cornea and gradient distribution, applied in medical science, prostheses, etc., can solve the problems of lack of biological activity, poor cell adhesion, etc., and achieve the effect of simple equipment, simple preparation process, and excellent light transmission

Inactive Publication Date: 2015-11-11
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyvinyl alcohol still has certain disadvantages as a biomaterial, such as lack of biological activity and poor cell adhesion, which limit the application of polyvinyl alcohol to a certain extent.

Method used

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  • Modified polyvinyl alcohol cornea repair material with collagen in graded distribution and preparation method
  • Modified polyvinyl alcohol cornea repair material with collagen in graded distribution and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Polyvinyl alcohol (the degree of alcoholysis is 95%, and the weight average molecular weight Mw is 9000) is formulated with deionized water into a polyvinyl alcohol solution with a mass fraction of 10%, at a temperature of 90 to 98°C and a pressure of 600mmHg Remove air bubbles under vacuum conditions, and let stand at 90-98°C for 1.5 hours, then cool at room temperature, when the temperature of the polyvinyl alcohol solution is 50°C-60°C, pour 5ml of polyvinyl alcohol solution to a diameter of 1.5 cm disc mold, and pave it flat, freeze the mold at -20°C for 16 hours to obtain a frozen polyvinyl alcohol solution;

[0032] (2) Take the mold together with the frozen polyvinyl alcohol solution out of the -20°C environment and place it in a 25°C environment, and quickly spread 1ml of collagen solution evenly on the surface of the frozen polyvinyl alcohol solution (mass volume concentration is 4.0mg / ml of type I collagen acetic acid solution), and then thawed at 25°C fo...

Embodiment 2

[0041] (1) Polyvinyl alcohol (alcoholysis degree is 96%, weight-average molecular weight Mw is 9500) is mixed with deionized water into a polyvinyl alcohol solution with a mass fraction of 15%, at a temperature of 90 to 98°C and a pressure of 600mmHg Under the condition of vacuum to remove air bubbles, let stand at 90-98°C for 1 hour, then cool at room temperature, when the temperature of the polyvinyl alcohol solution is 50°C-60°C, pour 10ml of polyvinyl alcohol solution to a diameter of 1.5 cm disc mold, and lay it flat, and freeze the mold at -20°C for 16 hours to obtain a frozen polyvinyl alcohol solution;

[0042] (2) Take the mold together with the frozen polyvinyl alcohol solution out of the -20°C environment and place it in a 25°C environment, and quickly apply 10ml of collagen solution evenly on the surface of the frozen polyvinyl alcohol solution (mass volume concentration is 10mg / ml Type I collagen acetic acid solution), and then thawed at 25°C for 8 hours to obtain...

Embodiment 3

[0047] (1) Polyvinyl alcohol (the degree of alcoholysis is 97%, and the weight average molecular weight Mw is 10000) is formulated with deionized water into a polyvinyl alcohol solution with a mass fraction of 20%, at a temperature of 90 to 98°C and a pressure of 600mmHg Remove air bubbles under vacuum conditions, and let stand at 90-98°C for 2 hours, then cool at room temperature, when the temperature of the polyvinyl alcohol solution is 50°C-60°C, pour 10ml of polyvinyl alcohol solution to a diameter of 1.5 cm disc mold, and pave it flat, freeze the mold at -20°C for 16 hours to obtain a frozen polyvinyl alcohol solution;

[0048] (2) Take the mold together with the frozen polyvinyl alcohol solution out of the -20°C environment and place it in an environment of 25°C, and quickly apply 5ml of collagen solution evenly on the surface of the frozen polyvinyl alcohol solution (mass volume concentration is 15mg / ml Type I collagen acetic acid solution), and then thawed at 25°C for ...

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Abstract

The invention belongs to the technical field of biomedical materials and discloses a modified polyvinyl alcohol cornea repair material with collagen in graded distribution and a preparation method. The preparation method comprises the steps of preparing polyvinyl alcohol into a polyvinyl alcohol solution by utilizing deionized water, performing defoaming and then pouring the polyvinyl alcohol solution in a die to be laid flatly and frozen; evenly coating the surface of the frozen polyvinyl alcohol solution with a collagen solution under the conditions of room temperature, performing unfreezing at room temperature, and obtaining a compound system of polyvinyl alcohol and collagen; repeating the freezing and unfreezing process of the compound system 7-10 times, finally performing natural air drying, and obtaining the modified polyvinyl alcohol cornea repair material with collagen in graded distribution. The content of collagen in the cornea repair material is in graded distribution, biological activities on the two sides of the material are different, the requirements of a cornea layered structure are met in function, and the modified polyvinyl alcohol cornea repair material and the preparation method have good application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a collagen gradient distribution modified polyvinyl alcohol corneal repair material and a preparation method. Background technique [0002] The cornea is a transparent tissue located at the front of the eyeball and is susceptible to infection and trauma. Corneal diseases (such as leukoplakia, keratoconus, corneal ulcer or trauma, etc.) make the cornea change from transparent to cloudy and affect the patient's vision. Corneal transplantation is one of the effective ways to treat corneal diseases, and allograft transplantation has the best effect. It is currently the first choice for the treatment of corneal ulcers, corneal opacity and other diseases. Due to the limitation of allogeneic corneal donors, corneal repair materials have become a research hotspot. [0003] At present, there are many methods for preparing corneal repair materials at home and abr...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08L89/00A61L27/48A61L27/26
Inventor 任力王迎军龙凯
Owner SOUTH CHINA UNIV OF TECH
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