34 results about "Cornea repair" patented technology

The invention discloses a surface functionalized chitosan cornea rehabilitating material and a preparation method thereof. The method comprises the following steps: dissolving chitosan into acid solution; injecting the chitosan solution into a mould to be dried; and drying the chitosan solution after being processed in alkali solution to obtain chitosan cornea. Biomacromolecule and short peptide are fixed on the surface of the chitosan cornea by adopting the chemical crosslinking method. The contact angle of the surface functionalized chitosan cornea declines obviously and the hydrophilic property is improved. The prepared surface functionalized chitosan cornea rehabilitating material has over 95 percent of light transmission, good cell compatibility and biologic compatibility, can be used for rehabilitating corneal damage in medical fields, and has the advantages of simple preparation process, simple equipment, cheap and accessible raw materials, good application prospect and scientific value.

The invention relates to the technical field of medical biomaterials, in particular to a culture medium, a corneal stroma sheet prepared by it and a preparation method. The medium provided by the invention is a DMEM / F12 medium containing porcine corneal extract, Y-27632, ITS, FGF, ascorbic acid and fetal calf serum. Compared with the corneal stromal cells and corneal stromal sheets prepared by the traditional culture medium, the present invention has the ability to maintain keratocytes by selecting appropriate active components and proportioning ratios. Phenotype, promote proliferation, improve vitality, anti-fibrosis and anti-apoptosis and other functions. The corneal stroma sheet of the present invention is prepared by using corneal lens as a raw material and cultured in the medium. Compared with animal-derived corneal repair materials, it has good biocompatibility and no antigenicity, and can be used for various supplies of corneal transplantation. It is an alternative to body materials, which can be accepted by a large number of patients and used in clinical practice for a long time.

The invention discloses a preparation method of a cornea repair graft with biological activity and the cornea repair graft, and solves the technical problem of deficiency of cornea donors. The preparation method comprises the following steps: preparing collagen dispersion; preparing a collagen membrane on the basis of the collagen dispersion; adding surface functionalization modified substances on the surface of the collagen membrane in a 3D printing or coating mode under the sterile condition to form the cornea repair graft with biological activity. The surface functionalization modified substances are fine particles which are prepared from a cornea stroma, which does not contain a lesion part and contains active cells, of a patient, the biology and the biological stability of the high-strength collagen membrane can be improved, the physiological function of cornea is improved, after the modified collagen membrane is implanted into an eye of the patient, transparency and moisture content are good, the transparency can be recovered quickly clinically, the biological compatibility is good, and a good stent is provided for cornea cell culture of a cornea transplantation receptor.

The present invention relates to the application of a short-chain peptide composition in preventing or treating dry eye. The short-chain peptide composition of the present invention comprises a short-chain peptide composed of 5-10 amino acids, and has the effects of promoting corneal repair, increasing eye humidity and improving dry eye syndrome.

The invention discloses a preparation method for an antifungal cornea repairing material. The preparation method comprises the following steps: (1) preparing a saturated solution of dialdehyde beta-cyclodextrin, adding a medicine and carrying out a full reaction so as to obtain a dialdehyde beta-cyclodextrin / medicine inclusion complex; (2) extracting I type collagen, subjecting the extracted I type collagen to freeze-drying and dissolving the freeze-dried I type collagen in an acetic acid or hydrochloric acid solution to prepare a collagen solution; (3) adding the inclusion complex obtained inthe step (1) as a cross-linking agent into the collagen solution to remove bubbles in the solution; and (4) casting the cross-linked collagen solution to a cornea-repairing-material forming die for film formation. The material prepared by using the method has high transparency, good mechanical properties, and temperature-sensitive release properties, is obviously different in releasing effect atdifferent temperatures, and can be used for different medical fields.

The present invention relates to an ophthalmic product with cornea repair function. The ophthalmic product having a cornea repair function includes an ophthalmic composition. The ophthalmic composition includes gold nanoparticles serving as the main repairing ingredient and at least one auxiliary repairing ingredient. An effective concentration of the gold nanoparticles is from 0.01 ppm to 3000 ppm. The content of the at least one auxiliary repairing ingredient is greater than 0 wt % and less than 20 wt % based on 100 wt % of the ophthalmic composition. The ophthalmic product can enhance the protection and repairing capacity of cells in each layer of tissues of the eyes, and can improve the wearing comfort of the contact lenses.