Application of short-chain peptide composition in the prevention or treatment of dry eye
A technology for dry eye syndrome and composition, which is applied in the field of short-chain peptide composition, which can solve the problems of patients with serious conditions, achieve the effects of increasing eye moisture, improving acute and long-term dry eye syndrome, and promoting corneal repair
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Embodiment 1
[0017] Embodiment 1. Short-chain peptide composition promotes corneal repair of eyes
[0018] In this example, 500 μl of hydrochloric acid (0.12N, pH=2) was used to corrode the cornea of rabbits, resulting in decreased eye humidity. A 14-day rabbit dry eye experiment was performed to evaluate the efficacy of AE250 on dry eye protection. The drug is AE250 dripped 4 times a day, 200μl / time is only dripped for 7 days, and the drip of AE250 is stopped on the 8th day; the eye humidity test of the left / right eye is done. The result is as figure 1 shown.
[0019] Depend on figure 1 The results showed that after the rabbit eyes stopped instilling AE250 on the 8th day, compared with the injury group, an increase in eye humidity of 40-50% could indeed improve dry eye syndrome. After the rabbit eyes stopped dripping AE250 on the 8th day, compared with the injury group, AE250 could indeed last for 7 days, which significantly improved the acute dry eye of rabbits. It is confirmed tha...
Embodiment 2
[0023] Embodiment 2. Short-chain peptide composition improves acute dry eye
[0024] Rabbit eyes are the most sensitive among animals, so this example uses rabbits for acute dry eye experiments. Tropicamide is a short-acting ciliary muscle relaxant that inhibits the physiological activity of the parasympathetic nerves of the eye. Tears are controlled by parasympathetic nerves, so inhibition of parasympathetic nerves inhibits tear secretion, which can be used to cause acute dry eye in rabbits. Establishment of an animal test model for dry eye: Tropicamide (0.4% solution in normal saline to antagonize the parasympathetic M3 receptor) was administered to the eyes of rabbits 5 times in 12 hours , 1 hour after the last drop of the rabbit eye, drop the test drug: TOPICAMIDE group, dropwise add normal saline without short-chain peptide; TOPICAMIDE+AE250 group, dropwise add AE250-containing Physiological saline of the peptide composition. One hour after dropping the test drug, the ...
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