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Application of short-chain peptide composition in the prevention or treatment of dry eye

A technology for dry eye syndrome and composition, which is applied in the field of short-chain peptide composition, which can solve the problems of patients with serious conditions, achieve the effects of increasing eye moisture, improving acute and long-term dry eye syndrome, and promoting corneal repair

Active Publication Date: 2022-07-05
PRO SUNFUN BIOTECH RES & DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treatment methods for dry eye syndrome mostly use artificial tear drops and artificial tear ointment, most of which are temporarily effective, but many patients are still getting more and more serious

Method used

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  • Application of short-chain peptide composition in the prevention or treatment of dry eye
  • Application of short-chain peptide composition in the prevention or treatment of dry eye
  • Application of short-chain peptide composition in the prevention or treatment of dry eye

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Embodiment 1. Short-chain peptide composition promotes corneal repair of eyes

[0018] In this example, 500 μl of hydrochloric acid (0.12N, pH=2) was used to corrode the cornea of ​​rabbits, resulting in decreased eye humidity. A 14-day rabbit dry eye experiment was performed to evaluate the efficacy of AE250 on dry eye protection. The drug is AE250 dripped 4 times a day, 200μl / time is only dripped for 7 days, and the drip of AE250 is stopped on the 8th day; the eye humidity test of the left / right eye is done. The result is as figure 1 shown.

[0019] Depend on figure 1 The results showed that after the rabbit eyes stopped instilling AE250 on the 8th day, compared with the injury group, an increase in eye humidity of 40-50% could indeed improve dry eye syndrome. After the rabbit eyes stopped dripping AE250 on the 8th day, compared with the injury group, AE250 could indeed last for 7 days, which significantly improved the acute dry eye of rabbits. It is confirmed tha...

Embodiment 2

[0023] Embodiment 2. Short-chain peptide composition improves acute dry eye

[0024] Rabbit eyes are the most sensitive among animals, so this example uses rabbits for acute dry eye experiments. Tropicamide is a short-acting ciliary muscle relaxant that inhibits the physiological activity of the parasympathetic nerves of the eye. Tears are controlled by parasympathetic nerves, so inhibition of parasympathetic nerves inhibits tear secretion, which can be used to cause acute dry eye in rabbits. Establishment of an animal test model for dry eye: Tropicamide (0.4% solution in normal saline to antagonize the parasympathetic M3 receptor) was administered to the eyes of rabbits 5 times in 12 hours , 1 hour after the last drop of the rabbit eye, drop the test drug: TOPICAMIDE group, dropwise add normal saline without short-chain peptide; TOPICAMIDE+AE250 group, dropwise add AE250-containing Physiological saline of the peptide composition. One hour after dropping the test drug, the ...

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Abstract

The present invention relates to the application of a short-chain peptide composition in preventing or treating dry eye. The short-chain peptide composition of the present invention comprises a short-chain peptide composed of 5-10 amino acids, and has the effects of promoting corneal repair, increasing eye humidity and improving dry eye syndrome.

Description

technical field [0001] The present invention relates to a short-chain peptide composition for preventing or treating dry eye. More particularly, the present invention relates to a short-chain peptide comprising one or more oligopeptides whose structure is an oligopeptide having 5 to 10 amino acids selected from a combination of Serine and Lysine and other amino acids Composition for promoting corneal repair, increasing eye moisture and improving dry eye. Background technique [0002] Dry eye disease (DED), also known as keratoconjunctivitissicca (KCS), is a condition of dry eyes, mainly due to insufficient or uneven distribution of tears in the eyes or excessive tear evaporation , causing tears to properly keep the surface of the eye moist. Common symptoms include dry eyes, easy fatigue, foreign body sensation, burning sensation, tight and heavy eyelids, thick secretions, fear of wind, photophobia, and in severe cases, the eyes will be red, swollen, hyperemia, keratinized,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/08A61P27/02A61P27/04
CPCA61K38/08A61P27/02A61P27/04
Inventor 侯建维李英中贾铜安戴瑞凡
Owner PRO SUNFUN BIOTECH RES & DEV CO LTD
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