Preparation method for antifungal cornea repairing material
A repair material and anti-fungal technology, applied in the field of materials, can solve the problems of lack of corneal materials, unsatisfactory prognosis of fungal keratitis, unsatisfactory clinical treatment, etc., and achieve the effect of high transparency and good mechanical properties
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Embodiment 1
[0026] The β-cyclodextrin dialdehyde / voriconazole inclusion compound prepared by freeze-drying method was used as a cross-linking agent to cross-link collagen to prepare a collagen membrane material containing antifungal drugs. The preparation steps of this collagen membrane material are as follows:
[0027] (1) Add β-cyclodextrin dialdehyde into deionized water and stir at 60°C to form a saturated solution, then add voriconazole (molar ratio 1:1) after stirring, fully react at constant temperature for 2 hours, freeze-dry, dissolve in acetone, and pump Filter and dry to obtain β-cyclodextrin dialdehyde / voriconazole inclusion compound (β-CD-DA / Vor);
[0028] (2) Freeze-dry the type I collagen extracted from bovine Achilles tendon, and dissolve it with acetic acid or hydrochloric acid to prepare a collagen solution with a concentration of 4-8 mg / mL;
[0029] (3) Add the clathrate obtained in step (1) into the collagen solution as a cross-linking agent. The amount of the cross-l...
Embodiment 2
[0033] The β-cyclodextrin dialdehyde / voriconazole inclusion compound prepared by saturated aqueous solution was used as a cross-linking agent to cross-link collagen, and a collagen membrane material containing antifungal drugs was prepared. The preparation steps of this collagen membrane material are as follows:
[0034] (1) Add β-cyclodextrin dialdehyde to deionized water to make a saturated solution at 30°C, stir and add voriconazole (molar ratio 1:1), keep it still at constant temperature for 1 hour, and filter off the supernatant , suction filtration and drying to obtain β-CD-DA / Vor clathrate;
[0035] (2) Freeze-dry the type I collagen extracted from bovine Achilles tendon, and dissolve it with acetic acid or hydrochloric acid to prepare a collagen solution with a concentration of 8 mg / mL;
[0036] (3) Add the clathrate obtained in step (1) into the collagen solution as a cross-linking agent, the amount of the cross-linking agent accounts for 5% of the collagen mass, sti...
Embodiment 3
[0040] The β-cyclodextrin dialdehyde / voriconazole inclusion compound prepared by ultrasonic method was used as a cross-linking agent to cross-link collagen to prepare a collagen membrane material containing antifungal drugs. The preparation steps of this collagen membrane material are as follows:
[0041] (1) Add β-cyclodextrin dialdehyde to deionized water at room temperature and ultrasonically make a saturated solution, then add voriconazole (molar ratio 1:0.5) ultrasonically, react at a constant temperature for 60 minutes, let it stand still, filter the supernatant, suction filter, Dry to obtain β-CD-DA / Vor clathrate;
[0042] (2) Freeze-dry the type I collagen extracted from bovine Achilles tendon, and dissolve it with acetic acid or hydrochloric acid to prepare a collagen solution with a concentration of 4 mg / mL;
[0043] (3) Add the clathrate obtained in step (1) into the collagen solution as a cross-linking agent, the amount of the cross-linking agent accounts for 30% ...
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