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Electrochemical method for preparing chitosan tetracycline coating on surface of metallic implant

An implant, tetracycline technology, applied in the direction of coating, prosthesis, medical science, etc., to avoid toxic side effects, wide range of indications, mild preparation conditions

Inactive Publication Date: 2011-04-13
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (patent application number: 201010160657.6), but the biological coating constructed on the surface of titanium implants by this method does not have antibacterial function

Method used

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  • Electrochemical method for preparing chitosan tetracycline coating on surface of metallic implant
  • Electrochemical method for preparing chitosan tetracycline coating on surface of metallic implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Prepare chitosan tetracycline mixed solution containing 0.1g / L tetracycline:

[0034] 1) Weigh 1 g of chitosan, dissolve in 100 mL of acetic acid solution, and magnetically stir until completely dissolved;

[0035] 2) Add 0.01g tetracycline under the condition of avoiding light, and magnetically stir until completely dissolved;

[0036] 3) The pH value of the above mixed solution is 3.3.

[0037] 2. Electrodeposition reaction:

[0038] 1) The platinum sheet is used as the anode, the titanium implant is used as the cathode, and the chitosan tetracycline mixed solution is used as the electrodeposition solution;

[0039] 2) The anode and cathode are immersed in the electrodeposition solution, and the distance between the two electrodes is 5cm;

[0040] 3) Control the energized direct current between the two electrodes to 1A / cm 2

[0041] 4) After 2 minutes of deposition, a layer of chitosan tetracycline coating with excellent combination with it was formed on the...

Embodiment 2

[0046] 1. Prepare chitosan tetracycline mixed solution containing 1g / L tetracycline:

[0047] 1) Weigh 1 g of chitosan, dissolve it in 100 mL of acetic acid solution, and stir until completely dissolved.

[0048] 2) Add 0.1g of tetracycline under the condition of avoiding light, and magnetically stir until completely dissolved.

[0049] 3) The pH value of the above mixed solution is 3.2.

[0050] 2. Electrodeposition reaction:

[0051] 1) The platinum sheet is used as the anode, the titanium alloy (TiAlV) implant is used as the cathode, and the chitosan tetracycline mixed solution is used as the electrodeposition solution;

[0052] 2) The anode and cathode are immersed in the electrodeposition solution, and the distance between the two electrodes is 5cm;

[0053] 3) Control the energized direct current between the two electrodes to be 4A / cm 2 ;

[0054] 4) After 2 minutes of deposition, a layer of chitosan tetracycline coating with excellent combination with it is forme...

Embodiment 3

[0059] 1. Prepare chitosan tetracycline mixed solution containing 10g / L tetracycline:

[0060] 1) Weigh 1 g of chitosan, dissolve it in 100 mL of hydrochloric acid solution, and stir until completely dissolved.

[0061] 2) Add 1g of tetracycline under the condition of avoiding light, and magnetically stir until completely dissolved.

[0062] 3) The pH value of the above mixed solution is 2.7.

[0063] 2. Electrodeposition reaction:

[0064] 1) The platinum sheet is used as the anode, the stainless steel implant is used as the cathode, and the chitosan tetracycline mixed solution is used as the electrodeposition solution;

[0065] 2) The anode and cathode are immersed in the electrodeposition solution, and the distance between the two electrodes is 5cm;

[0066] 3) Control the energized DC voltage between the two electrodes to 1V / cm 2 ;

[0067] 4) After 2 minutes of deposition, a layer of chitosan tetracycline coating with excellent combination with it is formed on the ...

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Abstract

The invention discloses an electrochemical method for preparing a chitosan tetracycline coating on a surface of a metallic implant. The coating prepared by the method has favorable biocompatibility and bacteriostasis, and further presents the potential to be developed into a novel medical hard tissue implanted material. In the electrochemical method of the invention, chitosan tetracycline is assembled on the material surface. The method comprises the following steps: preparing mixed electrolytic deposition liquid containing chitosan and tetracycline; and immersing a platinum sheet as an anode and a metallic implant as a cathode into the electrolytic deposition liquid for electrolytic deposition reaction, and leading the chitosan and the tetracycline to co-precipitate on the surface of the metallic implant. The electrochemical method has the advantages of simple preparation method, controllable coating thickness, free of limitation of sizes and shapes of materials, suitability for materials with complicated sizes and shapes, mild preparation conditions, low production cost, strong practicability and good popularization and application values.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a method for constructing a biological antibacterial coating on the surface of a metal implant. Background technique [0002] At present, titanium, titanium alloys and stainless steel materials are widely used in the field of biomedical materials. They all have good bone cell compatibility and comprehensive biomechanical properties, so they can be used as hard tissue replacement materials for dental implants, joint replacements, bone fixation, and bone reconstruction. However, these metal materials are all inert materials, and can only form mechanical bonds with bone tissue instead of biological bonds. At the same time, because they do not have antibacterial properties, after implantation, bacteria tend to gradually migrate along the joint between the implant and the bone. Deep invasion causes peri-implant inflammation, loss of supporting bone around the implant, resulting ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/02A61L27/34A61L27/54A61L27/06
Inventor 蒋滔张贞王贻宁蔡新杰
Owner WUHAN UNIV
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