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235results about How to "Undesirable effect" patented technology
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Passivation processing over a memory link
InactiveUS6887804B2Improve processing qualityAvoid and minimize substrate damage and undesirable damageSemiconductor/solid-state device detailsSolid-state devicesEtchingHarmonic
A set (50) of one or more laser pulses (52) is employed to remove passivation layer (44) over a conductive link (22). The link (22) can subsequently be removed by a different process such as chemical etching. The duration of the set (50) is preferably shorter than 1,000 ns; and the pulse width of each laser pulse (52) within the set (50) is preferably within a range of about 0.05 ps to 30 ns. The set (50) can be treated as a single “pulse” by conventional laser positioning systems (62) to perform on-the-fly material removal without stopping whenever the laser system (60) fires a set (50) of laser pulses (52) at each target area (51). Conventional wavelengths in the IR range or their harmonics in the green or UV range can be employed.
Owner:ELECTRO SCI IND INC
Methods and compositions for treatment of skin disorders
ActiveUS20110171227A1Undesirable effectImproving disease reductionSnake antigen ingredientsAntibody ingredientsEtanerceptPrior biologic therapy
The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNFα activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNFα antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis.
Owner:ABBVIE BIOTECHNOLOGY LTD
Getters for thin film battery hermetic package
InactiveUS20080003493A1Expand on chargeImprove hermetic sealingSolid electrolytesFinal product manufactureGetterEngineering
A method for improving the useful life of a thin film lithium-ion battery containing a solid electrolyte and an anode that expands on charging and long life batteries made by the method. The method includes providing a hermetic barrier package for the thin film battery that includes an anode expansion absorbing structure and at least one film getter.
Owner:OAK RIDGE MICRO ENERGY
Inspection method and apparatus for the inspection of either random or repeating patterns
InactiveUS6021214AHighest-performance and most flexibleMore precisionImage enhancementImage analysisFrequency domainLow complexity
The present invention is a hybrid technique for finding defects on digitized device images using a combination of spatial domain and frequency domain techniques. The two dimensional spectra of two images are found using Fourier like transforms. Any strong harmonics in the spectra are removed, using the same spectral filter on both spectra. The images are then aligned, transformed back to the spatial domain, and subtracted. The resulting spectrally-filtered difference image is thresholded and analyzed for defects. Use of the hybrid technique of the present invention to process digitized images results in the highest-performance and most flexible defect detection system. It is the best performer on both array and random devices, and it can cope with problems such as shading variations and the dark-bright problem that no other technique can address. The hybrid technique of the present invention also uses frequency domain techniques to align the images with fewer errors than spatial domain techniques of similar or lesser complexity. Further, the relative offsets of the pairs of images are determined by frequency domain techniques--and this method may be the most accurate and the least expensive.
Owner:KLA INSTR
Micromachined Gyroscopes with 2-DOF Sense Modes Allowing Interchangeable Robust and Precision Operation
ActiveUS20110094302A1Eliminate undesirable scale effectUndesirable effectAcceleration measurement using interia forcesSpeed measurement using gyroscopic effectsSense modeFully coupled
A z-axis gyroscope design is presented with a 2-degree of freedom (DOF) sense mode allowing interchangeable operation in either precision (mode-matched) or robust (wide-bandwidth) modes. This is accomplished using a complete 2-DOF coupled system which allows for the specification of the sense mode resonant frequencies and coupling independent of frequency. By decoupling the frame connecting the sense system to a central anchor, x-y symmetry is preserved while enabling a fully coupled 2-DOF sense mode providing control over both the bandwidth and the amount of coupling independent of operational frequency. The robust mode corresponds to operation between the 2-DOF sense mode resonant frequencies providing a response gain and bandwidth controlled by frequency spacing. Precision mode of operation, however, relies on mode-matching the drive to the second, anti-phase sense mode resonant frequency which can be designed to provide a gain advantage over a similar 1-DOF system.
Owner:RGT UNIV OF CALIFORNIA
Control of intraocular pressure using ALK5 modulation agents
InactiveUS20070142376A1Increase productionIncreased IOP in vivoBiocideSenses disorderIntraocular pressureTreatment glaucoma
An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure comprising an effective amount of a selective modulator of ALK5 receptor activity is disclosed. Also disclosed is a method of treating glaucoma and controlling intraocular pressure comprising applying a therapeutically effective amount of a pharmaceutical composition comprising a selective modulator of ALK5 receptor activity to an affected eye of a patient.
Owner:ALCON INC
Method and apparatus for opto-thermo-mechanical treatment of biological tissue
InactiveUS20050119643A1Increase and decrease abilityEfficiency of influenceElectrotherapyControlling energy of instrumentOptical radiationControl signal
The invention relates to a method and apparatus for opto-thermo-mechanical treatment of biological tissue. A biological tissue area 8 is irradiated with a radiation in the optical wavelength range with predetermined parameters, the radiation being modulated and spatially formed under a predetermined law; the irradiation is accompanied by simultaneous thermal and mechanical treatment of the area 8; concurrently with the irradiation of the biological tissue area, spatial distribution of physico-chemical and geometrical characteristics is measured both in the zone of direct optical treatment and in close vicinity, using a control diagnostic system 4; a data processing unit 7 coordinates parameters of optical radiation spatial formation and modulation with each other and with the biological tissue characteristics and provides a control signal to an optical radiation power and time modulation control unit 2 and a device 3 for delivering optical radiation and forming spatial distribution of optical radiation power on the surface and in the bulk of the biological tissue 8. Optical radiation parameters are adjusted responsive to control signals of the control-diagnostic system 4 during irradiation as a function of continuously changing characteristics of spatial distribution of physico-chemical and geometrical characteristics both in and beyond the directly treated biological tissue area.
Owner:ARCUO MEDICAL
Pouch-Equipped Intragastric Balloon
An expandable intragastric balloon comprising a first flexible pouch (2) comprising a port; a second pouch (20) which contains the first pouch (2) and which is equipped with a hole (21); and, a sealing member (4) which is hermetically fixed to the second pouch (20) and which is intended to seal the port and the hole (21). The first and second pouches (2, 20) are produced from different, non-compatible materials and are assembled with the aid of a fixing element (7). The fixing element is designed to ensure that the sealing member (4) is hermetically fixed to the first pouch (2) inside a passage (6) that is defined by a neck (5) which extends from the port, such that sufficient pressure is exerted on the neck (5) in order for same to be pinched between the sealing member (4) and the fixing element (7).
Owner:CIE EURO D'ETUDES & DE RECH DE DISPOSITIFS POUR L'IMPLANTATION PAR LAPAROSCOPIE
Surgical System Having Means for Pressurizing Venting Valve
InactiveUS20090163853A1MinimizationEffective preventionEye surgeryMedical devicesEngineeringCatheter
The present invention provides a surgical system 10 for aspiration of a biological material comprising a source of irrigation fluid 24, a collection cassette 30, a pump 40 for creating a vacuum in the collection cassette 30, a handpiece 50 applied to a surgical area for infusing irrigation fluid and for aspirating a biological material, conduits 60 and 62 connecting the handpiece to each of the source of irrigation fluid and the collection cassette and means 70 for isolating the pump from the handpiece to prevent creation of vacuum within the conduit 62 and the collection cassette 30 after receiving a stop signal.
Owner:BAUSCH & LOMB INC
Noise/vibration reduction control
InactiveUS20150100221A1Undesirable effectAnalogue computers for vehiclesSilencing apparatusInternal combustion engineControl theory
In one aspect, a system for reducing noise or vibration generated by an internal combustion engine is described. An engine controller is arranged to generate firing information suitable for operating the working chambers of the engine in a skip fire manner to deliver a desired amount of torque. A noise / vibration reduction unit is arranged to help reduce noise or vibration based on the firing information. The noise / vibration controller actively controls a device that is not a part of the engine to alter an NVH characteristic of the vehicle in a desired manner based at least in part on a skip fire characteristic.
Owner:TULA TECH INC
Transcriptional regulation of plant biomass and abiotic stress tolerance
InactiveUS20050097638A1Increase biomassImprove toleranceSugar derivativesOther foreign material introduction processesWild typeTranscriptional regulation
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including increased biomass or improved cold or other osmotic stress tolerance, as compared to wild-type or reference plants. The invention also pertains to expression systems that may be used to regulate these transcription factor polynucleotides, providing constitutive, transient, inducible and tissue-specific regulation.
Owner:MONSANTO TECH LLC +1
Apparatus and method for pumping and operating optical parametric oscillators using DFB fiber lasers
ActiveUS20070035810A1Reduce pump powerLarge and undesirable buildupLaser using scattering effectsExcitation process/apparatusInfrared laser beamLithium niobate
An optical parametric oscillator (OPO) is described that efficiently converts a near-infrared laser beam to tunable mid-infrared wavelength output. In some embodiments, the OPO includes an optical resonator containing a nonlinear crystal, such as periodically-poled lithium niobate. The OPO is pumped by a continuous-wave fiber-laser source having a low-power oscillator and a high-power amplifier, or using just a power oscillator). The fiber oscillator produces a single-frequency output defined by a distributed-feedback (DFB) structure of the fiber. The DFB-fiber-laser output is amplified to a pump level consistent with exceeding an oscillation threshold in the OPO in which only one of two generated waves (“signal” and “idler”) is resonant within the optical cavity. This pump source provides the capability to tune the DFB fiber laser by straining the fiber (using an attached piezoelectric element or by other means) that allows the OPO to be continuously tuned over substantial ranges, enabling rapid, wide continuous tuning of the OPO output frequency or frequencies.
Owner:LOCKHEED MARTIN CORP
Stent for endoluminal delivery of active principles or agents
InactiveUS20050209681A1Reduce adverse effectsMaintain good propertiesStentsBlood vesselsInsertion stentAnimal body
The present invention provides a stent for implantation at a site within a human or animal body comprising: an expandable body having an inner surface and an outer surface; and treatment agents applied to the outer surface of the expandable body, the treatment agents comprising a combination of Paclitaxel and FK506 or their derivatives or analogues.
Owner:CID CO LTD
Apparatus and method for pumping and operating optical parametric oscillators using DFB fiber lasers
ActiveUS7620077B2Reduce pump powerLarge and undesirable buildupLaser using scattering effectsExcitation process/apparatusInfrared laser beamLithium niobate
Owner:LOCKHEED MARTIN CORP
Leaf sequencing algorithm for moving targets
ActiveUS7796731B2Undesirable effectHandling using diaphragms/collimetersX-ray/gamma-ray/particle-irradiation therapySorting algorithmIntensity modulation
Owner:VARIAN MEDICAL SYST INT AG
Immunization of infants
InactiveUS6204250B1Prevent side-effectsUndesirable effectSsRNA viruses negative-senseAntibacterial agentsTarget antigenImmunogenicity
The present invention relates to methods and compositions which may be used to immunize infant mammals against a target antigen, wherein an immunogeniclly effective amount of a nuclic acid encoding a relevant epitope of a desired target antigen is administered to the infant. It is based, at least in part, on the discovery that such genetic immunization of infant mammals could give rise to effective cellular and humoral immune responses against target antigens.
Owner:MOUNT SINAI MEDICAL CENT OF THE CITY OF NEW YORK THE
Peptide pharmaceutical for oral delivery
ActiveUS20090317462A1Prevent undesirable effect of acidImproved profilePowder deliveryNervous disorderParticulatesActive agent
Acid-containing oral pharmaceutical compositions are provided wherein the pharmaceutical active agents are peptide compounds (i.e., those that include a plurality of amino acids and at least one peptide bond in their molecular structures). Certain barrier layers and / or particulate coated acid are used to reduce any adverse interactions that might otherwise occur between the acid of the compositions and other components of the composition. Use of these barrier layers and / or use of particulate coated acid is believed to promote a more simultaneous release of the components of the composition than is achieved by prior art acid-protection techniques, thus enhancing, and making more consistent, the bioavailability of the active peptide compounds.
Owner:ENTERIS BIOPHARMA
Monovalent antibody fragments useful as therapeutics
InactiveUS20050227324A1Superior pharmacokinetic attributeExtended half-lifeBacteriaAntibody mimetics/scaffoldsAntibody fragmentsChemistry
The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.
Owner:GENENTECH INC
Compositions and methods in the treatment of bone metabolic disorders
InactiveUS20070197573A1Block undesirable peripheral effectAvoid abuseBiocideAnimal repellantsDiseaseOpioid antagonist
Bone metabolic disorders are treated by administering to an individual a therapeutically effective amount of a peripheral opioid antagonist at one or more of the opioid receptors, including the various naloxone and naltrexone analogs or a pharmaceutically acceptable salt thereof. The invention is further embodied in the use of peripheral antagonists of the opioid receptors, such as the use of naltrexone and naloxone analogs, which can be opioid antagonist with peripheral selectivity at the μ opioid receptor, for the treatment of bone loss, osteoporosis, osteopenia and other bone disorders in individuals using opioid drugs, including patients using opioids for analgesia and in opioid drug-dependent individuals
Owner:AIKO BIOTECH
Motor vehicle wheel with a tire placed on a rim and sound-absorbent insert as well as method of producing a sound-absorbent insert
InactiveUS6244314B1The implementation process is simpleEasy to handleNon-inflatable tyresPneumatic tyre reinforcementsAutomotive engineering
Owner:CONTINENTAL AG
Display assembly with contrast inversion including two superposed display devices
InactiveUS6903784B1Reducing undesirable parallax effectUndesirable effectVisual indicationElectric indicationElectrical batteryDisplay device
A second device (24) is mounted on a first device (22) formed of a liquid crystal (27) display cell (26) at the front of which is arranged a first linear polarizer (40), of a liquid crystal (29) optical valve (28) at the back of which is arranged a second polarizer (44) and means (23) for controlling the valve (28) and the cell (26) from a switched state to a non switched state. When the cell (26) is switched to display a data item, by associating a first light or dark device (22) with a second absorbent or reflective polarizer (44), an inversion of the contrast in said data is obtained by switching the valve (28).
Owner:ASULAB SA
Urethane polymer compositions
ActiveUS20030232956A1Increasing ultimate cohesive strengthImprove responseAdhesive processesPolyureas/polyurethane adhesivesPolymer sciencePolyol
Owner:ROHM & HAAS CO
Plasma reactor with wide process window employing plural vhf sources
InactiveUS20080179011A1Solve insufficient capacityReduce impactElectric discharge tubesSemiconductor/solid-state device manufacturingEngineeringFrequency coupling
A plasma reactor includes an electrostatic chuck in the chamber for supporting the workpiece, a ceiling electrode facing the electrostatic chuck and an ESC electrode in the electrostatic chuck with an electrostatic clamping voltage supply coupled to the ESC electrode. The reactor further includes at least a first RF bias source of an LF or HF frequency coupled to the pedestal electrode, and first and second VHF power sources of different frequencies coupled to the same or to different ones of the electrodes. The first and second VHF power sources are of sufficiently high and sufficiently low frequencies, respectively, to produce center-high and center-low plasma distribution non-uniformities, respectively, in the chamber.
Owner:APPLIED MATERIALS INC
Microphone for a listening device having a reduced humidity coefficient
InactiveUS6937735B2Undesirable effectPiezoelectric/electrostrictive microphonesMicrophone structural associationHigh humidityEngineering
A microphone is constructed to be more tolerant to a wide range of relative humidity conditions without adversely affecting the performance of the microphone. The microphone includes a housing with a sound port for receiving sound and an electret assembly for converting the sound into an output signal. The electret assembly includes a diaphragm and a backplate. The backplate is made of at least two layers, usually polymeric layers. The first layer of material has a first hygroscopic coefficient and a second layer of material has a second hygroscopic coefficient. The first and second layers cause the backplate to bend in response to higher humidity conditions, thereby minimizing the adverse effects on microphone performance caused by characteristic changes in the diaphragm at the higher humidity conditions.
Owner:SONION NEDERLAND
Core tablet for controlled release of gliclazide after oral administration
InactiveUS6733782B1Facilitated releaseIncrease concentrationPowder deliveryMetabolism disorderControlled releaseOral medication
The invention relates to a matrix tablet for the prolonged release of gliclazide which ensures continuous and consistent release of the active ingredient after administration by the oral route, the release being insensitive to variations in the pH of the dissolution medium.
Owner:LES LAB SERVIER
Trilayer SAF with current confining layer
InactiveUS20060023376A1Electrical resistance is minimizedReduce the impactRecord information storageManufacture of flux-sensitive headsPartial oxidationInter layer
A current perpendicular to plane (CPP) GMR sensor having first and second outer pinned layers and a trilayer free layer therebetween. The free layer includes first and second outer magnetic layers, and a partially oxidized magnetic layer disposed there between. The middle partially oxidized layer is antiparallel coupled with the outer magnetic layers of the free layer by first and second coupling alyers which prevent oxygen migration from the central layer into the outer magnetic layers of the free layer. The partial oxidation of the middle layer provides a limited amount of electrical resistance at a desired location within the free layer to increase GMR.
Owner:HITACHI GLOBAL STORAGE TECH NETHERLANDS BV
Wide-band ratiometric radio frequency bridge
InactiveUS6486679B1Low costUndesirable effectResistance/reactance/impedenceAc/dc measuring bridgesRadio frequencyPhysics
A radio frequency bridge, useful for measuring complex values of an unknown impedance or associated complex reflection coefficient and VSWR value, which comprises an rf source, a novel asymmetrical bridge, a measuring device (comprising two logarithmic amplifiers, a difference amplifier and a phase detector), a computing device and a display or interface device. The complex impedance may be any two terminals of a general N-port network not to exclude an antenna with or without feed-line. The invention is more accurate than prior art when measuring complex impedance values having magnitudes from approximately five ohms to an upper value limited only by the dynamic range of the logarithmic amplifiers, normally greater than 4000 ohms. It has the great advantage of maintaining constant measuring accuracy over a wide measuring range and can be designed to operate over very wide bandwidths.
Owner:HOLT KENNETH DAVID
Periodically clearing thin film plasma processing system
An enhanced DC plasma processing system which acts to immediately stop current from flowing through the plasma allows a variety of alternative embodiments for varying applications. In one embodiment, a tapped inductor is switched to ground to achieve substantial voltage reversal of about 10% upon detection of an arc condition through voltage and / or rate of voltage change techniques. This reversal of voltage is maintained long enough to allow restoration of uniform charge density within the plasma prior to restoration of the initial driving condition. A technique for preventing arc discharges involving periodically applying a reverse voltage is effected through a timer system in the power supply.
Owner:ADVANCED ENERGY INDS
Pvd Coated Substrate
InactiveUS20080260478A1High hardnessReduce coefficient of frictionPigmenting treatmentVacuum evaporation coatingMetal alloyHardness
A PVD coating is disclosed, and in particular a nanoscale multilayer superlattice PVD coating comprising high hardness, a low friction coefficient and increased chemical inertness. The multilayer coating comprises a repeating bilayer represented by (VxMe(i-x))CyN(i-y) / (MezV(1-z))CyN(i-y) where 0.1≦x≦0.9; 0.01<y<0.99 and 0.1≦z≦0.9 and Me is a substantially pure metal or a metal alloy. The composition of the coating through the layers alternates from layer to layer according to a V-rich layer and a Me-rich layer modulated sequence. Vanadium is incorporated within the layer composition and has been found to act as a lubricating agent during sliding wear. Carbon, also incorporated within the coating, serves to further stabilise the friction coefficient thereby increasing the chemical inertness between cutting tool and workpiece material.
Owner:SHEFFIELD HALLAM UNIVERSITY
Stabilizer and reamer system having extensible blades and bearing pads and method of using same
ActiveUS20090294178A1Trimmed more efficientlyReduce lateral vibrationDrill bitsDrilling rodsEngineeringReamer
Drilling systems and methods for enlarging a borehole that include at least one expandable reamer and at least one expandable stabilizer axially spaced therefrom in a tubular string such as a drill string, the at least one expandable reamer and the at least one expandable stabilizer being independently actuatable by different-sized actuation devices. A relatively lower tool is actuatable by a smaller actuation device, such as a drop ball, which passes through a relatively higher tool in the drill string without triggering the higher tool.
Owner:BAKER HUGHES INC
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