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82 results about "Vascular proliferation" patented technology

Medical Definition: vascular proliferation. Phenomenon that involves the development of new blood vessels. It is characteristic that occurs in the most severe forms of diabetic retinopathy, where the factor that stimulates the process is ischemia resulting from alterations in the microcirculation.

Use of microbubbles with high-intensity cavitation generated by combining ultrasonic in preparation of anti-tumor neovascularization medicaments

The invention relates to use of microbubbles with high-intensity cavitation generated by combining ultrasonic in preparation of anti-tumor neovascularization medicaments. The microbubbles are high-intensity cavitation effect microbubbles generating mechanical damage under the action of pulse-type high-peak negative pressure ultrasonic energy; and the ultrasonic energy has higher peak sound pressure and lower transmitting duty cycle. The generated high-intensity cavitation effect can generate obvious tumor microcirculation blocking effect on the tumor neovascularization, repeatedly perform deprivation therapy for further generating tumor growth inhibition, and reduce the transfer rate of malignant tumors. The novel treatment use of the microbubbles is applied to the treatment of various solid malignant tumors and angiogenesis pathological changes and is brand new use of the microbubble with application prospect.
Owner:刘政 +1

Enternal administration of arginine and glutamine for abnormal vascular proliferation

The subject invention provides a method and compositions for preventing and / or treating abnormal vascular proliferation in a human infant where the method involves enterally administering arginine and glutamine to the infant in about equimolar amounts to provide a total amount of arginine and glutamine that is effective to prevent or treat the abnormal vascular proliferation. Arginyl-glutamine dipeptide was shown to be an advantageous form in which to provide the two amino acids.
Owner:MEAD JOHNSON NUTRITION +1

Tat PTD-Endostatin recombination protein, preparation method and application thereof

The present invention discloses a Tat PTD-Endostatin recombination protein, which is a fusion protein comprising a protein transduction domain of human immunodeficiency virus (HIV) transactivation transduction protein Tat and human endostatin, wherein the amino acid sequence of the protein transduction domain of the HIV transactivation transduction protein Tat is represented by SEQ ID NO.1, and the amino acid sequence of the human endostatin is represented by SEQ ID NO.2. The protein of the present invention has the following advantages that: the function of the endostatin can be maintained, wherein the function of the endostatin is that the endostatin can inhibit angiogenesis; the protein has advantages of high transduction efficiency, easy blood-brain barrier crossing, and easy blood-ocular barrier crossing; the protein can overcome the limitation of the poor membrane spanning effect of the endostatin and play the angiogenesis inhibition effect well; the protein can be used for treatments of various diseases caused by angiogenesis, including ocular vascular proliferative diseases and various tumors, such as diabetes retinopathy, non-small cell lung cancer, and the like.
Owner:SHANDONG UNIV

Treatment with anti-alpha2 integrin antibodies

The invention relates to treatment of cancer. More specifically the invention relates to methods of treating cancer selected from the group consisting of squamous cell cancer, lung cancer including small-cell lung cancer, non-small cell lung cancer, adenocarcinoma of the lung, and squamous carcinoma of the lung, cancer of the peritoneum, hepatocellular cancer, gastric or stomach cancer including gastrointestinal cancer, pancreatic cancer, glioblastoma, cervical cancer, ovarian cancer, liver cancer, bladder cancer, hepatoma, breast cancer, colon cancer, colorectal cancer, endometrial or uterine carcinoma, salivary gland carcinoma, kidney or renal cancer, liver cancer, prostate cancer, vulval cancer, thyroid cancer, hepatic carcinoma and various types of head and neck cancer, as well as B-cell lymphoma including low grade / follicular non-Hodgkin's lymphoma (NHL); small lymphocytic (SL) NHL; intermediate grade / follicular NHL; intermediate grade diffuse NHL; high grade immunoblastic NHL; high grade lymphoblastic NHL; high grade small non-cleaved cell NHL; bulky disease NHL; mantle cell lymphoma; AIDS-related lymphoma; and Waldenstrom's Macroglobulinemia; chronic lymphocytic leukemia (CLL); acute lymphoblastic leukemia (ALL); Hairy cell leukemia; chronic myeloblastic leukemia; and post-transplant lymphoproliferative disorder (PTLD), as well as abnormal vascular proliferation associated with phakomatoses, edema such as that associated with brain tumors, Meigs' syndrome, melanoma, mesothelioma, multiple myeloma, fibrosarcoma, osteosarcoma and epidermoid carcinoma, by administering antibodies directed to α2β1 integrin.
Owner:ICHNOS SCI SA

Application of compound radix salviae miltiorrhizae preparation to preparation of pulmonary arterial hypertension resisting medicaments

The invention belongs to the field of pharmaceuticals and relates to application of a compound radix salviae miltiorrhizae preparation to preparation of pulmonary arterial hypertension resisting medicaments. According to the application disclosed by the invention, monocrotaline and a low-pressure oxygen cabin are utilized for reproducing a pulmonary arterial hypertension model on a rat, treatment and administration are performed through compound radix salviae miltiorrhizae dripping pills, and experimental data indicates that the compound radix salviae miltiorrhizae can significantly reduce the pulmonary arterial hypertension of a model animal, show a good effect of resisting pulmonary arterial vascular proliferation in pathology and improve the pulmonary arterial ring relaxation of the animal with the pulmonary arterial hypertension. The compound radix salviae miltiorrhizae dripping pills can be used as an ideal medicament for preventing and treating the pulmonary arterial hypertension and other related diseases.
Owner:TIANJIN TASLY PHARMA CO LTD
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