41results about How to "Inhibition of production" patented technology

The invention discloses a class of 2,5-dihydroxyterephthalamide compounds (I) and pharmaceutically acceptable salts thereof, their preparation methods, pharmaceutical compositions and preparations for treating and / or preventing nervous system-related diseases Use in pharmaceuticals, including but not limited to vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, Glaucoma, ischemic stroke, hemorrhagic stroke, and neurological damage caused by traumatic brain injury;

Disclosed is a Tat PTD-Endostatin recombinant protein, which is a fusion protein comprising a protein transduction domain of human immunodeficiency virus transactivation transduction protein Tat and human endostatin. The amino acid sequence of the protein transduction domain of the human immunodeficiency virus transactivation transduction protein Tat is represented by SEQ ID NO.1, and the amino acid sequence of the human endostatin is represented by SEQ ID NO.2. The protein of the present invention maintains the function that the endostatin can inhibit angiogenesis, has advantages of high transduction efficiency, easy blood-brain barrier crossing, and easy blood-ocular barrier crossing, overcomes the limitation of the poor membrane spanning effect of the endostatin, can play the angiogenesis inhibition effect better, and can be used for treatment of various diseases caused by angiogenesis, comprising ocular vascular proliferative diseases and various tumors, such as diabetes induced retinopathy, non-small cell lung cancer, and the like.

The invention discloses a dehydrogenation zaluzanin C derivative and a preparation method and application thereof. The dehydrogenation zaluzanin C derivative is a compound of a structure as indicated in formula I or medically acceptable salt of the compound, tautomer, stereisomer or a precursor compound. The dehydrogenation zaluzanin C derivative is obtained by conducting chemical modification on dehydrogenation zaluzanin C. It is indicated by experiments that the dehydrogenation zaluzanin C derivative has a remarkable anti-inflammatory function, especially for acute peritonitis, is expected to be developed as an anti-inflammatory drug, especially as the anti-inflammatory drug for treating acute peritonitis and has medicinal value.