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Composition capable of promoting insulin secretion and inhibiting generation of advanced glycosylation end products

A technology for the secretion of glycated end products and insulin, which can be applied in drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., and can solve problems such as reducing the blood supply of islets

Inactive Publication Date: 2011-02-16
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pharmacological experiments have confirmed that aminoguanidine will reduce the blood supply of pancreatic islets, and at high concentrations, it will inhibit the secretion of insulin by pancreatic B cells, thus limiting its clinical application. In the screening experiment of AGEs inhibitors, aminoguanidine is only used as a positive control drug.

Method used

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  • Composition capable of promoting insulin secretion and inhibiting generation of advanced glycosylation end products
  • Composition capable of promoting insulin secretion and inhibiting generation of advanced glycosylation end products
  • Composition capable of promoting insulin secretion and inhibiting generation of advanced glycosylation end products

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Experimental program
Comparison scheme
Effect test

Embodiment 1～10

[0028] Embodiment 1~10: the ratio of various components in the composition is listed in Table 1

[0029] The ratio of various components in the composition of table 1

[0030]

Embodiment 16

[0031] Embodiment 16: The extraction process and steps of cinnamon proanthocyanidins in this embodiment are as follows:

[0032] (1) Carry out mechanical pulverization with traditional Chinese medicine cinnamon, granule passes 50 mesh sieves, obtains cinnamon coarse powder material;

[0033] (2) Take 5 g of the above-mentioned cinnamon coarse powder and carry out Soxhlet extraction with petroleum ether, after extraction at 70°C for 10 hours, take out the cinnamon powder, and evaporate the petroleum ether to dryness;

[0034] (3) Add 50 mL of distilled water to the cinnamon powder after Soxhlet extraction, heat and stir for 60 minutes, filter to remove slag, and obtain an extract; add 200 mL of ethanol to the extract, stir in an ice-water bath for 30 minutes, and then filter The white precipitate was removed, and the filtrate was distilled under reduced pressure to recover ethanol to obtain an aqueous phase extract;

[0035](4) Pass the above-mentioned aqueous phase extract th...

Embodiment 17

[0036] Embodiment 17: The extraction process and steps of cinnamon proanthocyanidins in this embodiment are as follows:

[0037] (1) Carry out mechanical pulverization with traditional Chinese medicine cinnamon, granule passes 60 mesh sieves, obtains cinnamon coarse powder material;

[0038] (2) Take 5 g of the above-mentioned cinnamon coarse powder and carry out Soxhlet extraction with petroleum ether, after extraction at 70°C for 10 hours, take out the cinnamon powder, and evaporate the petroleum ether to dryness;

[0039] (3) Add 75 mL of distilled water to the cinnamon powder after Soxhlet extraction, heat and stir for 60 minutes, filter to remove slag, and obtain an extract; add 200 mL of ethanol to the extract, stir in an ice-water bath for 60 minutes, and then filter The white precipitate was removed, and the filtrate was distilled under reduced pressure to recover ethanol to obtain an aqueous phase extract;

[0040] (4) Pass the above-mentioned aqueous phase extract t...

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Abstract

The invention relates to a composition capable of promoting insulin secretion and inhibiting generation of advanced glycosylation end products. The composition comprises the following components in percentage by mass: 5-95% of proanthocyanidin extract and 5-95% of dihydrochalcone. The main component of the proanthocyanidin extract is proanthocyanidin which accounts for 50-70% of the mass of the extract. The composition lays a foundation for the production of the future compound medicines, is beneficial to controlling blood sugar of diabetics and preventing and treating diabetic complications. The composition of the invention has the advantage that the multifunctional synergistic effect is obviously superior to effect of each independently used component.

Description

technical field [0001] The invention relates to a composition capable of promoting insulin secretion and inhibiting the formation of advanced glycation end products. Background technique [0002] Diabetes mellitus is a syndrome of glucose, protein and lipid metabolism disorder caused by lack of insulin in the body or increase of hormones that antagonize insulin, or that insulin cannot exert normal physiological functions in target cells. Diabetes and its complications such as cataract, kidney disease and cardiovascular disease seriously affect human health. Traditional oral hypoglycemic drugs have limited and single curative effect. It has become a hotspot to develop new natural sources of multi-target combination drugs for diabetes and its complications. In response to this demand, the present invention has developed insulin secretion-stimulating effects and A preparation method of a composition derived from cinnamon and golden buckwheat proanthocyanidin extracts and a com...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61K31/12A61P3/10A61P5/50
Inventor 雍克岚吕敬慈黎超汤燕金
Owner SHANGHAI UNIV
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