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Kappa-carrageenin oligose selenizing derivate, preparation method thereof and application for being used as medicine

A technology of carrageenan oligosaccharides and derivatives, applied in the field of κ-carrageenan derivatives, can solve the problems of carrageenan selenide derivatives with large molecular weight, difficulty in dissolving and absorbing, and intense reaction, etc., to achieve inhibition of tumor angiogenesis, Small molecular weight, blood sugar lowering effect

Inactive Publication Date: 2009-09-09
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcoming is: this reaction is very intense, not only has bigger potential safety hazard, but also is accompanied by the formation of toxic substances, and the carrageenan selenide derivatives generated at the same time has a large molecular weight, which is difficult to dissolve and absorb, making it clinically application is very limited

Method used

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  • Kappa-carrageenin oligose selenizing derivate, preparation method thereof and application for being used as medicine
  • Kappa-carrageenin oligose selenizing derivate, preparation method thereof and application for being used as medicine
  • Kappa-carrageenin oligose selenizing derivate, preparation method thereof and application for being used as medicine

Examples

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Effect test

example 1

[0033] Take 1 gram of κ-carrageenan and place it in 100 milliliters of 0.1% sulfuric acid, heat it in a water bath, control the temperature of the reaction solution at 40-42° C., stir and react at a constant temperature for 2 hours, and the test results are as follows: figure 1 Shown, where a: galactose; b: carrageenan; c-d results of carrageenan degradation in sulfuric acid solution for 0.5, 1, and 2 hours. Add 1 g of sodium selenite to the degraded κ-carrageenan oligosaccharide, stir at a constant temperature of 40-42° C. for 3 hours, and then cool to room temperature with water. Neutralize the sulfuric acid in the reaction product with 10% sodium hydroxide solution to make the pH value of the reaction product 7. The reaction product was distilled under reduced pressure at 50-70°C and concentrated to 1 / 10. The obtained concentrated product was placed in a petri dish, frozen at -50°C and dried to obtain a pink powder crude κ-carrageenan oligosaccharide selenide derivative. ...

example 2

[0037] Take 1 gram of κ-carrageenan and place it in 100 ml of 0.5% hydrochloric acid, heat it in a water bath, control the temperature of the reaction solution at 68-70° C., and stir for 1 hour at constant temperature. Add 5 g of sodium selenite to the degraded κ-carrageenan oligosaccharide, stir at a constant temperature of 68-70° C. for 2 hours, and then cool to room temperature with water. Use 1% sodium hydroxide solution to neutralize the hydrochloric acid in the reaction product, so that the pH value of the reaction product is 7. The reaction product was distilled under reduced pressure at 50-70°C and concentrated to 1 / 10. The obtained concentrated product was placed in a petri dish, and freeze-dried at -50° C. to obtain a crude pink powdery κ-carrageenan oligosaccharide selenide derivative. Purify the above crude product with an activated carbon column, and freeze-dry the purified product at -50°C to obtain a pink powder κ-carrageenan oligosaccharide selenide derivative...

example 3

[0039] Take 1 gram of κ-carrageenan and place it in 100 ml of 3% acetic acid, heat it in a water bath, control the temperature of the reaction solution at 60-62° C., and stir for 3 hours at a constant temperature. Add 0.2 g of sodium selenite to the degraded κ-carrageenan oligosaccharide, stir at a constant temperature of 60-62° C. for 6 hours, and then cool to room temperature with water. Neutralize the acetic acid in the reaction product with 5% sodium hydroxide solution to make the pH value of the reaction product 7. The reaction product was distilled under reduced pressure at 50-70°C and concentrated to 1 / 10. The obtained concentrated product was placed in a petri dish, and freeze-dried at -50° C. to obtain a crude pink powdery κ-carrageenan oligosaccharide selenide derivative. Purify the above crude product with an activated carbon column, and freeze-dry the purified product at -50°C to obtain a pink powder κ-carrageenan oligosaccharide selenide derivative. The average d...

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Abstract

The invention relates to a kappa-carrageenin oligose selenizing derivate which has the following composition and structure: a single component n is equal to 1 to 30, and the average molecular weight of a mixed component is 800 to 6000 Da. The main steps of the preparation method of the kappa-carrageenin oligose selenizing derivate are as following: kappa-carrageenin is placed into acid to be heated and degraded, sodium selenite is added into degraded kappa-carrageenin oligose and is stirred for 2-hours at the temperature of 40 DEG C-70 DEG C-, acid in reaction products is neutralized, the reaction products are decompressed and concentrated, the distillated product is frozen, dried and decompressed, the crude products are purified by active carbon columns, and the purified products are frozen and dried to obtain fine products. The invention has mild reacting condition, and no toxic substance is generated.

Description

technical field [0001] The invention relates to a polymer compound, especially a derivative of κ-carrageenan. Background technique [0002] Selenium is an essential element for life activities. It exists in two forms: inorganic selenium and organic selenium. The common inorganic selenium is sodium selenite and sodium selenate. Its physiological activity is low and its toxicity is high. Mutagenesis, the dose is difficult to control when used, so the application of inorganic selenium is greatly limited. Organic selenium has the characteristics of low toxicity and small side effects, and can well exert various physiological activities of selenium. Organic selenium mainly includes selenium polysaccharides, selenium amino acids, selenoproteins, and selenium nucleic acids, among which selenium polysaccharides not only have various activities of inorganic selenium, but also have various physiological functions of polysaccharides, and the activity of selenium polysaccharides is gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P35/00A61P3/10
Inventor 姚子昂吴海歌
Owner DALIAN UNIV
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