48 results about "Presenile dementia" patented technology

The present invention is (-)-meptazinol carbamate derivative as shown and / or its salt and their preparation process and use in preparing medicine for treating dementia including Alzheimer disease. The said compound, extracorporeal experiment shows, has very high AChE and BChE inhibiting activity, hundreds times higher than that of available medicine.

The present invention provides one kind of phenoxy indenone compound. Pharmacological experiment shows that the compound may be used as acetylcholinesterase inhibitor and can competitively inhibit the activity of acetylcholine, delay the hydrolysis of acetylcholine and thus raise the synapse effect of acetylcholine. The compound may be used in preparing medicine for treating presenile dementia. The present invention has easy to obtain material, has mild reaction condition, high yield, simple operation and low production cost, and is suitable for industrial production.

The invention provides a substituted phenyl pyrazolone derivative and specifically relates to a 2-phenyl-pyrazoline-3-one compound as well as a pharmaceutically-acceptable salt and solvate thereof. Atarget compound is prepared by carrying out a reflux reaction on substituted ethyl acetoacetate and benzyloxyphenylhydrazine in a sodium hydroxide aqueous solution, then, carrying out hydrogenolysis on a benzyl group under the actions of palladium / carbon and hydrogen to obtain phenylpyrazolone phenol, then, making phenylpyrazolone phenol react with bromochloroalkane to obtain a chloride, and finally, carrying out condensation on the chloride and secondary amine. The substituted phenyl pyrazolone derivative provided by the invention shows good free radial scavenging capability in vitro, has relatively strong H3 receptor inhibiting activity, shows good blood brain barrier penetration capability and has unique double activities so as to have a unique clinic effect on treating neurodegenerative diseases such as cerebral apoplexy, presenile dementia, parkinsonism and amyotrophic lateral sclerosis. The compound provided by the invention is applied to preparation of drugs for treating centralsystem related diseases and inflammatory diseases. A structure of a general formula is shown as the specification.

The invention belongs to the technical field of medicine, in particular to a preparation method of milk veteh, oleaster, walnut green husk and worm grass-containing health wine and an oxidation resistant pharmacologic activity effect thereof. The health wine comprises the following raw materials by weight percentage 50-70% of hoantchy root, 10-20% of oleaster, 10-20% of walnut green husk and 10-20% of worm grass. The method comprises the following steps of: smashing the milk veteh, the oleaster, the walnut green husk and the worm grass into powder; putting the powder into a distilling tank; adding low wine of 38-45 degree, the weight of which is 200-300 times of that of medicinal materials, into the distilling tank, and dipping for more than 72 hours; adding with royal jelly to be dissolved after filtering; sealing and storing for more than 90 days; and stirring at one time in every 10-20 days to obtain the health wine. Various external oxidation resistant activity tests prove that thehealth wine has stronger removing capability to tested free radical under the condition of a certain concentration, and has better and comprehensive oxidation resistant effect. Being drunk for a longtime, the health wine can prevent, cure or release various diseases such as heart cerebrovascular disease, cancer, diabetes mellitus, presenile dementia, and the like, and has no poison and side effects.

The invention provides a method for constituting presenile dementia bandicoot model by injecting Hcy to caudal vein, abdomen or ventriculus laterali cerebri of the bandicoot, which can induce the brain mantle and hippocampal cortex amyloid of the bandicoot to deposit to generate age pigment and lead tau undertake exceeding abnormal phosphorylation as well as appear compound symptom like academic handicap and dysmnesia, etc. The model can be used for defending presenile dementia, screening new medicines, appraising the curing effect and researching the nosogenesis.

The invention relates to a nutrition even blend oil which contains seaweed oil. The nutrition even blend oil uses plant grease such as peanut oil and flax seed oil as the material oil, uses seaweed oil as the alloyed oil, uses fat fusible tea polyphenol and vitamin E as the anti-crawl oxidant. The accession volume can be calculated according to the physiology and the nutrition need of different people and the fatty acid content of the oil; each 100 gram finished blend oil contains: SFA 12 to 18 grams, MUFA 39 to 46 grams, Omega-6 PUFA 31 to 38 grams, Omega-3 PUFA 5 to 9 grams; wherein, Omega-3 LCPUFA 0.1 to 5.0 grams, DHA:(DPA+EPA) 0.25 to 10:1, DHA:EPA 4:1 to 60:1, or DHA:DPA 2:1 to 10:1, no EPA, or HAD without DPA and EPA. The blend oil has the functions of promoting the brain growth and defending the short sight and the presenile dementia and reducing the cerebrovascular disease.

The invention discloses a production technique of fermented brown rice. The production technique comprises the following steps of (1), washing and impurity removal; (2), softening; (3), fermentation with compound bacteria; (4), high-temperature sterilization; (5), low-temperature vacuum continuous drying. The fermented brown rice obtained by the technique provided by the invention accords with the conventional whole-grain cooking and eating method of people on rice; not only is a mouth feel ameliorated, but also the contents of oligosaccharide prebiotics of xylooligosaccharide and the like and gamma-aminobutyric acid are improved. After the fermented brown rice is eaten, not only can an intestinal flora structure be ameliorated, but also diseases of constipation, hypertension, diabetes mellitus, presenile dementia and the like can be effectively prevented. By using the technique provided by the invention, total ingredients of the rice including a rice husk and a germ part can be effectively utilized; not only is the comprehensive utilization rate of a raw a material improved, but also the possibility of environmental pollution is avoided.

The invention discloses endophytic fungi from huperzia serrata. The invention is obtained through being separated from the living body of pteridophyta huperzia serrata by adopting endophytic fungi separation and purification technology, and is identified through biosystematics to be acremonium endophytium. The preservation number of the strain is CCTCC M 206118. The invention generates Huperzine A analogous compound through the strain liquid fermentation of the endophytic fungi from huperzia serrata, and is significant micro organism for searching the Huperzine A new resource of the active component for curing the presenile dementia.

The invention provides a novel herbal formulation used to improve the memory and in treatment of senile and presenile dementia as a brain tonic. Formulation(s) comprises of alcoholic extract of Tinospora cordifolia, Centella asiatica, Withania somnifera, Mucuna pruriens and Curcuma longa. The formulation can be used as an emulsion or as a soft gelatin capsule for oral dosage forms.

Disclosed are amyloid-binding compounds which are Chrysamine G derivatives, pharmaceutical compositions containing these compounds, and the use of these compounds in vivo to identify Alzheimer's disease and to diagnose other diseases characterized by amyloidosis such as The method of Down's congenital dementia. Also disclosed are pharmaceutical compositions containing Chrysamine G and its derivatives and the use of these compositions for the prevention of cell degeneration and amyloid-induced toxicity in amyloidosis-related diseases. At the same time, it also discloses a quantitative method for amyloid deposition in tissue homogenates of biological living tissues and post-mortem tissues by using the chrysamine derivatives.

The present invention relates to a compound-laughing gas synthase inhibitor. Said invention also provides its general formula and its preparation method, and also discloses the medicine containing said compound and its application for curing the diseases of septic shock, enteritis, rheumatoid arthritis, diabetes mellitus, cerebral ischemic injury and presenile dementia, etc.

The invention relates to application of a pharmaceutical composition to preparation of drugs for treating vertigo caused by vertebrobasilar insufficiency. Raw materials of the pharmaceutical composition are genuine traditional Miao herbs including rhizoma coptidis (Miao dialect: Wang Lianjing), radix hedysari (Miao dialect: Dou Xiao), rhizoma rehmanniae (Miao dialect: Fei Ta), rhizoma curcumae Longae (Miao dialect: Wo Ha) and radix scutellariae (Miao dialect: E Ga). The pharmaceutical composition is applied to the vertigo caused by stroke, stroke sequela, ischemia, hemorrhage, posthemorrhagicedema, reperfusion injury, thrombosis, vasoconstriction, infarction and presenile dementia and various reasons. In addition, animal experiments verify the therapeutic effect of the pharmaceutical composition of the invention in treating cerebrovascular or related diseases, and the pharmaceutical composition has the function of regulating body functions, thus providing another choice for patients.