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48 results about "Presenile dementia" patented technology

Scutellarein carbamate derivates, preparation method and application thereof

The invention relates to a novel scutellarin aglycon 4 (1)-position carbamate derivant (1), a preparation method and the application thereof. A pharmacological experiment proves that the compounds have obvious inhibitory activity of acetylcholinesterase and have protective effect with different degrees on PC12 cell trauma induced by H2O2, so the compounds can be used for preparing the drugs for treating neurodegenerative diseases such as vascular dementia, AD (presenile dementia), etc.
Owner:SICHUAN UNIV

Nutrition balanced mixed oil containing algal oil and producing method thereof

InactiveCN101124929AAvoid forgetting to takeComplementary scienceEdible oils/fatsFood preparationDiseaseOmega-6 PUFAs
The invention relates to a nutrition even blend oil which contains seaweed oil. The nutrition even blend oil uses plant grease such as peanut oil and flax seed oil as the material oil, uses seaweed oil as the alloyed oil, uses fat fusible tea polyphenol and vitamin E as the anti-crawl oxidant. The accession volume can be calculated according to the physiology and the nutrition need of different people and the fatty acid content of the oil; each 100 gram finished blend oil contains: SFA 12 to 18 grams, MUFA 39 to 46 grams, Omega-6 PUFA 31 to 38 grams, Omega-3 PUFA 5 to 9 grams; wherein, Omega-3 LCPUFA 0.1 to 5.0 grams, DHA:(DPA+EPA) 0.25 to 10:1, DHA:EPA 4:1 to 60:1, or DHA:DPA 2:1 to 10:1, no EPA, or HAD without DPA and EPA. The blend oil has the functions of promoting the brain growth and defending the short sight and the presenile dementia and reducing the cerebrovascular disease.
Owner:张国浩 +1

(-)-meptazinol carbamate derivative and/or its salt and their prepn and use

The present invention is (-)-meptazinol carbamate derivative as shown and / or its salt and their preparation process and use in preparing medicine for treating dementia including Alzheimer disease. The said compound, extracorporeal experiment shows, has very high AChE and BChE inhibiting activity, hundreds times higher than that of available medicine.
Owner:FUDAN UNIV

Phenoxy indenone compounds ,process for preparing same and use thereof

The present invention provides one kind of phenoxy indenone compound. Pharmacological experiment shows that the compound may be used as acetylcholinesterase inhibitor and can competitively inhibit the activity of acetylcholine, delay the hydrolysis of acetylcholine and thus raise the synapse effect of acetylcholine. The compound may be used in preparing medicine for treating presenile dementia. The present invention has easy to obtain material, has mild reaction condition, high yield, simple operation and low production cost, and is suitable for industrial production.
Owner:ZHEJIANG UNIV

Substituted phenyl pyrazolone derivative as well as preparation method and application of substituted phenyl pyrazolone derivative

The invention provides a substituted phenyl pyrazolone derivative and specifically relates to a 2-phenyl-pyrazoline-3-one compound as well as a pharmaceutically-acceptable salt and solvate thereof. Atarget compound is prepared by carrying out a reflux reaction on substituted ethyl acetoacetate and benzyloxyphenylhydrazine in a sodium hydroxide aqueous solution, then, carrying out hydrogenolysis on a benzyl group under the actions of palladium / carbon and hydrogen to obtain phenylpyrazolone phenol, then, making phenylpyrazolone phenol react with bromochloroalkane to obtain a chloride, and finally, carrying out condensation on the chloride and secondary amine. The substituted phenyl pyrazolone derivative provided by the invention shows good free radial scavenging capability in vitro, has relatively strong H3 receptor inhibiting activity, shows good blood brain barrier penetration capability and has unique double activities so as to have a unique clinic effect on treating neurodegenerative diseases such as cerebral apoplexy, presenile dementia, parkinsonism and amyotrophic lateral sclerosis. The compound provided by the invention is applied to preparation of drugs for treating centralsystem related diseases and inflammatory diseases. A structure of a general formula is shown as the specification.
Owner:ZHEJIANG UNIV +1

Milk veteh, oleaster, walnut green husk and worm grass-containing health wine and effect thereof

InactiveCN101637500AStrong elimination abilityExcellent and comprehensive antioxidant effectAlcoholic beverage preparationAntinoxious agentsDiseaseMedicinal herbs
The invention belongs to the technical field of medicine, in particular to a preparation method of milk veteh, oleaster, walnut green husk and worm grass-containing health wine and an oxidation resistant pharmacologic activity effect thereof. The health wine comprises the following raw materials by weight percentage 50-70% of hoantchy root, 10-20% of oleaster, 10-20% of walnut green husk and 10-20% of worm grass. The method comprises the following steps of: smashing the milk veteh, the oleaster, the walnut green husk and the worm grass into powder; putting the powder into a distilling tank; adding low wine of 38-45 degree, the weight of which is 200-300 times of that of medicinal materials, into the distilling tank, and dipping for more than 72 hours; adding with royal jelly to be dissolved after filtering; sealing and storing for more than 90 days; and stirring at one time in every 10-20 days to obtain the health wine. Various external oxidation resistant activity tests prove that thehealth wine has stronger removing capability to tested free radical under the condition of a certain concentration, and has better and comprehensive oxidation resistant effect. Being drunk for a longtime, the health wine can prevent, cure or release various diseases such as heart cerebrovascular disease, cancer, diabetes mellitus, presenile dementia, and the like, and has no poison and side effects.
Owner:TIANJIN UNIV OF SCI & TECH

Establishment of C578L/6 mouse animal model of transbuman senile dementia APP gene and use

InactiveCN1686567AHave a behavioral disorderIn-vivo testing preparationsMicroorganismMale pronucleus
A mouse animal model C57BL / 6 for the APP gene of human presenile dementia (AD) is disclosed, which can be used to research the AD, develop its medicine and screen its vaccine. Its configuring process includes using PDGF promoter to regulate APP and configure its transgene, injecting it in the male pronucleus of fertilized ovum of mouse, PCR, southern discrimination to obtain transgenic male animal, cesarean section, and DNA recombination-inbred-line passage for configuring its line.
Owner:INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI

Receptor signal transduction positive modulator, preparation method and purpose thereof

The invention provides a substitute five membered heterocyclic compound represented by the following formula, and salt, ester, solvate and metal composition which are all accepted by pharmacy or a prodrug having the same biological activity. The invention also provides a purpose of the compound as a glucagon-like peptide-1 receptor (GLP-1R) signal transduction positive modulator and an application for preventing and / or curing metabolic diseases (including but not being limited to type-2 diabetes, insulin resistance and adiposity, and the like), angiocardiopathy and neurodegenerative diseases (such as Alzheimer's disease, AD) also called presenile dementia, and the like.
Owner:THE NAT CENT FOR DRUG SCREENING +1

Method for constructing composite type presenile dementia animal model

InactiveCN101107924AAnimal husbandryBandicootPhosphorylation
The invention provides a method for constituting presenile dementia bandicoot model by injecting Hcy to caudal vein, abdomen or ventriculus laterali cerebri of the bandicoot, which can induce the brain mantle and hippocampal cortex amyloid of the bandicoot to deposit to generate age pigment and lead tau undertake exceeding abnormal phosphorylation as well as appear compound symptom like academic handicap and dysmnesia, etc. The model can be used for defending presenile dementia, screening new medicines, appraising the curing effect and researching the nosogenesis.
Owner:华中科技大学同济医学院

Medicinal composition used for treating or preventing cerebrovascular disease and related diseases

The invention discloses a medicinal composition used for treating or preventing cerebrovascular disease and related diseases. The composition comprises the following components in parts by weight: 1-50 parts of DHA (docosahexaenoic acid), 1-50 parts ofbreviscapine, 20-50 parts of and 1-10 parts of hirudin. The composition also comprises effective amount of human fat stem cell which is taken as a carrier for the medicinal composition, thus treatment medicine smoothly penetrates through a blood brain barrier, and the effect of targeted treatment on the cerebrovascular disease and related diseases is achieved. The medicinal composition disclosed by the invention can effectively improve diseases such as attack, infarction and embolism which are caused by ischemia of the brain, can effectively inhibit thrombus from being formed in human body and has good curative effect on senile dementia caused by the cerebrovascular disease, namely presenile dementia.
Owner:GUIZHOU MAQIKA PHARMA +1

Herbal formulation as memory enhancer in alzheimer condition

The invention provides a novel herbal formulation used to improve the memory and in treatment of senile and presenile dementia as a brain tonic. Formulation(s) comprises of alcoholic extract of Tinospora cordifolia, Centella asiatica, Withania somnifera, Mucuna pruriens and Curcuma longa. The formulation can be used as an emulsion or as a soft gelatin capsule for oral dosage forms.
Owner:COUNCIL OF SCI & IND RES

(S)-3-(1-dimethylaminoethyl)phenol preparation method

The invention relates to a preparation method of key intermediate (S)-3-(1-dimethylaminoethyl)phenol of Rivastigmin for curing presenile dementia, comprising the following steps: adopting (RS)m-benzyloxy-alpha,N-dimethyl benzylamine as raw material and L-(+)-tartaric acid as resolving agent to obtain (S)m-benzyloxy-alpha,N-dimethyl benzylamine, and finally obtaining the target product (S)-3-(1-dimethylaminoethyl)phenol in the presence of aldehyde solution and Raney nickel in alcoholic solution through aminomethylation and hydrogenation by which benzyl can be removed; meanwhile, (R)m-benzyloxy-alpha,N-dimethyl benzylamine and partial (S)m-benzyloxy-alpha,N-dimethyl benzylamine in the separated mother solution are recycled and after racemizing the recycled materials in the present of basic catalyst, (RS)m-benzyloxy-alpha,N-dimethyl benzylamine can be obtained to be used as raw material for repeatedly use and separation. The method of the invention has simple process and cheap raw materials; the separated R-enantiomer can be recycled after the racemization, and compared with the prior art, the yield is greatly improved and the cost is reduced so that the preparation method is applicable to the industrial production.
Owner:SHANGAI PHARMA GRP CO LTD

Construction method for presenile dementia white rat animal model

The present invention belongs to the field of medical evaluation and detection technology, and is especially the construction process of Alzheimer's disease (AD) rat animal model. Rat is set in lighting environment of 10-1000 Lux light strength continuously for 1-10 weeks. The model may be used in the research of AD pathogenesis in the early stage or the disease process including beta-amyloid protein increase and congregation, skelemin Tau AD like abnormality and over phosphorylation, etc., the screening of medicine for treating AD, the evaluation of AD treating method and the research of AD pathogenesis.
Owner:华中科技大学同济医学院

Production technique of fermented brown rice

The invention discloses a production technique of fermented brown rice. The production technique comprises the following steps of (1), washing and impurity removal; (2), softening; (3), fermentation with compound bacteria; (4), high-temperature sterilization; (5), low-temperature vacuum continuous drying. The fermented brown rice obtained by the technique provided by the invention accords with the conventional whole-grain cooking and eating method of people on rice; not only is a mouth feel ameliorated, but also the contents of oligosaccharide prebiotics of xylooligosaccharide and the like and gamma-aminobutyric acid are improved. After the fermented brown rice is eaten, not only can an intestinal flora structure be ameliorated, but also diseases of constipation, hypertension, diabetes mellitus, presenile dementia and the like can be effectively prevented. By using the technique provided by the invention, total ingredients of the rice including a rice husk and a germ part can be effectively utilized; not only is the comprehensive utilization rate of a raw a material improved, but also the possibility of environmental pollution is avoided.
Owner:QINGZHOU RONMER BIOLOGY TECH CO LTD

Method for acetyl choline content indirect detection by proton magnetic resonance wave spectrum analysis

The invention provides a detection method for obtaining rat sinkaline signals through Proton MR spectroscopy (<1>H MRS) and then indirectly reflecting the content of acetylcholines in a rat. The method compares the content relationship of total sinkaline and acetylcholines in a sea horse area, a striaturn area, a frontal cortex area and a somatic cortex area of the normal rat; the contents of the total sinkaline and the acetylcholines of the rat in the four brain areas have obvious relativity through double variant and linear regression analysis. As shown by the result, the rat sinkaline signals obtained through the Proton MR spectroscopy are used as the predicated value of the content of the acetylcholines in the rat, which has statistic significance. Simultaneously, loss of the acetylcholines is a very important neuropathological variation of presenile dementia, thereby the method is hopeful to be applied to noninvasive early clinical diagnosis of the presenile dementia.
Owner:HUAZHONG UNIV OF SCI & TECH

Herbal formulation as memory enhancer in Alzheimer condition

The invention provides a novel herbal formulation used to improve the memory and in treatment of senile and presenile dementia as a brain tonic. Formulation(s) comprises of alcoholic extract of Tinospora cordifolia, Centella asiatica, Withania somnifera, Mucuna pruriens and Curcuma longa. The formulation can be used as an emulsion or as a soft gelatin capsule for oral dosage forms.
Owner:COUNCIL OF SCI & IND RES

Health-caring, low cholesterol egg with antioxidant, presenile dementia preventing functions

The invention discloses a health egg which is oxidation resistant, preventing and curing the senile dementia, born by poultry nursed with feed stuff added with curcuma longa; adding curcuma longa of 5-1000mg per basic feed stuff for poultry or curcuma longa slag of 5-300g, with the nursing time for at least 8 days, and the curcuma longa can be added in the long run. The invention makes the function of curcuma longa and polarity egg be combined together, which makes the action of oxidation resistance and prevention and cure of the senile dementia stronger. The invention employs biological transformation technique, employs poultry laying egg as carrier, to transform the effect component in the curcuma longa into eggs through the biological enrichment function of poultry, and to realize purpose of being oxidation resistant, and preventing and curing the senile dementia.
Owner:湖南福湘生物技术有限公司

Compound for antemortem diagnosis of alzheimer's disease and i(IN VIVO) imaging and prevention of amyloid deposition

InactiveCN1285818AOrganic active ingredientsNervous disorderIn vivoAmyloid degeneration
Disclosed are amyloid-binding compounds which are Chrysamine G derivatives, pharmaceutical compositions containing these compounds, and the use of these compounds in vivo to identify Alzheimer's disease and to diagnose other diseases characterized by amyloidosis such as The method of Down's congenital dementia. Also disclosed are pharmaceutical compositions containing Chrysamine G and its derivatives and the use of these compositions for the prevention of cell degeneration and amyloid-induced toxicity in amyloidosis-related diseases. At the same time, it also discloses a quantitative method for amyloid deposition in tissue homogenates of biological living tissues and post-mortem tissues by using the chrysamine derivatives.
Owner:UNIVERSITY OF PITTSBURGH

Medicine for treating alzheimer's disease

InactiveCN101120946AReduce the number of age spotsReduced tau protein levelsOrganic active ingredientsNervous disorderEvodiamineActive component
The present invention provides a medicine for presenile dementia treatment, which takes dehydrogenation evodiamine as the active component. Studies proves that the dehydrogenation evodiamine has an inhibiting effect in notable pathological change of presenile dementia patients, which can not only reduce the senile plaque quantity of the presenile dementia, but also can reduce the phosphorylation tau protein level, therefore learning and memory impairment are dramatically improved. The medicine is an effective medicine for presenile dementia prevention and treatment.
Owner:HUAZHONG UNIV OF SCI & TECH

Traditional Chinese medicine decoction for preventing and treating presenile dementia

The invention discloses traditional Chinese medicine decoction for preventing and treating presenile dementia. The traditional Chinese medicine decoction is prepared from the following traditional Chinese medicinal materials in parts by weight: 20 parts of prepared rehmannia root, 15 parts of rhizome of acorus calamus, 10 parts of radix polygoni multiflori, 25 parts of the root of red-rooted salvia, 10 parts of szechuan lovage rhizome, 12 parts of dried mature seeds of corylus avellana, 18 parts of dried mature fruit of citrullus colocynthis, 8 parts of forest frog's oviduct, 15 parts of Mongolian snakegourd root, 8 parts of Chinese thorowax root, 8 parts of oyster, 18 parts of fructus chebulae immaturus, 12 parts of all-grass of digitaria sanguinalis, 8 parts of astragalus membranaceus, 12 parts of mature coconut fruit, 5 parts of tobacco, 5 parts of sapium baccatum, 6 parts of seeds and roots of wild sword bean and 6 parts of aizoon stonecrop herb. Clinical experiment results show that the remarkable efficacy of preventing and treating presenile dementia is realized by selecting proper medicinal materials according to the ratio, and high safety and no toxic or side effects are realized.
Owner:虞志秋

Medication for treating senilism dementia and preparing technique

InactiveCN1795855AExcellent learning and memory function improvementImprove medicinal effectOrganic active ingredientsNervous disorderWestern medicineDihydropyridine
A medicine for treating presenile dementia is just the HA-T1 which is the huperzine A derivative N-methyl-1,4-dihydropyridine-3-formate or the HA-T2 which is the huperzine A derivative N-methyl-1,2,5,6-tetrahydropyridine-3-formate. Its preparing process is also disclosed.
Owner:杨兴斌

Indolylpiperidine compound and preparation process and use thereof

InactiveCN1317276CNervous disorderOrganic chemistryCholinesteraseIndolylpiperidine
The present invention provides a kind of indoxyl piperidine compound. The pharmacological tests show that said kind of compound can be used as inhibitor of acetylcholin esterase, can competitively inhibit the activity of acetylcholin esterase, can delay hydrolysis of acetylcholin so as to raise the action of acetylcholin in synapsis and attain the goal of curing presenile dementia.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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