32 results about "Venous malformation" patented technology

The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and / or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.

The invention relates to an implant for blood vessels, in particular for influencing the blood flow in the region of arteriovenous malformations, having a wall made of individual filaments combined toform a braided edge, said braided edge in an insertion catheter takes on an elongated shape having a reduced diameter and at the implant site expands while adapting to the vessel diameter and increasing the braiding density.

Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.

The present invention comprises compositions and methods for forming an endovascular occlusion to treat conditions such as aneurysms, arterio-venous malformations, excessive blood supply to tumors, massive vascular hemorrhaging, and other conditions which require an embolization to alleviate the condition. Embodiments of the present invention comprise compositions and methods that use calcium alginate, without or without endovascular coils or similar devices, to form occlusions at a site within the mammalian body targeted for occlusion.

Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a vein. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the vein.

The invention discloses application of lauromacrogol combined hyaluronic acid in preparation of a medicine for treating venous malformed foam sclerosis. The lauromacrogol combined hyaluronic acid is prepared to form a foam hardening agent in particular application. The preparation method of lauromacrogol combined hyaluronic acid comprises the following steps: pumping lauromacrogol, hyaluronic acid and injection water by using an injector, and uniformly shaking and mixing; pumping sterile air by the other injector, wherein the two injectors are connected by a medical tee-joint valve; and feeding a plurality of times in a Tessari method, and mixing to form uniform and stable foam. According to the application, the foam hardening agent is prepared from the lauromacrogol combined hyaluronic acid and used for treating venous malformation, so that the half time of foam can be remarkably prolonged, and the curative effect can be improved. Currently, the method is successfully adopted in the stomatological department of Qilu Hospital of Shandong University, 20 cases with large-area venous malformation in maxillofacial region are treated, and the clinical effect is remarkable.

The invention discloses an in-vitro experimental model used for observing a venous malformation filling state and an experimental method. The in-vitro experimental model comprises a liquid storage device; the bottom of the liquid storage device is communicated with a liquid flowing pipe I; the lower part of the liquid flowing pipe I is provided with a bulge; the lower part of the bulge is communicated with a fluid flowing pipe II; the fluid flowing pipe II is provided with a flow rate control switch; a camera is arranged above the bulge; an opening is formed at one side portion of the bulge; and the opening is sealed by a sealing component. The experimental model of the present invention has the advantages of structural simplicity and simplicity in simulation experimental operation. With the experimental model adopted, the condition and treatment result of a venous malformation can be simulated more authentically. With the experimental method of the invention adopted, blood flowing and the treatment condition of a bubble hardening therapy at the venous malformation can be simulated, and a theoretical basis can be provided for the realization of the treatment of the venous malformation.

The invention discloses a developing foam hardening agent for treating venous malformations. The developing foam hardening agent comprises two effective ingredients, namely, polycinnamyl alcohol and ultravist, in a volume ratio of 2:1. A preparation method of the developing foam hardening agent specifically comprises the following steps of: extracting the polycinnamyl alcohol and the ultravist using by using a syringe according to a formula ratio, shaking and mixing up uniformly, extracting sterile air by using another syringe, connecting the two syringes by using a medicinal three-way valve, and injecting front and back for multiple times according to a Tessari method so as to mix the polycinnamyl alcohol and the ultravist into uniform and stable foams, wherein the volume ratio of the polycinnamyl alcohol to the sterile air is 1:4. According to the preparation method, a hardening agent, namely, a polycinnamyl alcohol injection, and a contrast agent, namely, the ultravist, are mixed up according to appropriate ratio and prepared into a foam hardening agent, the foam hardening agent is more stable when being compared with a hardening agent which is prepared from polycinnamyl alcohol and air merely, and the foam hardening agent is injected into venous malformation lesion in a partial puncture mode under the mediation of DSA (Digital Subtraction Angiography), so that precision, visualization and idealization in a curative effect are achieved.

The invention relates to a human brain arteriovenous malformation biomechanics model and an in vitro establishing method thereof. The system comprises a power pump, a gas replacement device, a pressure sensor, a malformation vascular model, a normal bran microvascular model and a liquid storage bottle which are connected in sequence and form a blood feeding artery model circulation loop, wherein the malformation vascular model and the normal bran microvascular model are arranged in parallel. The invention provides the human brain arteriovenous malformation biomechanics model and the in vitro establishing method thereof, which are used for developing research on brain blood vessel fluid dynamics, cytobiology and a vessel malformation mechanism.

The present disclosure relates to the field of endovascular treatment. More particularly, the present invention is a tool designed to implement an endovascular treatment by the implementation of two or more lumens on a microcatheter and / or having a side hole in a single lumen. The present invention ameliorates the medical difficulty associated with making a good plug to prevent reflux of liquid embolic along catheter and maximize distal penetration, usually in treatment of arteriovenous malformations (AVM) and arteriovenous fistulas (AVF).