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32 results about "Venous malformation" patented technology

Venous malformation is a subtype of vascular malformation affecting the venous vasculature. They are usually congenital and can be treated by Sclerotherapy or Laser Therapy.

Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implantation

Methods and apparatus for treating or preventing endoleaks after an endovascular graft (e.g., a stent, tubular graft, stent-graft, coated stent, covered stent, intravascular flow modifier or other endovascular implant that affects, limits or prevents blood flow into a vascular defect such as an aneurysm, arterio-venous fistula, arterio-venous malformation, vessel wall perforation, etc.) has been implanted in the vasculature of a human or veterinary patient. An expansile polymeric material, such as a swellable polymer (e.g., a hydrogel), a flexible or elastomeric polymer foam (e.g. silicone, polyurethane, etc.) or a carrier member (e.g, a coil, filament, wire, etc) that carries a quantity of such expansile polymer is delivered into a perigraft space (i.e., space between the endovascular graft and the surrounding blood vessel wall) such that the polymeric material expands in situ to substantially fill the perigraft space or a portion thereof. The expansile polymeric material is delivered into he perigraft space through a catheter and / or cannula that is placed prior to, during or after the implantation of the endovascular graft. The invention includes an injector apparatus that is useable to deliver the expansile polymeric material through the wall of a previously implanted graft. After delivery into the perigraft space, the expanded polymeric material expands so as to fill all or an intended portion of the perigraft space in a manner that substantially prevents additional blood from leaking or flowing into such perigraft space. One type of blood-absorbing, porous, expansile polymeric material useable in this invention is a super-expansile hydrogel.
Owner:MICROVENTION INC

Compositions and methods using microspheres and non-ionic contrast agents

The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and / or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
Owner:BIOSPHERE MEDICAL SA (FR)

Compositions and methods for improved occlusion of vascular defects

InactiveUS20050133046A1Great therapeutic effectivenessRisk minimizationSurgical adhesivesDiagnosticsAbnormal tissue growthEndovascular occlusion
The present invention comprises compositions and methods for forming an endovascular occlusion to treat conditions such as aneurysms, arterio-venous malformations, excessive blood supply to tumors, massive vascular hemorrhaging, and other conditions which require an embolization to alleviate the condition. Embodiments of the present invention comprise compositions and methods that use calcium alginate, without or without endovascular coils or similar devices, to form occlusions at a site within the mammalian body targeted for occlusion.
Owner:RGT UNIV OF MICHIGAN

Systems and methods for treating superficial venous malformations like spider veins

Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a vein. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the vein.
Owner:GREEN MEDICAL

Implant for influencing blood flow

The invention relates to an implant for blood vessels, in particular for influencing the blood flow in the region of arteriovenous malformations, having a wall made of individual filaments combined toform a braided edge, said braided edge in an insertion catheter takes on an elongated shape having a reduced diameter and at the implant site expands while adapting to the vessel diameter and increasing the braiding density.
Owner:PHENOX

Application of lauromacrogol combined hyaluronic acid in preparation of medicine for treating venous malformed foam sclerosis

The invention discloses application of lauromacrogol combined hyaluronic acid in preparation of a medicine for treating venous malformed foam sclerosis. The lauromacrogol combined hyaluronic acid is prepared to form a foam hardening agent in particular application. The preparation method of lauromacrogol combined hyaluronic acid comprises the following steps: pumping lauromacrogol, hyaluronic acid and injection water by using an injector, and uniformly shaking and mixing; pumping sterile air by the other injector, wherein the two injectors are connected by a medical tee-joint valve; and feeding a plurality of times in a Tessari method, and mixing to form uniform and stable foam. According to the application, the foam hardening agent is prepared from the lauromacrogol combined hyaluronic acid and used for treating venous malformation, so that the half time of foam can be remarkably prolonged, and the curative effect can be improved. Currently, the method is successfully adopted in the stomatological department of Qilu Hospital of Shandong University, 20 cases with large-area venous malformation in maxillofacial region are treated, and the clinical effect is remarkable.
Owner:SHANDONG UNIV QILU HOSPITAL

Implant for influencing the blood flow in arteriovenous defects

The invention relates to an implant (1) for blood vessels, in particular for influencing the blood flow in the area of arteriovenous defects, with a wall made up of individual filaments (2), which are brought together to form a substantially tubular mesh that extends in an axial direction from a proximal end to a distal end, wherein the individual filaments (2) cross one another and form intersections (3) with one another, wherein the implant (1) is deformable in such a way that, in an insertion catheter, it adopts a shape with a reduced diameter and, at the site of implantation, expands to adapt to the diameter of the blood vessel, wherein the filament ends are in each case brought together at least in pairs at the proximal and / or distal end of the mesh and are permanently interconnected, wherein the interconnected filament ends are shaped to be atraumatic,; and wherein the filaments (2) crossing one another at the intersections (3) lying distally from the filament ends are connected directly or indirectly to one another at the proximal end (10) of the implant (1). This ensures that the implant (1), after release, also expands at the proximal end as far as the vessel walls, and the filament ends do not protrude into the vessel lumen.
Owner:PHENOX

Implant for influencing blood flow

An implant for blood vessels, in particular to influence the flow of blood in the area of arteriovenous malformations. The implant has a wall comprising individual filaments combined so as to form a circular braiding, the circular braiding being positioned in elongated form and with a reduced diameter in an insertion catheter and expanding at the placement site thus adapting to the vessel diameter and increasing its braiding density.
Owner:PHENOX

Compositions and methods for improved occlusion of vascular defects

The present invention comprises compositions and methods for forming an endovascular occlusion to treat conditions such as aneurysms, arterio-venous malformations, excessive blood supply to tumors, massive vascular hemorrhaging, and other conditions which require an embolization to alleviate the condition. Embodiments of the present invention comprise compositions and methods that use calcium alginate, without or without endovascular coils or similar devices, to form occlusions at a site within the mammalian body targeted for occlusion.
Owner:RGT UNIV OF MICHIGAN

Fumed silica embolic compositions

This invention is directed to compositions for embolizing vascular sites. The compositions described herein comprise fumed silica as a rheological modifier. The fumed silica imparts high viscosity to the compositions under static conditions but allows the compositions to flow readily under shear conditions. This invention is also directed to methods for treatment of aneurysms, arteriovenous fistulae, arteriovenous malformations, tumors, and other vascular diseases using the compositions described herein. Other uses are disclosed as well. Kits of parts including those compositions and devices which can deliver these composition are also described.
Owner:MICRO THEREPEUTICS INC

Developing foam hardening agent for treating venous malformations and preparation method thereof

The invention discloses a developing foam hardening agent for treating venous malformations. The developing foam hardening agent comprises two effective ingredients, namely, polycinnamyl alcohol and ultravist, in a volume ratio of 2:1. A preparation method of the developing foam hardening agent specifically comprises the following steps of: extracting the polycinnamyl alcohol and the ultravist using by using a syringe according to a formula ratio, shaking and mixing up uniformly, extracting sterile air by using another syringe, connecting the two syringes by using a medicinal three-way valve, and injecting front and back for multiple times according to a Tessari method so as to mix the polycinnamyl alcohol and the ultravist into uniform and stable foams, wherein the volume ratio of the polycinnamyl alcohol to the sterile air is 1:4. According to the preparation method, a hardening agent, namely, a polycinnamyl alcohol injection, and a contrast agent, namely, the ultravist, are mixed up according to appropriate ratio and prepared into a foam hardening agent, the foam hardening agent is more stable when being compared with a hardening agent which is prepared from polycinnamyl alcohol and air merely, and the foam hardening agent is injected into venous malformation lesion in a partial puncture mode under the mediation of DSA (Digital Subtraction Angiography), so that precision, visualization and idealization in a curative effect are achieved.
Owner:SHANDONG UNIV QILU HOSPITAL

Human brain arteriovenous malformation biomechanics model and in vitro establishing method thereof

The invention relates to a human brain arteriovenous malformation biomechanics model and an in vitro establishing method thereof. The system comprises a power pump, a gas replacement device, a pressure sensor, a malformation vascular model, a normal bran microvascular model and a liquid storage bottle which are connected in sequence and form a blood feeding artery model circulation loop, wherein the malformation vascular model and the normal bran microvascular model are arranged in parallel. The invention provides the human brain arteriovenous malformation biomechanics model and the in vitro establishing method thereof, which are used for developing research on brain blood vessel fluid dynamics, cytobiology and a vessel malformation mechanism.
Owner:GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY

Kit for mutation detection of pathogenic gene POU3F4 of inner-ear malformation/incomplete separation type-III cochlear malformation

The invention discloses a kit for mutation detection of a pathogenic gene POU3F4 of inner-ear malformation / incomplete separation type-III cochlear malformation. The kit comprises a reagent for extracting DNA from a sample to be detected, a PCR reaction reagent for amplifying the DNA of the sample, and a reagent for sequencing a PCR amplification product. The PCR reaction reagent for amplifying theDNA of the sample comprises a PCR primer. The kit is used for detecting whether or not mutation of the POU3F4 gene c.255_297del43 happens to a patient so as to diagnose the cause of the occurrence ofinner-ear malformation / incomplete separation type-III cochlear malformation. The kit is beneficial to clinical implementation of POU3F4 mutation screening work on patients suffering from inner-ear malformation / incomplete separation type-III cochlear malformation and provides a basis for the diagnosis of the patients suffering from inner-ear malformation / incomplete separation type-III cochlear malformation.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Dual lumen microcatheter

The present disclosure relates to the field of endovascular treatment. More particularly, the present invention is a tool designed to implement an endovascular treatment by the implementation of two or more lumens on a microcatheter and / or having a side hole in a single lumen. The present invention ameliorates the medical difficulty associated with making a good plug to prevent reflux of liquid embolic along catheter and maximize distal penetration, usually in treatment of arteriovenous malformations (AVM) and arteriovenous fistulas (AVF).
Owner:WALZMAN DANIEL EZRA

Array-based method for detection of copy number variations in the HLA locus for the genetic determination of susceptibility of development of venous malformations in the extracranial segments of the cerebrospinal veins and kit thereof

Method for in vitro diagnosis of susceptiblility of developing venous malformations i the extracranial segment of the cerebrospinal veins in a patient comprising the detection of copy number variations (CNVs) in chromosome 6p21 in a sample of genomic DNA of the patient, wherein the venous malformations are associated with the development of multiple sclerosis.
Owner:LONDON EQUITABLE & ITS CAPACITY TRUSTEE OF THE THINK TANK TRUST

Application of hyaluronic acid combined with lauromacrogol in preparation of foam sclerosing medicine for treating venous malformation

The invention discloses application of lauromacrogol combined hyaluronic acid in preparation of a medicine for treating venous malformed foam sclerosis. The lauromacrogol combined hyaluronic acid is prepared to form a foam hardening agent in particular application. The preparation method of lauromacrogol combined hyaluronic acid comprises the following steps: pumping lauromacrogol, hyaluronic acid and injection water by using an injector, and uniformly shaking and mixing; pumping sterile air by the other injector, wherein the two injectors are connected by a medical tee-joint valve; and feeding a plurality of times in a Tessari method, and mixing to form uniform and stable foam. According to the application, the foam hardening agent is prepared from the lauromacrogol combined hyaluronic acid and used for treating venous malformation, so that the half time of foam can be remarkably prolonged, and the curative effect can be improved. Currently, the method is successfully adopted in the stomatological department of Qilu Hospital of Shandong University, 20 cases with large-area venous malformation in maxillofacial region are treated, and the clinical effect is remarkable.
Owner:SHANDONG UNIV QILU HOSPITAL

Compositions and methods for improved occlusion of vascular defects

InactiveCN1893987AReduce potential spilloverSurgical adhesivesTissue regenerationEndovascular occlusionArteriovenous malformation
The present invention comprises compositions and methods for forming an endovascular occlusion to treat conditions such as aneurysms, arterio-venous malformations, excessive blood supply to tumors, massive vascular hemorrhaging, and other conditions which require an embolization to alleviate the condition. Embodiments of the present invention comprise compositions and methods that use calcium alginate, without or without endovascular coils or similar devices, to form occlusions at a site within the mammalian body targeted for occlusion.
Owner:RGT UNIV OF MICHIGAN

Jugular vein compressor

The invention relates to a jugular vein compressor. The jugular vein compressor comprises a neck support plate, a saccule and an air charging device, wherein the neck support plate is used for surrounding the neck; the saccule comprises a first saccule and a second saccule, wherein the first saccule and the second saccule are arranged on the inner side of the neck support plate in a spacing mannerto compress jugular vein; the air charging system is connected with the first saccule and the second saccule and used for inflating the inner part of the first saccule and the inner part of the second saccule; and the air charging device is used for inflating the inner part of the first saccule and / or the inner part of the second saccule, so that the saccules can compress the jugular vein one side or two sides, the pressure of the jugular vein can be increased, jugular vein malformation and artery and vein malformation are full, ideal measurement images can be obtained, and the surgical success rate is increased. The jugular vein compressor is simple in structure, and in the compression process, the compression strength can be maintained consistent.
Owner:GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER

Non-invasive detection method for venous malformation and related syndromes

The invention provides a non-invasive detection method for venous malformation and related syndromes. The non-invasive detection method at least comprises the following steps: providing sequencing data of venous malformation related genes in free DNA (Deoxyribose Nucleic Acid) of plasma of a detected object, wherein the vein malformation related gene is selected from one or more of TEK, PIK3CA, AKT1, MTOR and PTEN; and comparing the sequencing data with a reference sequence to obtain mutations related to vein malformation and related syndromes. Free DNA liquid biopsy is used for replacing tissue biopsy, a series of complications caused by tissue biopsy are avoided, non-invasion is achieved, operation is safe, materials are convenient to take, side effects are small, and materials can be taken repeatedly. The method can be widely applied to mutation detection of people suffering from vein malformation and related syndromes, a perfect vein malformation biological sample library is constructed, and original data support is provided for clinical and biological research.
Owner:臻和(北京)生物科技有限公司

Cell mixture and preparation method and application thereof

The invention belongs to the technical field of laboratory animals, and relates to a cell mixture and a preparation method and application thereof, especially, to an application of a mixture of adipose-derived stem cells (ADSCs) and immortalized human umbilical vein endothelial cells to preparation of a preparation for interfering and establishing a vascular malformation animal model. The mixture of adipose-derived stem cells (ADSCs) and immortalized human umbilical vein endothelial cells is used for interfering and establishing a vascular malformation animal model. The result shows that the vascular malformation animal model can be obtained at low cost, in a short period, and with high efficiency; and the established vascular malformation animal model of a nude mouse is obviously visible in vascular malformation and makes a significant practical sense in researching pathogenesis of vascular malformation and screening of clinical medicine treatment.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Developing foam hardening agent for treating venous malformations and preparation method thereof

The invention discloses a developing foam hardening agent for treating venous malformations. The developing foam hardening agent comprises two effective ingredients, namely, polycinnamyl alcohol and ultravist, in a volume ratio of 2:1. A preparation method of the developing foam hardening agent specifically comprises the following steps of: extracting the polycinnamyl alcohol and the ultravist using by using a syringe according to a formula ratio, shaking and mixing up uniformly, extracting sterile air by using another syringe, connecting the two syringes by using a medicinal three-way valve, and injecting front and back for multiple times according to a Tessari method so as to mix the polycinnamyl alcohol and the ultravist into uniform and stable foams, wherein the volume ratio of the polycinnamyl alcohol to the sterile air is 1:4. According to the preparation method, a hardening agent, namely, a polycinnamyl alcohol injection, and a contrast agent, namely, the ultravist, are mixed up according to appropriate ratio and prepared into a foam hardening agent, the foam hardening agent is more stable when being compared with a hardening agent which is prepared from polycinnamyl alcohol and air merely, and the foam hardening agent is injected into venous malformation lesion in a partial puncture mode under the mediation of DSA (Digital Subtraction Angiography), so that precision, visualization and idealization in a curative effect are achieved.
Owner:SHANDONG UNIV QILU HOSPITAL

Complexing agent for treating vessel malformation as well as preparation method and application of complexing agent

The invention provides a complexing agent for treating vascular malformation and a preparation method and application thereof, and belongs to the technical field of medicines. The complexing agent is composed of a fibrous protein adhesive and a pingyangmycin complexing agent, and the pingyangmycin complexing agent comprises pingyangmycin freeze-dried powder, sapponin freeze-dried powder and dexamethasone. Compared with the prior art, the complexing agent disclosed by the invention has the beneficial effects that the complexing agent for treating the vascular malformation is a sustained-release preparation formed by combining pingyangmycin, sapponin and a fibrin adhesive, is safe and effective in treatment of the vascular malformation, and has a better treatment effect; and particularly, the traditional Chinese medicine has a better effect on vein malformation, lymphatic vessel malformation and arteriovenous malformation.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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