Application of hyaluronic acid combined with lauromacrogol in preparation of foam sclerosing medicine for treating venous malformation

Abstract

The invention discloses application of lauromacrogol combined hyaluronic acid in preparation of a medicine for treating venous malformed foam sclerosis. The lauromacrogol combined hyaluronic acid is prepared to form a foam hardening agent in particular application. The preparation method of lauromacrogol combined hyaluronic acid comprises the following steps: pumping lauromacrogol, hyaluronic acid and injection water by using an injector, and uniformly shaking and mixing; pumping sterile air by the other injector, wherein the two injectors are connected by a medical tee-joint valve; and feeding a plurality of times in a Tessari method, and mixing to form uniform and stable foam. According to the application, the foam hardening agent is prepared from the lauromacrogol combined hyaluronic acid and used for treating venous malformation, so that the half time of foam can be remarkably prolonged, and the curative effect can be improved. Currently, the method is successfully adopted in the stomatological department of Qilu Hospital of Shandong University, 20 cases with large-area venous malformation in maxillofacial region are treated, and the clinical effect is remarkable.

Description

technical field [0001] The invention relates to the application of hyaluronic acid combined with lauromacrogol in the preparation of foam sclerosing medicine for treating venous malformation. Background technique [0002] Venous malformation is a congenital developmental malformation with an incidence rate of about 1:5000-10000, about 40% of which occur in the head and neck. It not only affects the face, but also causes pain, ulcers, bleeding or compression and invades adjacent tissue structures, followed by Affect language swallowing and breathing function, and even have the risk of suffocation death. [0003] Pathologically, venous malformations are composed of dilated veins of different sizes. The lesions grow in proportion to the body, develop gradually throughout life, and will not subside by themselves. Treatment options include laser, sclerotherapy, and surgery. Sclerotherapy is to inject chemical drugs into the lumen of the deformed vein to occlude the deformed vei...

AI Technical Summary

Problems solved by technology

At present, the drugs that can be used to prepare foam sclerosing agents at home and abroad are mainly sodium morrhuate and lauromacrogol. The liquid sclerosing agent is prepared into a foam according to the Tessari method and air at a ratio of 1:4. The half-life of the foam is about 120 seconds. Clinical findings Limited use in the treatment of venous malformations

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