The invention provides a novel nanometer lipid carrier containing a taxol substance for injection and a method for preparing the same. Mixed lipids are used as materials; liquid lipid and
solid lipid with different physical states are mixed according to the proportion of between 0 and 100 percent to obtain the nanometer lipid carrier (NLC) which is prepared by a mixed
solid-liquid substrate and has different crystalline states; and
microemulsion (ME) prepared by a full liquid substrate and
solid lipid nanoparticles (SLC) prepared by a full
solid substrate are also obtained. The new nanometer lipid carrier can increase or improve the encapsulation efficiency and the release property of
drug and has the characteristics of high
drug-loading amount, good stability and
low toxicity. The taxol substance, a
carrier material, a surfactant and injection water are respectively stirred to form two phases of oil and water; the
oil phase and the water phase are mixed and emulsified to obtain primary
emulsion; further taxol substance nanometer lipid carrier injection or suspension type injection which meets the requirement of intravenous injection is prepared by a high-pressure homogenization process; or a protective agent is added into the injection to prepare solid
powder for injection by vacuum
freeze drying or
spray drying; before use, normal
saline, a glucose solution or a Ringer solution is used for
dilution; and the solid
powder can be rapidly dissolved. Experiments show that the prepared nanometer lipid carrier containing the taxol substance for injection can improve targeting property to
tumor cells, improve
curative effect, greatly reduce toxic and side effects, has simple preparation process and low cost and is suitable for large-scaled industrialized production.