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Developing foam hardening agent for treating venous malformations and preparation method thereof

A foam sclerosant and venous malformation technology, applied in the field of foam sclerosant, can solve problems such as contrast agent replacement, incomplete treatment, and complex lesion structure, and achieve the effects of increasing stability, ensuring therapeutic effect, and ensuring the effect of imaging

Inactive Publication Date: 2014-09-10
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex structure of the lesion, this method cannot guarantee that the contrast agent is completely replaced by the foam sclerosing agent, and there may be incomplete treatment or the foam overflows the lesion cavity and enters the normal blood circulation to form a gas embolus, resulting in life-threatening complications such as pulmonary embolism. disease

Method used

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  • Developing foam hardening agent for treating venous malformations and preparation method thereof
  • Developing foam hardening agent for treating venous malformations and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] A developing foam sclerosing agent for treating venous malformation, the active ingredients of which include lauromacrogol and Uvesin, and the volume ratio of the two is 2:1.

[0019] The preparation method of described developing foam hardening agent, concrete steps are:

[0020] Use one syringe to extract the lauromacrogol and Uvitamin in the formula ratio, shake and mix evenly, use another syringe to extract sterile air, connect the two syringes through a medical three-way valve, inject 20 times before and after according to the Tessari method and mix to become uniform , Stable foam; wherein, the volume ratio of lauromacrogol to sterile air is 1:4.

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Abstract

The invention discloses a developing foam hardening agent for treating venous malformations. The developing foam hardening agent comprises two effective ingredients, namely, polycinnamyl alcohol and ultravist, in a volume ratio of 2:1. A preparation method of the developing foam hardening agent specifically comprises the following steps of: extracting the polycinnamyl alcohol and the ultravist using by using a syringe according to a formula ratio, shaking and mixing up uniformly, extracting sterile air by using another syringe, connecting the two syringes by using a medicinal three-way valve, and injecting front and back for multiple times according to a Tessari method so as to mix the polycinnamyl alcohol and the ultravist into uniform and stable foams, wherein the volume ratio of the polycinnamyl alcohol to the sterile air is 1:4. According to the preparation method, a hardening agent, namely, a polycinnamyl alcohol injection, and a contrast agent, namely, the ultravist, are mixed up according to appropriate ratio and prepared into a foam hardening agent, the foam hardening agent is more stable when being compared with a hardening agent which is prepared from polycinnamyl alcohol and air merely, and the foam hardening agent is injected into venous malformation lesion in a partial puncture mode under the mediation of DSA (Digital Subtraction Angiography), so that precision, visualization and idealization in a curative effect are achieved.

Description

technical field [0001] The invention relates to a foam sclerosant, in particular to a developing foam sclerosant for treating venous malformations and a preparation method thereof. Background technique [0002] In 1993, Cabrera pioneered the use of foam sclerosing agent to treat venous malformation, and the effect was remarkable, which opened up a new method for the treatment of venous malformation. The incidence of venous malformation in the head and neck is about 40%. Due to the special anatomical location, it is difficult to completely remove it by surgical methods. Foam sclerotherapy is simple, convenient, less expensive, less painful for patients, less risky, and has remarkable curative effect. It is now the first choice for the treatment of head and neck venous malformations. [0003] A variety of imaging methods, including color Doppler ultrasound and digital subtraction angiography (DSA), have been applied to foam sclerotherapy, that is, the visual treatment of veno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00
Inventor 陈安威刘少华李凯刘怡然
Owner SHANDONG UNIV QILU HOSPITAL
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