The invention relates to a functionalized modified
polyvinyl alcohol embolic
microsphere and a preparation method thereof, and belongs to the field of medical
intervention treatment. The functionalized modified
polyvinyl alcohol embolic
microsphere is prepared by taking
polyvinyl alcohol as a base material, taking amino / hydroxyl
carboxylic acid derivatives /
sulfonic acid derivatives capable of crosslinking after
acylation as a modifying agent and performing modification. The modified
microsphere prepared by the method has perfect sphere shape,
uniform size, high suspending property and
shape change elasticity of the polyvinyl
alcohol microsphere before modification. Meanwhile, a polycarboxylic / mucopolysacchariden functional group with negative charges is introduced and can be combined with micromolecular anti-tumor medicines with positive charges, so that the microsphere has high
medicine loading property. Compared with the
polyvinyl chloride microsphere which is not functionalized and cannot carry medicines or the microsphere which only introduces
single group with negative charges and has low
medicine carrying quantity in the prior art, the microsphere increases the
medicine carrying quantity and improves the
controlled release capability greatly.