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Embolism material composition as well as preparation method and use thereof

A technology of material composition and embolization, which is applied in the direction of drug combination, pharmaceutical formulation, X-ray contrast agent preparation, etc., and can solve problems such as inability to use patients

Active Publication Date: 2014-02-05
HYGEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage of MRI is that it cannot be used in patients with electrically, magnetically and mechanically active implants in the body (such as pacemakers, neurostimulators, cochlear implants or metal prosthetic eyes, etc.)

Method used

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  • Embolism material composition as well as preparation method and use thereof
  • Embolism material composition as well as preparation method and use thereof
  • Embolism material composition as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Example 1 Preparation of Polyvinyl Alcohol Embolization Microcapsules

[0085] 1) Weigh 1g of polyvinyl alcohol and prepare a 0.008g / ml polyvinyl alcohol solution;

[0086] 2) Mix 6.5g iodized oil, 5g iron ferric oxide nanoparticles and 1.5g paclitaxel evenly, then add them to the polyvinyl alcohol solution obtained in step 1), and stir to make an oil-in-water (o / w) emulsion;

[0087] 3) Weigh 3.0g of sodium sulfate and prepare a 0.21g / ml sodium sulfate solution, and add the sodium sulfate solution to step 2 at a water bath temperature 5-15°C lower than the cloud point temperature of the polyvinyl alcohol solution under this condition ) to the obtained emulsion, continue to stir and slowly raise the temperature, when the temperature rises to the cloud point temperature, add 11g formaldehyde and 5.8g sulfuric acid, solidify at constant temperature for 20h, let stand to separate layers, pour out the supernatant, filter and wash to get Polyvinyl alcohol embolization mic...

Embodiment 2

[0088] Example 2 Preparation of Polyvinyl Alcohol Embolization Microspheres

[0089] 1) Weigh 0.31g of sodium chloride, prepare a 0.025g / ml sodium chloride aqueous solution, dissolve 1g of polyvinyl alcohol in the sodium chloride aqueous solution, and obtain a solution with a polyvinyl alcohol concentration of 0.08g / ml;

[0090] 2) Disperse 2g of ferric oxide nanoparticles and 6g of paclitaxel in 8g of iodized oil to obtain a mixed solution, then add the mixed solution to the polyvinyl alcohol solution in step 1) at room temperature and stir to make a water-in-packet Oil (o / w) type emulsion;

[0091] 3) Pour the emulsion prepared in step 2) into 60g of liquid paraffin containing 2.5g of Span 85 to make an oil-in-water-in-oil type (o / w / o) double emulsion, and then add 0.6g of glutaraldehyde and 0.5 g of sulfuric acid was solidified for 2 hours at a stirring speed of 300 rpm and a water bath temperature of 35° C., filtered and washed to obtain polyvinyl alcohol embolization m...

Embodiment 3

[0092] Example 3 Preparation of gelatin embolization microcapsules

[0093] 1) Weigh 1g of gelatin, swell the gelatin with distilled water to make a 0.03g / ml gelatin solution;

[0094] 2) Disperse 0.5g of sorafenib and 3g of ferric oxide in 3.5g of iodized oil to obtain a mixed solution, and add the obtained mixed solution to the gelatin solution in step 1) in a water bath at 40°C, Stir to make an oil-in-water (o / w) emulsion, then add dropwise 0.1g / ml acetic acid solution to adjust the pH value of the emulsion to 3.5-4.1, observe the formation of microcapsules under a microscope, add distilled water to dilute, and obtain microcapsules Capsule suspension;

[0095] 3) Add 1.5g of formaldehyde to the microcapsule suspension obtained in step 2) and stir for 2 minutes in an ice-water bath, add dropwise 0.1g / ml sodium hydroxide solution, adjust the pH value to 8-9, solidify for 15 hours, and let stand to separate layer, decanting the supernatant, filtering and washing to obtain ...

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Abstract

The invention provides an embolism material composition as well as preparation method and use thereof, the embolism material composition is prepared from reactant raw materials, wherein the reactant raw materials comprise a biocompatibility material, a roentgenopaque substance and a magnetic resonance imaging substance, the roentgenopaque substance and the magnetic resonance imaging (MRI) substance are covered by the biocompatibility material. The embolism material composition not only can be directly detected by an X-ray image device, but also can be directly detected by the MRI, so that a doctor can select a detection method according to self condition of a patient and the medical device condition.

Description

technical field [0001] The invention belongs to the field of interventional medicine, and in particular relates to an embolic material composition, a preparation method and application thereof. Background technique [0002] Interventional embolization therapy refers to the introduction of embolic agents into the human body through precision instruments such as special guide wires and catheters for local treatment under the guidance of medical imaging equipment. Embolization therapy has achieved good results in the treatment of uterine fibroids, liver cancer, kidney cancer, hemangioma, vascular malformation and hemostasis, and has become an alternative to partial surgical treatment. [0003] Currently clinically used embolic agents, such as polyvinyl alcohol irregular particles or microspheres, gelatin sponge irregular particles or microspheres, etc., cannot be detected by X-ray imaging equipment (including digital Subtraction Angiography, DSA) and computed tomography (Compu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/18A61L31/16A61L31/04A61L31/06A61K49/12A61K49/04A61P35/00
Inventor 范田园卢晓静孟文静
Owner HYGEA MEDICAL TECH CO LTD
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