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Pharmaceutical composition for treating embolism and preparation method thereof

A composition and drug technology, applied in the field of interventional medicine, can solve the problems of limiting the therapeutic effect of tumor vascular malformation, poor curative effect of vascular malformation, and systemic toxic and side effects, so as to prolong the local drug action time, reduce systemic drug concentration, and reduce toxic and side effects Effect

Active Publication Date: 2010-03-17
HYGEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short retention time of the drug solution of bleomycin or pingyangmycin in the embolized area, its therapeutic effect on tumors and vascular malformations is limited, especially the rapid diffusion of the drug will also cause systemic toxic side effects
In addition, the curative effect on vascular malformations with faster blood flow is worse, so multiple administrations are required for larger lesions, which increases the suffering of patients

Method used

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  • Pharmaceutical composition for treating embolism and preparation method thereof
  • Pharmaceutical composition for treating embolism and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of microsphere

[0030] a. Preparation of blank microspheres

[0031] Using the reverse-phase suspension polymerization method, add 50ml of liquid paraffin and an appropriate amount of Span80 in a three-necked flask, nitrogen, and then dissolve polyvinyl alcohol, acrylic acid, N', N'-methylenebisacrylamide (crosslinking agent) 12.5ml of a solution of potassium persulfate (initiator) was added dropwise to the oil phase at 55°C. After pre-crosslinking for 10 minutes, tetramethylethylenediamine (catalyst) was added, and after stirring at 500rpm for 4 hours, the separation Take out the microspheres, wash them, sieve out different specifications according to the particle size, and collect the microspheres in each particle size range.

[0032] b. Preparation of drug-loaded microspheres

[0033] Take 0.10ml of wet microspheres, absorb the surface moisture, place in 12mg / ml pingyangmycin solution, soak at 4°C for 2 hours, wash off the unexchanged...

Embodiment 2

[0034] Example 2: Characterization of microspheres

[0035] a. Morphology and water absorption characteristics of microspheres

[0036] The morphology of the microspheres was observed with an optical microscope and the particle size was measured. The microspheres were freeze-dried, and then the water absorption and swelling rates of the microspheres were investigated. The water absorption rate of the microsphere refers to the ratio of the mass difference before and after water absorption to the mass of the microsphere before water absorption, and the swelling rate is the ratio of the particle size difference before and after swelling to the particle size of the microsphere before swelling. Calculated as follows:

[0037] Water absorption = (mass of microspheres after water absorption - mass of microspheres before water absorption) / mass of microspheres before water absorption

[0038] Swelling ratio = (particle size of microspheres after swelling - particle size of microsph...

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Abstract

The invention provides a pharmaceutical composition for treating embolism and a preparation method thereof, the pharmaceutical composition comprises a hydroxyl-contained biocompatible polymer materialand a monomer containing unsaturated double bonds and anion groups, as well as a polymer generated by polymerization reaction of an optional vinyl monomer, wherein the polymerization is initiated through free radicles, and bleomycin or pingyangmycin is combined on the anion groups of the generated polymer. The preparation method combines the bleomycin or the pingyangmycin on a carrier of the polymer, thereby being capable of fully playing the dual effects of an anti-tumor antibiotic and a hardening agent owned by the bleomycin or the pingyangmycin during the embolism treatment. The anion partof the polymer can be properly combined with the bleomycin or the pingyangmycin which is rich in amino groups, thereby not only realizing the higher drug loading, but also leading the drug in an emboliaztion agent to be exchanged by cation in human body, and further realizing the slow release. In addition, the embolic carrier of the polymer has the advantages of simple prepration technology andlow cost, thereby being applicable to large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of interventional medicine, and relates to a pharmaceutical composition for embolism therapy and a preparation method thereof, in particular to a pharmaceutical composition containing bleomycin or pingyangmycin for embolism therapy and a preparation method thereof . Background technique [0002] Interventional embolization therapy is a minimally invasive treatment method using modern high-tech means. It refers to the introduction of embolic agents into the human body through special precision instruments such as catheters and guide wires for local treatment under the guidance of medical imaging equipment. Embolization therapy has a good effect in the treatment of hemangioma, liver cancer, uterine fibroids, breast cancer, arteriovenous malformation and hemostasis, and has become an alternative therapy for some surgical treatments. [0003] Combining embolization therapy with anticancer drug chemotherapy to treat tumor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/14A61K47/48A61P35/00A61P9/00A61K49/04A61L31/04A61L31/16A61K47/58
Inventor 范田园袁惠燕
Owner HYGEA MEDICAL TECH CO LTD
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