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Composite coating cardiovascular medicaments elution stent and preparation thereof

A composite coating and stent-eluting technology, applied in stents, coatings, medical sciences, etc., can solve the problem that the anti-proliferation performance of stents needs to be improved, the stability of heparin on the surface of stents is not ideal, and thrombosis cannot be obtained. Progress and other issues to achieve the effect of promoting adhesion and growth, excellent mechanical properties, and inhibiting excessive proliferation

Active Publication Date: 2008-09-17
ESSEN TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the currently used drug-eluting stents have achieved excellent results in preventing hyperplasia, such drug-eluting stents still have not made great progress in preventing thrombosis
In order to prevent thrombosis, U.S. Patent No. 4,613,665 first loads a coupling agent on the surface of the metal stent, and then loads heparin on the surface of the stent through ionic bonds. performance, but the stability of heparin on the surface of the stent is not ideal, the incidence of thrombosis is still high, and the anti-proliferation performance of the stent needs to be improved; US Patent No. 5,112,457 uses plasma technology to deposit a layer of N-hexylpyrrolidone on the surface of the stent The anti-thrombotic performance of the stent is greatly improved by grafting heparin on the surface of the membrane, but the patent provides that the fabrication method is complicated, and the anti-proliferation performance of the stent needs to be further improved

Method used

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  • Composite coating cardiovascular medicaments elution stent and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The first step: prepare the bottom solution according to the following formula

[0038] Polyurethane (Biospan, U.S. Polymer Technology Group company) (15% solid content, dimethylacetamide solvent) 10 grams

[0039] N,N-Dimethylacetamide 90g

[0040] Heparin 1.0g

[0041] Polyisocyanate (Desmodur N3400, Bayer Company) 0.8 g

[0042] The second step: prepare the surface layer solution according to the following formula

[0043] PLA (Mn=120000) 2.2 grams

[0044] Tetrahydrofuran (chromatographic grade) 250 grams

[0045] Paclitaxel (purity>99.5%) 0.4g

[0046] Step 3: Make the Stand

[0047] Ultrasonic cleaning the magnesium alloy stent with isopropanol for 5 minutes, blowing and drying at 50°C for 20 minutes, after drying, use the method of spraying or dipping to make the bottom layer solution evenly and completely cover the surface of the alloy stent, and then dry at 30°C for 50 minutes Minutes, after the completion of drying at 60 ° C for 2 hours, after drying, s...

Embodiment 2

[0049] The first step: prepare the bottom solution according to the following formula

[0050] Polyurethane aqueous emulsion (NeoRez-972, Zeneca Resins company) 10 grams

[0051] water 90g

[0052] Heparin 3 grams

[0053] The second step: prepare the surface layer solution according to the following formula

[0054] PLA (Mn=130000) 5.5 grams

[0055] Tetrahydrofuran (chromatographic grade) 270 grams

[0056] Rapamycin (purity>95%) 1.65g

[0057] Step 3: Make the Stand

[0058] Clean the cobalt-chromium alloy stent ultrasonically with isopropanol for 5 minutes, then wash it with deionized purified water for 5 minutes, and dry it with air at 50°C for 20 minutes. After drying, use the method of spraying or dipping to make the underlying solution even and complete coverage On the surface of the alloy stent, dry at 30°C for 50 minutes after completion, and blow dry at 60°C for 2 hours after completion. After drying, use the method of spraying or dipping to make the surface s...

Embodiment 3

[0060] The first step: prepare the bottom solution according to the following formula

[0061] Polyurethane aqueous emulsion (Sancure 1601, Lubrizol company) 10 grams

[0062] water 90g

[0063] Heparin 3 grams

[0064] The second step: prepare the surface layer solution according to the following formula

[0065] Polylactic acid-glycolic acid copolymer (PLGA, Mn=130000, LA / GA=80 / 20) 3.5 grams

[0066] Tetrahydrofuran (chromatographic grade) 250 grams

[0067] Rapamycin (purity>99.5%) 1.1g

[0068] Step 3: Make the Stand

[0069] Clean the cobalt-chromium alloy stent ultrasonically with isopropanol for 5 minutes, then wash it with deionized purified water for 5 minutes, and dry it with air at 50°C for 20 minutes. After drying, use the method of spraying or dipping to make the underlying solution even and complete coverage On the surface of the alloy stent, dry at 30°C for 50 minutes after completion, and blow dry at 60°C for 2 hours after completion. After drying, use th...

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Abstract

The invention provides a blood vessel drug elution bracket with coating layers and the preparation method. The blood vessel drug elution bracket with coating layers comprises: a: a bare stents with supporting role; b: a non-degradation bioactive coating coated on the surface of the bare stents; and c: a degradation bioactive drug coating coated on the surface of the bioactive coating. The blood vessel drug elution bracket with coating layers has the advantages of not only obvious anti-restenosis properties, but also ability to decrease the occurrence of thrombus for the stable bioactive coating; simultaneously, the bioactive coating can intensify the adsorption force of the drug coating on the bracket surface, reduce the crack, upwrap and shedding during the using process of the drug coating, thus improving the effectiveness and safety of the drug bracket.

Description

technical field [0001] The invention relates to a composite-coated cardiovascular drug-eluting stent and a preparation method thereof, in particular to a novel composite drug-coated stent capable of simultaneously inhibiting the occurrence of restenosis and promoting the healing of damaged vessel walls to prevent thrombus formation and a preparation method thereof. Background technique [0002] Tubular atherosclerotic heart disease is one of the important causes of cardiovascular disease death and a common disease that seriously threatens human life and health. At present, percutaneous coronary angioplasty (Percutaneous transluminal coronary angioplasty, PTCA) has become one of the common methods for clinical treatment of coronary heart disease. Compared with traditional surgical techniques, interventional therapy has the advantages of less trauma, safety, high success rate, and quick recovery. However, the biggest drawback of this technique is the restenosis and thrombosis...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/10A61L31/16A61F2/82
Inventor 魏彦
Owner ESSEN TECH (BEIJING) CO LTD
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