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67 results about "Blood stem cell" patented technology
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Blood stem cells are also known as haematopoietic stem cells. Like other stem cells, they can self-renew, or copy themselves. They also produce the different types of specialized cells found in the blood: both red blood cells and the many kinds of white blood cells needed by the body’s immune system.
Method for establishing hematopoietic stem cells bank by extracting hematopoietic cells from placenta tissues
InactiveCN1407088AIncrease the number ofSave livesMammal material medical ingredientsBlood/immune system cellsHigh concentrationHematopoietic cell
A process for extracting hemopoietic stem cells from the placenta of healthy puerperant to create hemopoistic stem cell bank features that the mechanical, enzyme digestive and monoclonal antibody-magnetic bead method is used to extract blood stem cells from placenta, and concentrate and purify them. Its advantages are high activity and high concentration.
Owner:上海厚东生物科技有限公司
Apparatus for differentiating blood cells using back-scatter
InactiveUS6869569B2Material thermal conductivityMaterial analysis by electric/magnetic meansPhotodetectorRed blood cell
Blood cells of interest are readily distinguishable from other blood cells and look-a-like particles found in a blood sample by their back-scatter signature. A preferred method for differentiating platelets in a blood sample is to irradiate the cells and particles, one at a time, with a beam of radiation, and to detect back-scattered (reflected) radiation using a plurality of optical fibers to transmit the back-scattered radiation to a high-gain photodetector, e.g. a photomultiplier tube. Preferably, the back-scatter signal so obtained is combined with a second signal representing, for example, either the level of forward-scatter within a prescribed, relatively narrow angular range, or the level of side-scattered radiation, or the level of attenuation of the cell-irradiating beam caused by the presence of the irradiated cell or particle in the beam, or the electrical impedance of the irradiated cell or particle, to differentiate the cells of interest. The method and apparatus of the invention are particularly useful in differentiating platelets and basophils in a blood sample.
Owner:COULTER INTERNATIONAL CORPORATION
Method and composition for treating diabetes
InactiveUS20080075700A1Efficient repairTreated conditionBiocidePeptide/protein ingredientsDiabetes mellitusRepair tissue
The present invention is directed to the expansion, preferably TVEMF-expansion, of mammalian blood stem cells in a rotating bioreactor, preferably a TVEMF-bioreactor, to compositions resulting from the expanded and TVEMF-expanded cells, and to a method of treating disease or repairing tissue with the compositions.
Owner:REGENETECH INC
Cd34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer
Novel adeno-associated virus (AAV) isolates in nucleotide and amino acid forms and uses thereof are provided. The isolates show tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Discrete modified portions of the cap gene, VP1, VP2, and VP3, may be used alone or in combination in the present methods.
Owner:CITY OF HOPE
Recombinant adeno-associated vectors for targeted treatment
Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery.
Owner:CITY OF HOPE
Efficient induced pluripotent stem cell reprogramming method for blood cells
PendingCN108085299ASample source is convenientAccumulation of genetic mutations is lowBlood/immune system cellsArtificially induced pluripotent cellsProgenitorRed blood cell
The invention belongs to the field of cells and in particular relates to an efficient induced pluripotent stem cell reprogramming method for blood cells. The method comprises the following steps: S1,extracting monocyte from a blood specimen, and performing selective culture with an amplification culture medium so as to obtain erythrocyte progenitor cells; S2, introducing a free carrier with at least one potentiality determinant factor into the obtained erythrocyte progenitor cells; S3, culturing the erythrocyte progenitor cells with the free carrier by using a pluripotent stem cell inductionculture medium, and performing induction in a feeding layer free system so as to obtain reprogrammed intermediate state cells; S4, after induction is completed, replacing the pluripotent stem cell induction culture medium in the step S3 by a pluripotent stem cell culture medium to maintain culture, thereby obtaining cells that potentiality determinant factor expression is vanished and expression of endogenous pluripotent genes POU5F1, NANOG, TRA-1-60 and TRA-1-81 is activated, namely the induced pluripotent stem cells. The method has the beneficial effects that pluripotent stem cells without endogenous gene components can be efficiently induced, and the method is applicable to preclinical study and clinical application.
Owner:安徽中盛溯源生物科技有限公司
Method and composition for repairing heart tissue
A method of expanding blood stem cells for the repair of heart tissue and / or function, and compositions resulting from the expansion method in a rotating bioreactor. This invention also relates to a method of TVEMF-expanding blood stem cells for the repair of heart tissue and / or function, and compositions resulting from the TVEMF-expansion in the TVEMF-bioreactor.
Owner:REGENETECH INC
Reprogramming Blood Cells to Pluripotent and Multipotent Stem Cells
The present invention is based on the seminal discovery that cord blood (CB) and adult bone marrow (BM) CD34+ cells can be reprogrammed to early stem cells. The invention provides the reprogramming of CB and adult bone marrow (BM) CD34+ cells from subjects without any pre-treatment. Provided are methods for reprogramming blood cells of a subject. Also provided are methods of disease modeling and methods of generating subject-specific differentiated cells. In addition, the invention provides methods of identifying an agent that alters a function of subject-specific differentiated cells as well as isolated pluripotent or multipotent stem cells reprogrammed from blood cells.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Method and composition for repairing heart tissue
The present invention is directed to the TVEMF-expansion of mammalian blood stem cells, preferably CD34+ / CD38− cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating heart disease or repairing heart tissue with the compositions.
Owner:REGENETECH INC
Apparatus and methods for amplification of blood stem cell numbers
InactiveUS20070160582A1Increase the number ofBioreactor/fermenter combinationsBiological substance pretreatmentsBlood stem cellHematopoietic stem cell
The present invention provides an apparatus and methods for expansion of hematopoietic stem cell numbers. The stem cells are cultured and differentiated cells and endogenous growth factors are removed (depleted), permitting long term culture and expansion of the stem cells. The hematopoietic stem cells are used in numerous therapeutic procedures.
Owner:INSCEPTION BIOSCI
Reagent for stabilization of blood sample cells
ActiveCN104381245AAvoid gatheringDoes not affect molecular analysisPreparing sample for investigationDead animal preservationDipyridamoleAdenosine
The invention discloses a reagent for stabilization of blood sample cells. The reagent comprises 100 micromoles per liter of L beta-cyclodextrin, 100 micromoles per liter of disodium cromoglycate, 0.05% of potassium dichromate, 50 micromoles per liter of triflusal, 100 micromoles per liter of Terutroban, 11 millimoles per liter of sodium citrate, 1.5 millimoles per liter of theophylline, 20 micromoles per liter of dipyridamole, 0.37 millimoles per liter of adenosine, 20 millimoles per liter of glucose and 1.25 millimoles per liter of LPEG. The reagent can stabilize blood cells for at least 36h and prevent blood cell aggregation. Through the reagent, a blood sample subjected to treatment does not influence follow-up sample molecule analysis. The reagent can be widely used for blood sample molecule analysis and detection and is especially suitable for cell or molecular detection such as a microfluidic technology with strict sample cell requirements and an analysis technology platforms such as a flow cytometer with strict sample cell requirements.
Owner:广东国盛医学科技有限公司 +1
Human erythroid progenitor cell line comprising HPV E6/E7 operably linked to an inducible promoter and method for producing human enucleated red blood cells
ActiveUS8975072B2Efficient and stable productionEfficiently induce differentiationVectorsGenetically modified cellsCulture cellGenomic DNA
Owner:RIKEN
Method and means for producing tissues and tissues obtained
InactiveUS20120027740A1Reduce cell proliferationReduces or avoids possible graft versus hostBiocideNervous disorderProgenitorWhite blood cell
A method regenerates specific tissue, preferably mesenchymal tissues like bone, fat, tendon, muscle, cartilage and marrow stroma and hematological tissue (RBC, WBC, platelets, lymphocytes, hematological stem cells (HSC), endothelial progenitor cells (EPC) etc.). A method for reconstructing, regenerating, rejuvenating or reinforcing a damaged or diseased tissue in a mammal subject, and preferably a human patient, uses a (regenerated) tissue obtained by this method.
Owner:PHILIPPART PIERRE
Apparatus and methods for amplification of blood stem cell numbers
InactiveUS7795024B2Increase the number ofBioreactor/fermenter combinationsBiological substance pretreatmentsBlood stem cellHematopoietic stem cell
The present invention provides an apparatus and methods for expansion of hematopoietic stem cell numbers. The stem cells are cultured and differentiated cells and endogenous growth factors are removed (depleted), permitting long term culture and expansion of the stem cells. The hematopoietic stem cells are used in numerous therapeutic procedures.
Owner:INSCEPTION BIOSCI
Elective collection and banking of autologous peripheral blood stem cells
InactiveUS20060233768A1Effective protectionBiocideGenetic material ingredientsDiseaseCryopreservation
An elective healthcare insurance model using an individual's own peripheral blood stem cells for the individual's future healthcare uses. An individual can elect to have his or her own stem cells collected, processed and preserved, while he or she is in healthy or “pre-disease” state, for future distribution for his or her healthcare needs. The process includes methods of collection, processing, preservation and distribution of adult (including pediatric) peripheral blood stem cells during non-diseased state. The stem cells collected will contain adequate dosage amounts, for one or more transplantations immediately when needed by the individual for future healthcare treatments. The collected adult or non-neonate child peripheral blood stem cells can be aliquoted into defined dosage fractions before cryopreservation so that cells can be withdrawn from storage without the necessity of thawing all of the collected cells.
Owner:NEOSTEM
Method for the Collection And Distribution of Cord Blood Stem Cells
InactiveUS20080189045A1Increase the number ofData processing applicationsComputer-assisted medical data acquisitionCord blood stem cellUmbilical Cord Blood Stem Cell
The present invention provides a method for the collection and distribution of cord blood stem cells, particularly in order to increase the number of usable cord blood stem cells that are collected overall. By using a single collection and distribution entity that applies a uniform protocol to obtain cord blood stem cell samples at each of a plurality of different collection facilities, a greater number of samples for both private and public cord blood stem cell banks can be obtained.
Owner:CBR SYST
Method and composition for treating diabetes
The present invention is directed to the TVEMF-expansion of mammalian blood stem cells, preferably CD34+ / CD38− cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating disease or repairing tissue with the compositions.
Owner:REGENETECH INC
Apparatus for measuring blood cells and immunity from whole blood
InactiveUS20140341779A1Stay focusedBiological material analysisBiological particle analysisRed blood cellBlood stem cell
A diluted cleaning solution is contacted with the inner wall surface of an immunity measuring cell every time an immunity measurement treatment of a specimen is performed. Therefore, a diluting liquid is injected in advance, then a cleaning solution is injected, whereby a diluted cleaning solution is produced in the immunity measuring cell. As a result, the inner wall surface of the immunity measuring cell is maintained in a preferable state and the interval of the routine cleanings can be prolonged.
Owner:HORIBA LTD
Hematopoietic stem cell proliferation promoter
The present inventors discovered that the administration of an agonistic minibody (VB22B sc(Fv)2) against the TPO receptor resulted in not only the induction of human megakaryocyte-specific differentiation (increase in platelet precursor cells), but also the engraftment of transplanted hematopoietic stem cells derived from human cord blood (CD34-positive cells) and significant increase in multi-lineage hematopoietic precursor cells. TPO and TPO receptor agonists can be used as agents for promoting the growth of CD34-positive hematopoietic cells or agents for promoting the engraftment of transplanted cells in the bone marrow, which can be effective when administered alone (without using G-CSF and erythropoietin in combination) after hematopoietic stem cell transplantation (in particular, cord blood transplantation). Furthermore, TPO and TPO receptor agonists can be used as agents for promoting the growth and / or differentiation of multilineage hematopoietic precursor cells and agents for promoting the recovery of multilineage hematopoiesis.
Owner:CHUGAI PHARMA CO LTD
Adenovirus vector
ActiveUS20050176129A1Improve efficiencyImprove compatibilityGenetically modified cellsFermentationPluripotential stem cellHematopoietic cell
This invention relates to an adenovirus vector having excellent gene transfection activity on specific cell lines, particularly on hematopoietic cells. This adenovirus vector derives from the adenovirus type 35 genome by at least partial or total deletion of the E1 region therefrom. The adenovirus vector according to this invention has excellent gene transfection activity on specific cell lines, particularly on hematopoietic cells, ES cells, pluripotent stem cells, blood stem cells, and tissue stem cells.
Owner:FUSO PHARMA INDS +3
Method and composition for restoration of age-related tissue loss in the face or selected areas of the body
InactiveUS20120189585A1Restoring age-related tissue lossPromote repairBiocideCosmetic preparationsMesenchymal stem cellHyaluronic acid
This application relates to stem cell compositions and methods for restoring age-related tissue loss in the face and other selected areas of the body. In a first embodiment, a composition includes stem cells and hyaluronic acid as a carrier wherein the stem cells are peripheral blood stem cells, bone marrow-derived blood stem cells, or mesenchymal stem cells.
Owner:NEOSTEM
Diagnosis of anemia and optimizing treatment for heart repair
InactiveUS20060046268A1Good curative effectIncrease vascularizationDisease diagnosisBiological testingHeart repairCell Surface Proteins
A method of diagnosis of anemia is disclosed whereby blood is withdrawn from a patient and the level of hematopoietic stem cells (HSC) in the blood are determined by detecting a cell surface protein chosen from ACE+, CD34+, CD38, CD90+ (thyl) and Lin−. Patients with low levels of HSC are treated and in particular patients whose levels have been reduced by drugs such as ACE inhibitors are treated using an intermittent treatment regimine of the invention.
Owner:AUSTRALIAN STEM CELL CENT
Apparatus for measuring blood cells and immunity from whole blood
In conventional apparatuses for measuring blood cells and immunity from whole blood, CRP cell is used for the final cleaning of a nozzle, and CRP measurement - cleaning of CRP cell - final cleaning of nozzle are performed in this order in the CRP cell. In contrast, in the present invention, an exclusive cleaning chamber A for immunity measurement is further provided for cleaning nozzle 36 after completion of dispensing the specimen and the reagent(s) for CRP measurement to CRP cell. Thus, a configuration is adapted wherein the outer surface and inner surface of the nozzle 36 are cleaned in the cleaning chamber A for immunity measurement while the immunity measurement is performed in CRP cell 19. Since the final cleaning of nozzle 36 is performed in parallel with the CRP measurement, the time conventionally necessary for the final cleaning of the nozzle can be shortened.
Owner:HORIBA LTD
Blood cell analyzer and blood cell analyzing method
ActiveUS9778178B2Scattering properties measurementsBiological particle analysisFlow cellWhite blood cell
Owner:SYSMEX CORP
Blood stem cell collecting device
InactiveCN108624492AAvoid wastingGuaranteed utilizationBioreactor/fermenter combinationsBiological substance pretreatmentsDrive wheelCoupling
Owner:李大鹏
Method for cultivating human umbilical blood stem cell and directionally differentiating the same to dopaminergic nerve cell and application for the obtained dopaminergic nerve cell
The present invention relates to method for human navel blood stem cell cultivation and directional differentiation to dopaminergic nerve cell, the dopaminergic nerve cell and its uses. The method comprises the following steps: a) navel chord blood stem cell culture; separating navel chord blood single-nucleus cell, then inoculating it at porous plate with cover glass, culturing at culture box of 36.5-37.5 degree, 3-8% CO2, saturated humidity, the cultured navel blood stem cell being obtained. b) dopaminergic nerve cell induction and differentiation : taking navel blood stem cell of good growth state, changing liquid when the stem cell grows for12-16 days and about 70-90% cell fuse, inducing cell with conditioned medium inductor or growth factor inductor, so dopaminergic nerve cell being obtained. The present invention can provides large dopaminergic nerve cell differentiated from navel chord blood stem cell.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Method and composition for restoration of age-related tissue loss in the face or selected areas of the body
InactiveCN102625689ACosmetic preparationsOrganic active ingredientsMesenchymal stem cellHyaluronic acid
This application relates to stem cell compositions and methods for restoring age-related tissue loss in the face and other selected areas of the body. In a first embodiment, a composition includes stem cells and hyaluronic acid as a carrier wherein the stem cells are peripheral blood stem cells, bone marrow-derived blood stem cells, or mesenchymal stem cells.
Owner:NEOSTEM
Method and composition for repairing heart tissue
InactiveCN101166541APeptide/protein ingredientsMammal material medical ingredientsRepair heartHeart disease
The present invention is directed to the TVEMF-expansion of mammalian blood stem cells, preferably CD34+ / CD38- cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating heart disease or repairing heart tissue with the compositions.
Owner:REGENETECH INC
Chinese medicinal composition for inducing generation of peripheral blood stem cells and Chinese medicinal extract of Chinese medicinal composition
ActiveCN102335401ATo achieve the purpose of hematopoietic functionUnknown materialsBlood disorderMedicinal herbsCinnamon Bark
The invention relates to a Chinese medicinal composition for inducing the generation of peripheral blood stem cells and a Chinese medicinal extract of the Chinese medicinal composition. The Chinese medicinal composition comprises medicinal materials in the specification, such as cinnamon bark, red paeony root, liquoric root, dried ginger, red date, Chinese angelica, astragalus and the like.
Owner:李政育
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