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118 results about "Liver lipid" patented technology

Lipids are derived from two main sources, exogenously from food and endogenously made in the liver. Lipids are essential for many body functions such as building cell membranes, brain functioning and to synthesize hormones.

Composition with auxiliary protection effect on alcoholic liver injury and preparation method thereof

InactiveCN104172159ASuitable for useScientific and reasonable formula designOrganic active ingredientsDigestive systemSalvia miltiorrhizaSemen
The invention discloses a composition with an auxiliary protection effect on an alcoholic liver injury and a preparation method of the composition. The composition with the auxiliary protective effect on the alcoholic liver injury is mainly prepared from the following raw materials in parts by weight: 57.5-172.5 parts of kudzuvine root extract, 22.5-67.5 parts of semen hoveniae extract, 35-105 parts of salvia miltiorrhiza extract, 18-57 parts of turmeric extract and 7.5-22.5 parts of ammonium glycyrrhetate. The raw materials respectively have anti-lipid peroxidation effect and protective effect on the liver. Functional tests show that the composition with the auxiliary protection effect on the alcoholic liver injury has better liver protection effect compared with the same dose of single kudzuvine root extract preparation and single semen hoveniae extract preparation, and liver fatty degeneration and liver lipid peroxidation which are caused by the alcoholic liver injury can be obviously alleviated. The composition with the auxiliary protection effect is prepared by adopting a scientific and reasonable production process, is definite in functions, controllable in quality and safe to take and is applicable to a large group of people suffering from the alcoholic liver injury.
Owner:BEIJING ZHONGTAI TIANHE SCI & TECH

Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments

The invention discloses Lachnum sp., an extracellular polysaccharide thereof and application of the extracellular polysaccharide in preparing lipid-lowering liver-favoring medicaments. The invention is characterized in that a Lachnum sp. strain with the collection number of CCTCC (China Center for Type Culture Collection) No: M 2011196 is activated and inoculated to a fermentation culture medium, thus preparing the Lachnum sp. extracellular polysaccharide. When the administration dosage is 150-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the levels of serum lipid and liver lipid and atherosis index of high-lipid mice, and increase the level of serum high-density lipoprotein cholesterol and the excretion amount of feces lipid. When the administration dosage is 75-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the activity of serum aminotransferase and malondialdehyde content in liver tissues of high-lipid mice, and increase the activity of sudismase in the liver tissues. The prepared Lachnum sp. extracellular polysaccharide has obvious effects of lowering blood lipid, lowering liver lipid, and treating hepatic injury and dysfunction caused by high lipid, has no toxic or side effects, and can be prepared into tablets or capsules for clinical application.
Owner:HEFEI UNIV OF TECH

Agent for preventing or ameliorating obesity

The present invention provides a method for preventing or ameliorating obesity, for inhibiting accumulation of visceral fat, for inhibiting accumulation of liver lipid, for preventing or ameliorating fatty liver, including using a material for a pharmaceutical product or food, which has inhibitory actions on body weight increase, accumulation of visceral fat and accumulation of liver lipid. The present invention is also directed to a method for preventing or ameliorating obesity, a method for inhibiting accumulation of visceral fat, a method for inhibiting accumulation of liver lipid, and a method for preventing or ameliorating fatty liver, which methods include administering potassium alginate to a subject in need thereof or having the subject take potassium alginate.
Owner:KAO CORP

Application of E3 ubiquitin ligase RNF14 in preparation of drug for treating fatty liver and related diseases

The invention discloses application of E3 ubiquitin ligase RNF14 in preparation of a drug for treating fatty liver and related diseases, and belongs to a new use of the RNF14. In the present invention, a L02 cell line overexpressed by human normal liver cell line L02 and the RNF14 is used as an experimental object, and the gene function of the RNF14 is studied by a fatty liver cell model co-induced by palmitic acid (PA) and oleic acid (OA). The study finds that RNF14 overexpression can significantly improve lipid accumulation in liver cells, indicating that the RNF14 can protect the liver cells from fatty degeneration, and the RNF14 plays a protective role in liver lipid metabolic diseases. Since the RNF14 is an endogenous protein kin the body, the RNF14 is highly safe as the drug.
Owner:WUHAN UNIV

Functional beverage

The invention relates to a functional beverage. The functional beverage is prepared by mixing fruit juice, taurine, lysine, phosphatide, egg fat, octadecanol, myo-inositol, vitamin B1, vitamin B2, vitamin B6, vitamin B12, pantothenic acid, glucose and water. According to the functional beverage disclosed by the invention, various functional compositions are scientifically merged into the functional beverage, are matched each other, and are in synergistic reaction, so that the metabolism of human bodies can be promoted, the absorption and the decomposition of sugar contents can be promoted, a large number of energy substances are rapidly complemented, the functions of a nervous system are regulated, and the functional beverage has the functions of refreshing, restoring consciousness, complementing physical strength, improving organism endurance, increasing a basal metabolism rate, improving the metabolism of serum lipids, preventing arteriosclerosis, and improving the metabolism of liver lipid; besides, the beverage does not contain caffeine and excessive electrolytes, and when the functional beverage is drunk, damage of excessive caffeine and electrolytes to human bodies can be avoided.
Owner:合肥维巧食品科技有限公司

Liver protecting liquor and preparation method thereof

InactiveCN108285850AHas the function of protecting the liverAvoid damageDigestive systemAlcoholic beverage preparationAlcoholismsThirst
The invention relates to the technical field of wine brewing, in particular relates to liver protecting liquor and a preparation method thereof. Calendula, silybum marianum, Cynara scolymus, flower ofkudzuvine, root of kudzu vine, parsley and grains are fermented together, the calendula can fully play the effect of alleviating alcohol poisoning, tonifying liver, reducing total liver lipid, cholesterol and triglyceride; the silybum marianum activates the regeneration of liver proteins, restores the activity of damaged liver cells, and reduces damage of toxins to the liver; the Cynara scolymusincreases liver viability to promote elimination of the toxins in the liver and promotes the regeneration of the liver cells; the flower of kudzuvine is combined to play the role of activating spleen,relieving alcoholism, and stop bleeding; the root of kudzu vine has the effects of relieving muscles, clearing heat, engendering liquid and allaying thirst, the parsley has the effects of calming theliver, reducing blood pressure, tranquilizing and allaying excitement, and the like, alcohol damage to the liver is reduced, nutrient content of the wine is increased, and finally the liver protecting liquor has the effects of dilating blood vessels, lowering blood pressure, removing lipids in the blood, protecting liver, preventing arteriosclerosis and protecting cardiovascular system is obtained.
Owner:普安县应宏酒厂

Method for evaluating influence of ionic liquid on lipid metabolism by using zebra fish

The invention relates to the field of environmental toxicology models, in particular to a method for evaluating the influence of ionic liquid on lipid metabolism by using zebra fish. According to theinvention, zebra fish is used as an experimental object; and after acute exposure of the zebra fish in an ionic liquid with a certain concentration, related hormones influencing liver metabolism, physiological and biochemical indexes related to liver metabolism and expression of liver lipid metabolism related genes are determined, and histological slices of the liver are observed. By analyzing thechange of the indexes of the exposed zebra fish, the influence of the ionic liquid on the liver lipid metabolism toxicity is comprehensively and accurately evaluated. Thus, a basis is provided for formulating aquatic ecological environment pollutant standards.
Owner:JIANGSU UNIV

Preparations of rosa laevigata fruit extracts and uses thereof for regulation of cd36, apoa1, and srb1

InactiveUS20180296624A1Increase gene expressionReducing liver lipid accumulationMetabolism disorderDigestive systemAlcoholBlood lipids
Provided is a method of a method of preparing a Rosa laevigata fruit extract which regulates CD36, ApoA1, and SRB1, including extracting the fruit of Rosa laevigata using water, alcohols, or mixtures of water and alcohols as solvents. Also provided is a method of regulating CD36, ApoA1, and SRB1, including administering to a subject a composition containing an effective amount of the Rosa laevigata fruit extract. By suppressing the gene expression of CD36 and enhancing the gene expression of ApoA1 and SRB1, the Rosa laevigata fruit extract may be used to regulate lipid metabolism and reduce liver lipid accumulation and blood lipid levels.
Owner:TCI CO LTD

(Pro) resin receptor (P) RR gene and application of inhibitor of gene

The invention discloses a function and application of a (pro) resin receptor [(pro) resin receptor, (P) RR] inhibitor in nonalcoholic fatty livers and fat diseases. Under the background of C57 mice, (P) RR liver specificity knock-out/know-down mice are used as experimental objects, according to a fat mouse model which is induced through high-fat feed, and it is proved through a result that the size of the liver (P) RR knock-out mice is remarkably small, and the fat tissue in the mouse bodies is remarkably reduced; after the mice are fed with the high-fat feed, the increase amplitude of the weight of the mice is low, fat is not generated, the blood glucose content is low, through results of oil red dyeing, liver lipid measurement and the like, it is explained that the liver function of theliver (pro) resin receptor knock-out mice is remarkably better than that of contrasted fatty mice, the fatty liver lesion of the mice is remarkably improved, the stored lipid is remarkably reduced, and the blood glucose content is lowered. Therefore, (P) RR can be used as a medicine target of screening treatment of type-II diabetes, nonalcoholic fatty livers and fat diseases, and the inhibitor of(P) RR can be applied to preparation of medicine for treating type-II diabetes, nonalcoholic fatty livers and fat diseases.
Owner:SHENZHEN UNIV

Traditional Chinese medicine composition for improving insulin resistance syndrome and compound preparation and application thereof

InactiveCN108186909AReduce hepatic lipid ectopic accumulationPromote functional recoveryPowder deliveryCapsule deliverySerum insulin levelPolypill
The invention belongs to the technical field of medicine healthcare, and discloses a traditional Chinese medicine composition for improving the insulin resistance syndrome and a compound preparation and application thereof. The traditional Chinese medicine composition is prepared from 15-20 g of radix adenophorae, 9-15 g of radix pueraiae, 12-18 g of radix ophiopogonis, 15-20 g of radix rehmanniaepraeparata, 9-15 g of fructus corni, 9-15 g of radices trichosanthis, 27-33 g of dendrobe, 12-18 g of Chinese yam, 15-20 g of radix rehmanniae recen, 12-18 g of radix pseudostellariae, 12-18 g of radix astragali, 15-20 g of fructus lycii, 12-18 g of fructus ligustri lucidi, 9-15 g of rhizoma atractylodis macrocephalae, 9-15 g of radix aucklandiae, 12-18 g of rhizoma anemarrhenae, 9-15 g of radixsalviae miltiorrhizae and 9-15 g of radix scutellariae. The traditional Chinese medicine composition can remarkably reduce the weight, blood fat, serum insulin level of a II-type diabetes rat and improve the As index and insulin tolerance, remarkably reduces the ectopic accumulation of liver lipid of the II-type diabetes rat and promotes the function restoration of islet cells.
Owner:HUBEI UNIV FOR NATITIES

Application of CPT-II in malignant transformation process induced by fat accumulation of liver cells

The invention provides application of CPT-II in the malignant transformation process induced by fat accumulation of liver cells. The application comprises the following steps of animal grouping, model preparing, blood enzymology and lipid detecting, liver cell fat staining, liver tissue protein preparing and concentration determining, quantitative analysis on the liver CPT-II concentration, pathologic histology examining, liver CPT-II immuohistochemistry staining and statistical analyzing. According to the application, by establishing fatty liver and liver mouse models and detecting changes of the CPT-II in the liver cell malignant transformation process, it is found that the CPT-II content in the fatty liver model is obviously lower than that of a normal control group, it shows that decrease of the liver cell CPT-II can be caused by liver lipid accumulation and fat degeneration, the CPT-II content of a liver cancer mouse model is significantly lower than that of the fatty liver model, and therefore the CPT-II content is in negative correlation with the liver cell malignancy grade. The liver CPT-II specific concentration and immunohistochemistry prove that the liver cells are progressively decreased in the canceration process, it shows that fat accumulation of the liver cells is aggravated due to low expression or dysfunction of the CPT-II, and a promoting effect is achieved on the liver cell maglignancy transformation process.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV

Functions and applications of centrifugal force and shearing stress response gene 1 in fatty liver and diabetes mellitus

The invention discloses functions and applications of RECS1 in the fatty liver and the diabetes mellitus, and belongs to the field of functions and applications of genes. An RECS1 gene knockout mouse and a wild type C57 mouse are used as experimental subjects, through a model of the fatty liver and the diabetes mellitus which are induced by high-fat diets, the result shows that compared with the wild type C57 mouse, glycometabolism of the RECS1 gene knockout mouse is disorderly, fatty liver lesion is severe, and lipid accumulation is remarkably increased. It explains that the RECS1 has the adjustment and control capacity for maintaining the steady state of glycometabolism and has the liver lipid removal capacity and fatty liver forming resistance. Thus, the functions of the RECS1 in the fatty liver and the diabetes mellitus are found and the functions are mainly reflected in the effects on alleviating fatty liver and diabetes mellitus. For the functions of the RECS1, the RECS1 can be used for preparing medicine for treating the fatty liver and the diabetes mellitus.
Owner:武汉惠康达科技有限公司
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