The invention relates to the technical field of wine brewing, in particular relates to liver protecting liquor and a preparation method thereof. Calendula, silybum marianum, Cynara scolymus, flower ofkudzuvine, root of kudzu vine, parsley and grains are fermented together, the calendula can fully play the effect of alleviating alcohol poisoning, tonifying liver, reducing total liver lipid, cholesterol and triglyceride; the silybum marianum activates the regeneration of liver proteins, restores the activity of damaged liver cells, and reduces damage of toxins to the liver; the Cynara scolymusincreases liver viability to promote elimination of the toxins in the liver and promotes the regeneration of the liver cells; the flower of kudzuvine is combined to play the role of activating spleen,relieving alcoholism, and stop bleeding; the root of kudzu vine has the effects of relieving muscles, clearing heat, engendering liquid and allaying thirst, the parsley has the effects of calming theliver, reducing blood pressure, tranquilizing and allaying excitement, and the like, alcohol damage to the liver is reduced, nutrient content of the wine is increased, and finally the liver protecting liquor has the effects of dilating blood vessels, lowering blood pressure, removing lipids in the blood, protecting liver, preventing arteriosclerosis and protecting cardiovascular system is obtained.