The invention publishes the preparation methods to produce ass hide and ginseng and stibene wine. This medicated wine has function of curing and health protection. The distilled spirit acts as groundsustance for ass hide and ginseng and stibene wine and then dip ginseng, prepared rehmannia root, dangshen, medlar, astragalus root, angelica, poria conos, licorice root, chuanxiong rhizome, white fat peony and bighead atractylodes rhizome, after this, add ass hide and sugar liquor to get the medicated wine. The thirteen good drug are mixed reasonably, the distilled spirit is used to dip and distill and sugar is used to season, so the drug can be absorbed by men. The invention has many function, such as helping buiding blood and invigoratin qi, strengthening the spleen and stomach, nourishing the heart and tranquilization, nourishing yin and moisturizing the lung, promoting blood circulation and improving acuity of vision and refreshment. It is good for not only weaken habitus but also blood vessel of brain and heart and gynecology illness.