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Traditional Chinese medicine composition for relieving nonalcoholic steatohepatitis and preparation method and product thereof

A steatohepatitis, non-alcoholic technology, applied in the field of medicine, can solve the problem of incompletely clear pathogenesis, and achieve the effect of reducing liver lipid accumulation, reducing swelling, and improving liver pathological changes

Active Publication Date: 2019-10-18
SHENZHEN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the pathogenesis of NASH is still not completely clear, and existing theories believe that it occurs under the joint action of multiple factors such as lipotoxicity, intestinal tract, and inflammation.

Method used

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  • Traditional Chinese medicine composition for relieving nonalcoholic steatohepatitis and preparation method and product thereof
  • Traditional Chinese medicine composition for relieving nonalcoholic steatohepatitis and preparation method and product thereof
  • Traditional Chinese medicine composition for relieving nonalcoholic steatohepatitis and preparation method and product thereof

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Experimental program
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preparation example Construction

[0028] The present invention also provides a preparation method of a Chinese medicine composition, comprising the steps of:

[0029] Step 1, weigh capillary, hedyotis diffusa, gardenia root and mulberry root according to the formula ratio;

[0030] Step 2, it is prepared by mixing Capillaris, Hedyotis diffusa, Gardenia root, and Sangjisi according to the mass ratio, and then carrying out water extraction; The mixture was boiled in pure water for 40 minutes and the decoction was separated.

[0031] Step 3: Concentrate the decoction obtained after water extraction to obtain the traditional Chinese medicine composition. The concentration process is as follows: use a rotary evaporator to remove the solvent in the decoction liquid, then use pure water to dissolve the solute into a solution with a concentration of 3-5g / mL crude drug, and finally use a microporous membrane to filter to obtain; preferably, use pure water Dissolve the solute into a solution with a crude drug concentr...

Embodiment 1

[0036] A kind of Chinese medicine composition, comprises each component of following weight fraction:

[0037] 25 parts of capillary, 25 parts of Hedyotis diffusa, 12.5 parts of gardenia root, 12.5 parts of mulberry.

[0038] A preparation method of Chinese medicine composition:

[0039] (1) Boil in pure water for 40 minutes after mixing the capillary, Hedyotis diffusa, Gardenia root, and mulberry, and separate the decoction;

[0040] (2) Use a rotary evaporator to remove the solvent in the decoction liquid, then dissolve the solute into a solution with a crude drug concentration of 3g / mL with pure water, and finally filter with a 22 μm microporous membrane to obtain the traditional Chinese medicine composition.

Embodiment 2

[0042] A kind of Chinese medicine composition, comprises each component of following weight fraction:

[0043]25 parts of capillary, 25 parts of Hedyotis diffusa, 12.5 parts of gardenia root, 12.5 parts of mulberry.

[0044] A preparation method of Chinese medicine composition:

[0045] (1) Boil in pure water for 40 minutes after mixing the capillary, Hedyotis diffusa, Gardenia root, and mulberry, and separate the decoction;

[0046] (2) Use a rotary evaporator to remove the solvent in the decoction, then dissolve the solute into a solution with a crude drug concentration of 4g / mL with pure water, and finally filter with a 22 μm microporous membrane to obtain the traditional Chinese medicine composition.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for relieving nonalcoholic steatohepatitis and a preparation method and product thereof. The traditional Chinese medicine compositionis prepared from herba artemisiae scopariae, spreading hedyotis herbs, gardenia jasminoides ellis and herba taxilli at the ratio being 1:(0.8-1.5):(0.2-1.2):(0.2-1.2), the ingredients are water-extracted and then concentrated, and the traditional Chinese medicine composition is obtained. The traditional Chinese medicine composition can be made into a health care product or a medicine, and has animportant effect on alleviating the nonalcoholic steatohepatitis. Experiments prove that the traditional Chinese medicine composition can effectively relieve liver swelling, improve pathological changes of the liver, reduce liver lipid accumulation, lower the liver inflammatory factor level and effectively relieve NASH.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition capable of relieving nonalcoholic steatohepatitis, a preparation method and a product thereof. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disease characterized by lipid deposition in hepatocytes and other causes of liver damage excluded, and its disease spectrum includes nonalcoholic steatohepatitis (NASH), fibrosis, liver Cirrhosis and hepatocellular carcinoma. With the change of people's lifestyle and diet structure, the global incidence of NAFLD has reached about 25.24%. The data shows that about 59% of NAFLD patients who received liver biopsy have developed into NASH. NASH is a subtype of NAFLD, which is the coexistence of hepatic steatosis, liver injury and inflammation. It is worth noting that NASH has become the second most common indication for liver transplantation, and it is a necessary...

Claims

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Application Information

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IPC IPC(8): A61K36/748A61P1/16A23L33/105
CPCA23V2002/00A61K36/185A61K36/282A61K36/744A61K36/748A61K2236/331A23L33/105A61P1/16A61K2300/00A23V2200/32A23V2200/3262
Inventor 曾小斌肖凌云梁曙江程葛岚岚万浩强吴伟刚周伯平
Owner SHENZHEN PEOPLES HOSPITAL
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