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Method to prepare ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease

一种灵芝多糖、脂肪肝的技术，应用在含有效成分的医用配制品、医药配方、有机活性成分等方向

Active Publication Date: 2017-02-15
CHANG GUNG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is still unknown whether this mushroom can have a beneficial effect on fatty liver disease

Method used

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  • Method to prepare ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease
  • Method to prepare ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease
  • Method to prepare ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease

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Effect test

Embodiment 1

[0023] Preparation method of Ganoderma lucidum polysaccharide of the present invention

[0024] The Ganoderma lucidum polysaccharide of the present invention has a molecular weight greater than 135kDa and can be effectively used to reduce liver weight and liver fat content. The Ganoderma lucidum polysaccharide of the present invention can be added to the diet, which can be a drink, a daily supplement or a food, does not require much change in lifestyle, and does not cause toxins or adversely affect health.

[0025] 1.1 Preparation steps of Ganoderma lucidum water-soluble extract concentrate of the present invention

[0026] figure 1 It is a method showing the separation of polysaccharides from Ganoderma lucidum mycelium. First, mix 10L of distilled water with dry liquid fermented Ganoderma lucidum mycelium (500g) obtained by Chang Gung Biotechnology Co., Ltd. (Taipei, Taiwan) to form a mixed liquid (50g / L), in which the solid to liquid ratio is 5% (w / v), using a 20-liter stirred r...

Embodiment 2

[0063] The effect of the Ganoderma lucidum polysaccharide of the present invention on the treatment of fatty liver disease in high-fat diet mice (High-Fat Diet-fed, HFD-fed)

[0064] Image 6 Shows the effect of Ganoderma lucidum polysaccharide fraction (G1, G2, G3 and G4) on the liver of high-fat diet mice. Male mice of C57BL / 6NCrlBltw at 8 weeks were randomly divided into 10 groups, 5 in each group. Mice are fed standard chow feed (13.5% of energy source is fat) or high-fat feed (60% of energy source is fat), and 100μL of Ganoderma lucidum polysaccharide fraction (G1, G2, G3, and G4) or distilled water treatment for two months, respectively HFD+G1, HFD+G2, HFD+G3, HFD+G4, HFD, Chow+G1, Chow+G2, Chow+G3, Chow+ G4 and Chow group. Then sacrifice the mice and weigh their livers as Image 6 A. Image 6 In the liver tissue, lipids are stained with oil red O (ORO) ( Image 6 B) and quantify the degree of staining with Image J software ( Image 6 C), showing that the Ganoderma l...

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Abstract

The present invention provides a method to prepare polysaccharides from Ganoderma lucidum. The prepared polysaccharides can reduce liver weight and liver lipid content in humans and animals. The prepared polysaccharides can therefore be used to prevent and treat fatty liver disease.

Description

Technical field [0001] The invention relates to the use of Ganoderma lucidum polysaccharide. Furthermore, the present invention provides a method for preparing Ganoderma lucidum polysaccharide and its use as a form of inhibiting fatty liver. Background technique [0002] Fatty liver is a condition in which large vacuoles of triglycerides accumulate in the liver. This situation mostly occurs in the liver of alcohol abuse or obese individuals. Fatty liver is usually associated with inflammation and is called steatohepatitis. In the long term, fatty liver disease may cause several complications, including cirrhosis, liver tumors, and death. At present, the high prevalence of fatty liver makes it a major threat to public health, and the prevalence of its global population is about 10 to 24%. Therefore, in modern society, the prevention and treatment of fatty liver has become a major goal. [0003] Traditional Chinese medicine has a long history in Asian countries, dating back thou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P1/16C08B37/00
CPCA61K31/715A61K36/074A61K2236/00A61P1/16C08B37/0003
Inventor 柯云飞马奕安廖建清张义德简玮廷林美凤杨嘉蓁邱振尧张志荣林诠盛吴宗儒陆嘉真欧大卫赖信志杨定一
Owner CHANG GUNG BIOTECH
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