136 results about "Fat diet" patented technology

The subject disclosure provides compositions for reducing serum cholesterol and / or triglyceride levels in subjects. These compositions can comprise racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject. Alternatively, compositions comprising racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol, R-1,3 butandiol or combinations thereof can be formulated as nutritional supplements (also referred to as nutritional compositions) or incorporated into therapeutic compositions containing a) anti-hypertensive agents; b) anti-inflammatory agents; c) glucose lowering agents; or d) anti-lipemic agents) which are administered to a subject, optionally in combination with a low fat diet, in order to cause a reduction or lowering of: serum cholesterol levels; triglyceride levels; serum glucose levels, serum homocysteine levels, inflammatory proteins (e.g., C reactive protein) and / or hypertension in treated subjects. Alternatively, compositions disclosed herein can be administered alone, or in combination with other therapeutic agents to prevent or reverse vascular disease.

The invention relates to a preparation method for papaya extract and the novel use of the papaya extract for the treatment of hepatic fibrosis. The preparation method comprises the steps of papaya extraction, extraction separation, resin adsorption and the like. According to the preparation method and the use, a high-fat diet molding technology is used for making researches on the use and effects of the papaya extract in an animal body, and experimental results show that the papaya extract has high liver protection and lipid lowering activity and good curative effects on hepatic fibrosis and can remarkably inhibit hepatic fibrosis.

Fatty liver was induced by administering agents for inducing organ inflammation to experimental animals to evoke insulin resistance and by rearing them with high-fat diets. As a result, steatohepatitis was successfully induced in the animals. The animals show pathological findings similar to those of humans. By using these model animals, substances for treating or preventing diseases can be efficiently screened and the efficacy of medicinal substances can be effectively evaluated.

The invention discloses a building method of a dampness-heat asthma animal model. The method comprises the following steps of using high-fat diet to feed a rat, filling colibacillosis, and forming a dampness-heat syndrome type of the rat; when the high-fat diet is fed, using albumen and aluminium hydroxide normal saline mixing suspension liquid to sensitize the rat; after sensitizing, activating by the albumen normal saline solution, so as to obtain the dampness-heat asthma animal model. The method has the advantage that the traditional asthma animal model is organically combined with the traditional Chinese dampness-heat syndrome type animal model to form the traditional Chinese dampness-heat syndrome type asthma animal model, so as to apply for the traditional Chinese clinical asthma study, and facilitate the study of traditional Chinese asthma relieving medicine sieving.

The invention provides new compositions or combinations thereof for the treatment of cancer. More specifically, the invention provides compositions or combinations thereof for cancer treatment including a high-fat diet. Specifically, the high-fat diet is characterized by having approximately 120 g / day or more, or approximately 70% or more of the total daily energy, from fat, based on a real weightof 50 kg. The diet is preferably a carbohydrate-restricted high-fat diet, and more preferably provided by a ketone formula and / or MCT oil. The dietary therapy by a high-fat diet of the present invention is provided along with surgical treatment, chemotherapy or radiation therapy, or combinations thereof.

The invention discloses a function of tumor progress site 2 in treatment of fatty liver and type 2 diabetes as well as an application thereof. According to the invention, TPL2 gene knockout mice and wild type mice are taken as the experiment objects, through a high-fat diet-induced obesity mice model, the result shows that compared with the wild type C 57 mice, body weight of the TPL2 gene knockout mice is mitigated, the fasting blood glucose level is lower than that of a control group WT mice, and the hepatic dysfunction is obviously mitigated. Through intraperitoneal glucose tolerance experiment, the endurance of the TPL2 gene knockout mice on glucose is obviously enhanced. the mice liver tissue cholesterol content change result instructs that TPL2-KO mice fatty liver pathology of a HFD group (High fat diet) is obviously mitigated, and the lipid accumulation is obviously reduced. TPL2 can be taken as a drug target for treating fatty liver and / or type 2 diabetes, and its inhibitor can be used for preparing a drug to treating fatty liver and / or type 2 diabetes.

The invention belongs to the field of medicines, and relates to an isoindoline derivative compound, a preparation method and weight-losing application. The structural formula of the isoindoline derivative compound is shown as a formula I. The compound prepared by the invention can effectively reduce the weight of a mouse induced by high-fat diet and reduce the content of liver fat and epididymis fat, has a good weight-reducing effect, and can be used for preparing weight-reducing related medicines or health-care products.