223 results about "Serum cholesterol" patented technology

A method for the treatment or prophylaxis of hypertriglyceridemia and hypercholesterolemia without concomitantly increasing LDL-serum cholesterol, in a human subject requiring such treatment, which method comprises orally administering to the patient an effective amount of a pharmaceutical composition in which the active ingredients comprise a mixture of fatty acids, wherein said mixture comprises at least about 60% by weight a combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from about 1.4:1 to about 5:1, wherein said combination is at least about 60% in the triglyceride form of the fatty acids and the balance is at least about 80% of mono and di-glycerides.

Hydroxy-substituted azetidinone hypocholesterolemic agents of the formulaor a pharmaceutically acceptable salt thereof, wherein:Ar1 and Ar2 are aryl or R4-substituted aryl;Ar3 is aryl or R5-substituted aryl;X, Y and Z are -CH2-, -CH(lower alkyl)- or -C(dilower alkyl)-;R and R2 are -OR6, -O(CO)R6, -O(CO)OR9 or -O(CO)NR6R7;R1 and R3 are H or lower alkyl;q is 0 or 1; r is 0 or 1; m, n and p are 0-4; provided that at least one of q and r is 1, and the sum of m, n, p, q and r is 1-6; and provided that when p is O and r is 1, the sum of m, q and n is 1-5;R4 is selected from lower alkyl, R5, -CF3, -CN, -NO2 and halogen R5 is selected from -OR6, -O(CO)R6, -O(CO)OR9, -O(CH2)1-5OR6, -O(CO)NR6R7, -NR6R7, -NR6(CO)R7, -NR6(CO)OR9, -NR6(CO)NR7R8, -NR6SO2R9, -COOR6, -CONR6R7, -COR6, -SO2NR6R7, S(O)0-2R9, -O(CH2)1-10-COOR6, -O(CH2)1-10CONR6R7, -(lower alkylene)COOR6 and -CH=CH-COOR6;R6, R7 and R8 are H, lower alkyl or aryl-substituted IcR9 is lower alkyl, aryl or aryl-substituted lower alkyl;are disclosed, as well as a method of lowering serum cholesterol by administering said compounds, alone or in combination with a cholesterol biosynthesis inhibitor, pharmaceutical compositions containing them; and a process for preparing them.

A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are either absent from the intended sample or insufficiently present therein to permit completion of the desired reaction, are predeposited as substrate in dry form together with ingredients necessary to produce a desired color upon occurrence of the desired reaction. The strip is equipped with a sample pad placed ahead of the substrate deposit in the flowstream, to which liquid sample is applied. The sample flows from the sample pad into the substrate zone where it immediately reconstitutes the dried ingredients while also intimately mixing with them and reacting with them at the fluid front. The fluid front moves rapidly into the final “read zone” wherein the color developed is read against predetermined color standards for the desired reaction. Pretreatment pads for the sample, as needed, (e.g. a lysing pad for lysing red blood cells in whole blood) are placed in front of the sample pad in the flow path as appropriate. The assay in the format of the invention is faster and easier to perform than analogous wet chemistry assays.Specific assays for glucose-6-phosphate dehydrogenase (“G-6PD”), total serum cholesterol, β-lactamase activity and peroxidase activity are disclosed.

The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and / or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and / or high triglycerides and / or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are either absent from the intended sample or insufficiently present therein to permit completion of the desired reaction, are predeposited as substrate in dry form together with ingredients necessary to produce a desired color upon occurrence of the desired reaction. The strip is equipped with a sample pad placed ahead of the substrate deposit in the flowstream, to which liquid sample is applied. The sample flows from the sample pad into the substrate zone where it immediately reconstitutes the dried ingredients while also intimately mixing with them and reacting with them at the fluid front. The fluid front moves rapidly into the final "read zone" wherein the color developed is read against predetermined color standards for the desired reaction. Pretreatment pads for the sample, as needed, (e.g. a lysing pad for lysing red blood cells in whole blood) are placed in front of the sample pad in the flow path as appropriate. The assay in the format of the invention is faster and easier to perform than analogous wet chemistry assays. Specific assays for glucose-6-phosphate dehydrogenase ("G-6PD"), total serum cholesterol, beta-lactamase activity and peroxidase activity are disclosed.

The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear steroid metabolite that increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and / or triglycerides. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and / or high triglycerides (e.g. hypercholesterolemia, hyperlipidemia, and atherosclerosis) are also provided.

The invention relates to a method for producing sweet potato residue biscuits. The method comprises the following steps of rinsing sweet potato residues with water, filtering and draining with a strainer, and dissolving and mixing oil, eggs and white sugar in a water bath; adding low-gluten flour and wet or dry potato residues, after fully mixing, kneading into a dough, and pressing into a wrapper with a thickness of 2-4mm by a dough pressing machine; and processing the wrapper into a shape meeting the requirement by using a biscuit die, baking and cooking to obtain sweet potato residue biscuits. The wet or dry sweet potato residues with high content of dietary fiber are used as a raw material, and the total dietary fiber and soluble dietary fiber content of the produced biscuits is high; on the basis of keeping the color, smell and taste of original biscuits, vitamins, niacin, folic acid and other nutrients are added; the biscuit can be used as a diet food and a food for regulating blood sugar, blood pressure and serum cholesterol; the sweet potato residues have better adaptability to flour, and the forming effect is good; the biscuit does not contain toxic, hazardous and carcinogenic matters and is safe to eat; the process is simple, the continuity is good, the operation cost is low, and the utilization rate is high; and in the production process, the produced waste is less, and the environment is not polluted.

The invention relates to a functional lactobacillus plantarum plant subspecies having a holesterol lowering function and a preparation method of a compound bacterial powder of the plant subspecies, and belongs to the application fields of functional food and microecologics. According to the preparation method, the lactobacillus plantarum plant subspecies Zhang-LL CGMCC No. 6936 is used for preparing Zhang-LL strain freeze-dried powder by virtue of culture activation, fermentation, bacterial sludge collection and freeze-drying, and the viable count of the freeze-dried powder is 3.50*10<11> CFU / g. Bacillus natto BNZ3 CGMCC No. 9146 is used for preparing bacillus natto power by virtue of culture activation, enlarged cultivation, fermentation and drying, and the activity of nattokinase in the bacillus natto power is 2000IU / g; monacus purpureus Zhang-MP CGMCC No. 9221 is used for preparing monacus purpureus powder by virtue of culture activation, enlarged cultivation, solid-state fermentation, drying and grinding; as being tested, the content of the active substance Monacolin K in the monacus purpureus powder is 4.98mg / g. The prepared lactobacillus plantarum plant subspecies powder is thoroughly mixed with the bacillus natto power and the monacus purpureus powder in the ratio of 1:1:1(w / w), thereby obtaining compound bacterial powder having the serum cholesterol lowering effect.

The invention relates to a health preserving coarse cereal having a health-care function. The health preserving coarse cereal is prepared from wheat, barley, peas, mung bean, oat, buckwheat, black glutinous rice, red bean, Chinese yam, corn, seeds of Job's tears, black soya bean, chrysanthemum, carrot, root of spinach, white gourd and pumpkin by weight, has the effects of softening blood vessels, stabilizing blood sugar, lowering down serum cholesterol, preventing outbreak of cancers, hypertension and coronary heart disease, increasing the concentration of histamine, enabling peripheral blood vessels to expand, reducing blood pressure, enabling internal secretion to maintain normal and delaying aging, and is extremely easy to popularize.

The present invention relates to compositions and methods for the reduction of atherosclerotic plaques and the decrease in the level of total serum cholesterol, triglycerides, serum LDL cholesterol, and serum HDL cholesterol.

The invention discloses a deep seawater concentrate having an effect of reducing serum cholesterol and a manufacturing method thereof. The deep seawater concentrate has the hardness of 385000 to 415000mg / l, salinity of 38 to 43%, a magnesium concentration of 90000 to 105000mg / l and a sodium concentration of 7800 to 9500mg / l. The deep seawater concentrate comprises mineral matters such as potassium, calcium, iron, zinc, molybdenum, manganese, lithium, strontium, copper or silicon. The deep seawater concentrate can be used for a plurality of target industries such as food processing, agricultural development, biopharmacy, cosmetic and skin care product manufacture, healthy food exploitation and beverage production.

The invention discloses a cardiovascular disease risk prediction network model based on multiple parameters and a construction method thereof, relates to a risk prediction model, and solves the problems that an existing cardiovascular disease risk prediction model cannot predict multiple physiological parameters and is not ideal in prediction effect. The method comprises the following steps: establishing a cardiovascular disease data set; preprocessing the data set data, and dividing the data set into a training set and a test set according to the ratio of the number of the training set data to the number of the test set data being 7: 3; performing model construction: both the training set and the test set comprise samples and labels, model training is conducted on training set data through the minimum error of forward propagation and reverse propagation in the training process, and the trained model is evaluated through the test set data. The risk of suffering from cardiovascular diseases is evaluated by detecting multiple physiological parameters such as age, gender, chest pain type, resting blood pressure, serum cholesterol, fasting blood glucose, resting electrocardiogram, maximum heart rate and the like of a person.

A 2,3,5,4'-tetrahydroxy distyrene-2-O-beta-D-glucoside used for hypoglycemic medicine is prepared from the decoction of fleece flower root through extracting, separating and purifying. It can suppress the increasement of serum cholesterol, decrease low-density serum lipoprotein cholesterol and improve activity of liver esterase.

The invention discloses a preparation method of extract of effective part of Clinopodium chinense (Benth.) O. Kuntze for preventing and treating diabetes and an application thereof. The extract of the effective part is prepared from Clinopodium chinense (Benth.) O. Kuntze as a raw material, a concentrate is obtained by pulverizing, ethanol extraction and reduced pressure recovery, the concentrate is extracted by petroleum ether and ethyl acetate, and the obtained ethyl acetate extract is purified by macroporous resin. The extract of the effective part mainly comprises total flavone and terpenoids, and has obvious effects of reducing blood sugar of rats with streptozotocin diabetes, reducing the content of serum cholesterol, protecting the islet cells, inhibiting the activity of alpha-glucosidase, and protecting the vascular endothelial cells. Thus, the extract of the effective part of Clinopodium chinense (Benth.) O. Kuntze has favorable functions for reducing blood sugar, reducing blood fat, and protecting the islet cells and the vascular endothelial cells, and can be used for preventing and treating diabetes, dyslipidemia induced by diabetes and diabetic cardiovascular and cerebrovascular complications.

Cholesterol-uptake-blocking drugs inhibit angiogenesis and are useful to inhibit diseases perpetuated by angiogenesis. Cholesterol reduction with the use of the drugs increases the intratumoral level of thrombospondin-1, an angiogenesis inhibitor. Ezetimibe (Zetia®), a specific cholesterol-uptake blocking drug, also retards the growth of human tumors, most preferably in combination with low-cholesterol diet. The pharmacologic reduction in serum cholesterol retards prostate cancer growth by inhibiting tumor angiogenesis to combat the growth of prostatic tumors which are directly accelerated by hypercholesterolemia.

A confectionery chew for lowering serum cholesterol in an animal in need thereof including a carbohydrate, a seeding agent, which can be a fondant, a structuring agent, which can be a protein, a starch, a hydrocolloid, and mixtures thereof, and cholesterol lowering agent selected from a sterol, a sterol ester, a stanol, a stanol ester, and mixtures thereof.

The disclosure provides an oral composition for reducing serum cholesterol, serum lipids, body fat, or atherogenic index or for prophylaxis or treatment of atherosclerosis, cardiovascular or cerebrovascular diseases, comprising a highly bsh active bacteria, isolate or supernatant thereof; wherein the highly bsh active bacteria degrades >50[mu]mol glycodeoxycholic acid (GDCA) / gram / hour and >2[mu]mol taurodeoxycholic acid (TDCA) / gram / hour when measured over 1 hour and 5 hours, respectively, or degrades >65 [mu]mol GDCA / g / hr and >7 [mu]mol TDCA / g / hr when measured over 30 minutes.

Novel β-lactam compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof which are useful as serum cholesterol-lowering agents:(I) wherein A1, A3 and A4 represent each hydrogen, halogen C1-5 alkyl, C1-5 alkoxy, —COOR1, a group represented by the following general formula (b): (b) wherein R1 represents hydrogen or C1-5 alkyl, or a group represented by the following general formula (a): (a) wherein R2 represents —CH2OH, —CH2OC(O)—R1 or —CO2—R1; R3 represents —OH or —OC(O)—R1; R4 represents —(CH2)kR5(CH2)1- wherein K and 1 are each 0 or an integer of 1 or above provided k+1 is an integer of not more than 10; and R5 represents a single bond, —CH═CH—, —OCH2—, carbonyl or —CH(OH)—; provided that at least one of A1, A3 and A4 is a group represented by the above formula (a); A2 represents C1-5 alkyl, C1-5 alkoxy, C1-5 alkenyl, C1-5 hydroxyalkyl or C1-5 carbonylalkyl; and n, p, q and r are each an integer of 0, 1 or 2.

The invention discloses an oat beta-glucan oral composition and application thereof. The composition is prepared from the following raw materials in percentage by weight: 75-92.5 percent of oat beta-glucan, 2.5-10 percent of resistant dextrin and 5-15 percent of fructo-oligosaccharide. The dispersibility of oat beta-glucan can be remarkably improved by optimizing the formula, so that the oat beta-glucan can be sufficiently combined with water molecules, the viscosity of the oat beta-glucan can be sufficiently induced, the oat beta-glucan can be distributed in intestinal tracts more uniformly,the effects of reducing blood lipids and blood glucose can be improved, and the flavor and acceptance of products can be remarkably improved. Compared with pure oat beta-glucan, the composition has the effects of remarkably adjusting blood lipids, reducing low density lipoprotein and serum cholesterol and remarkably controlling blood glucose, and has an important meaning for preventing and treating cardiovascular and cerebrovascular diseases and diabetes mellitus.

The invention belongs to the technical field of dairy product processing, and particularly discloses a preparation method for high-activity peptide acidified milk. The method comprises the steps: S1, preparation of a leavening agent; S2, inoculation; S3, two-stage fermentation. According to the method, fermentation strains are screened and are compounded according to a certain ratio, and a two-stage fermentation method is adopted, so that the coordinate symbiosis among various strains gives full play to own characteristic advantages, the acid production, aroma producing and proteolysis capabilities of the strains tend to an optimal state, acidified milk obtained by production has more small molecule peptide than traditional acidophilus milk. Casein and whey protein are both subjected to advanced degradation during a fermentation process, so as to be easily digested and absorbed by a human body, the prepared high-activity peptide acidified milk has the healthcare functions of lowering serum cholesterol, reducing blood glucose, resisting hypertension, resisting oxidation, boosting immunity, improving intestinal function, and the like.

The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and / or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and / or high triglycerides and / or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

The invention relates to an ebony health-care herb tea. The tea is characterized by consisting of the following compositions according to weight percentage: 60 percent of ebony, 30 percent of hawkthorn, 5 percent of malt, 2 percent of dried ginger and 3 percent of liquorice; raw materials are fully and evenly mixed; by weight, one portion of a mixture is added with five portions of water; the mixture is boiled, leached for 72 hours by small fire, filtered and removed with residue; four portions of leached fumet are received; by weight, four portions of the leached fumet is doped with six portions of drinking mineral water to prepare doping liquid; and 1 percent benzoic acid is added into the doping liquid by weight. The beverage prepared contains no sugar, is a safe beverage for a diabetic and is reduced on the basis of the prior traditional Chinese medicine compatibility in order to strength the functions of invigorating spleen, dissolving deposition, promoting qi circulation, dispersing blood stasis, producing secretion and relieving thirsty; moreover, the ebony health-care herb tea can achieve the functions of benefiting gallbladder and lowering blood pressure, blood lipids and serum cholesterol, is suitable for long-term drinking, has sweet and sour taste and good health-care effect for three-high patients and is a beverage for all ages.

The invention discloses a standard serum cholesterol substance and the application thereof. The standard serum cholesterol substance is prepared by a method with the following steps: (a) pellucid bovine serums are chosen and classified according to initial values that are measured by adopting a cholesterase method; (b) a high-concentration cholesterol concentrated solution is prepared by adopting an ultracentrifugation method, and an initial value is measured by adopting the cholesterase method; (c) a preparation concentration is preset, and a preparation proportion is computed for the preparation according to a required preparation content and the bovine serum classification; (d) an antiseptic agent is added; and (e) the product is filtered and separately packaged, wherein, sodium azide is taken as the antiseptic agent, with the usage ratio of 0.1 percent according to the weight and volume ratio, and the filtering carries out the aseptic filtering by using an asbestos filtering plate of 0.2 micrometer. The result of a series of experiments that are implemented by adopting the standard bovine serum cholesterol substance obtained by the invention indicates that the standard substance has small matrix effect, universality in partial systems, uniformity and good stability.

The invention relates to the preparation of a wild cactus polyoses extract and the highly effective function thereof for reducing serum cholesterase. The extract is a polyoses extracted from the natural wild cactus polyoses, and can reduce the total cholesterol content in the hypercholesterolemia and obviously improve the lipid metabolic disturbance by improving the activity of in vivo lipid metabolic key enzyme lecithin cholesterin acylase and reducing the activity of synthetical rate-limiting enzyme 3-hydroxy-3-methyl pentane diacid coenzyme A reductase of liver cholesterin; the invention has no obviouse adverse reaction and can be used for preparing medicines used for lowering the cholesterin.

The present invention relates to a medicine for curing senile dementia. The medicine is composed of capsule and oral liquid; wherein, the capsule contains 16 to 20 portions of red ginseng, 16 to 20 portions of leech and 16 to 20 portions of ground beetles; the oral liquid contains 52 to 60 portions of prepared tuber of multiflower knotweed, 24 to 30 portions of Chinese dodder seed, 16 to 20 portions of cynomorium songaricum, 24 to 30 portions of epimedium herb, 16 to 20 portions of rehmannia root, 16 to 20 portions of common anemarrhena rhizome, 24 to 30 portions of medlar, 26 to 32 portions of radix astragali, 16 to 20 portions of hemlock parsley, 24 to 30 portions of salvia miltiorrhiza, 16 to 20 portions of radix puerariae, 8 to 10 portions of bile arisaema, 8 to 10 portions of grassleaf sweelflag rhizome, 8 to 10 portions of liquorice, 18 to 22 portions of gastrodia tuber and 0.5 to 1 portions of benzoate. The medicine has the efficacies of nourishing bone marrow, strengthening brain, enriching qi and invigorating blood, and removing blood stasis. After using the medicine, the content of serum cholesterin and triglyceride obviously decreases, the content of high density lipoprotein and superoxide dismutases increases, the content of plasm LPO decreases and the effect of blood fat reducing and free radical clearing is obvious. In addition, the medicine has the remarkable efficacies of expanding brain blood vessel and increasing brain blood flow volume.

The invention discloses lactic acid bacteria for producing bile salt hydrolase as well as a screening method and application thereof, belonging to the technical field of food biology. In the invention, an improved qualitative analysis and quantitative analysis combined method can be used for accurately screening a bile salt hydrolase bacterial strain in high efficiency; the method disclosed by the invention is used for screening a plant lactic acid bacterium strain with higher activity of bile salt hydrolase; and the bacterial strain and the bile salt hydrolase produced by the bacterial strain can be applied to the field of foods and can be used for reducing the content of cholesterol of human serum.

The invention relates to a manufacturing method of lentinus edodes stem sweet potato residue oat flaky pastries. According to the manufacturing method, sweet potato residues are rinsed by water, a filter screen is used for filtering and draining, lentinus edodes stems are cleaned, dried and pulverized, oatmeal, berry sugar, brown sugar and shredded coconut stuffing are taken, low-gluten flour, the sweet potato residues, the lentinus edodes stems and baking soda are added, the full mixing is carried out, then, the mixed materials are added into corn syrup and butter for uniform stirring to become drier paste, a small block of paste is pinched into a ball shape, flattening, baking and cooling are carried out, and the lentinus edodes stem sweet potato residue oat flaky pastries are obtained. The manufacturing method has the advantages that the lentinus edodes stems and the sweet potato residues with high dietary fiber content are used as raw materials, the sweet potato residues and the lentinus edodes stems are reused, the environment pollution is reduced, and economy is realized; total dietary fibers and soluble dietary fibers of products are high; on the basis of maintaining the color, the fragrance and the taste of the original oat flaky pastries, vitamins, nicotinic acid, folic acid, protein, mineral elements and the like are added, and the oat flaky pastries can be used as food for loosing the weight and regulating the blood sugar, the blood pressure and the serum cholesterol; and the forming effect is good, the eating is safe, the process is simple, the continuity is good, the operation cost is low, the generated waste materials are few, and the environment cannot be polluted.