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Preparation of wild cactus polysaccharide extract and high-efficient serum cholesterol-reducing function

The technology of cactus polysaccharide and extract is applied in the field of wild cactus polysaccharide extract and its action mechanism of lowering serum cholesterol, which can solve the problems of large side effects and poor curative effect, and achieve the effects of clear curative effect, convenient material extraction and simple extraction process.

Inactive Publication Date: 2009-07-08
ZHANJIANG NORMAL UNIV
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Problems solved by technology

[0005] In order to overcome the disadvantages of existing chemical medicines such as large side effects and poor curative effect, the present invention provides a polysaccharide extracted from the natural plant wild cactus, and it is found that the polysaccharide has a good effect of reducing serum total cholesterol content and improving lipid metabolism disorder effect, no obvious adverse reactions

Method used

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  • Preparation of wild cactus polysaccharide extract and high-efficient serum cholesterol-reducing function
  • Preparation of wild cactus polysaccharide extract and high-efficient serum cholesterol-reducing function
  • Preparation of wild cactus polysaccharide extract and high-efficient serum cholesterol-reducing function

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Embodiment

[0044] A. Extraction of cactus water-soluble polysaccharides: take fresh cactus, remove thorns and peel off, wash with water, chop, homogenate, soak 5 times with 80% ethanol at room temperature for 12 hours, remove fat-soluble substances and residues Dry at 80°C, pulverize, and pass through a 200-mesh sieve to obtain cactus powder. Take a certain amount of cactus powder (solid-liquid ratio 1:30) and add 1000mL distilled water, homogenate, add 0.7% pectinase, temperature 40°C, pH 3.5, extract for 1.5h, centrifuge, combine supernatants, and concentrate under reduced pressure. Add 4 times the volume of 95% ethanol (pre-cooled at 4°C) and let it stand for 12 hours to produce a large amount of white precipitate, which is collected by centrifugation and dissolved in distilled water. Concentrate to about 1 / 2 of the volume of the stock solution, freeze-thaw and centrifuge five times at -20°C to room temperature to remove protein. Distilled water dialysis (molecular weight cut-off: 35...

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Abstract

The invention relates to the preparation of a wild cactus polyoses extract and the highly effective function thereof for reducing serum cholesterase. The extract is a polyoses extracted from the natural wild cactus polyoses, and can reduce the total cholesterol content in the hypercholesterolemia and obviously improve the lipid metabolic disturbance by improving the activity of in vivo lipid metabolic key enzyme lecithin cholesterin acylase and reducing the activity of synthetical rate-limiting enzyme 3-hydroxy-3-methyl pentane diacid coenzyme A reductase of liver cholesterin; the invention has no obviouse adverse reaction and can be used for preparing medicines used for lowering the cholesterin.

Description

technical field [0001] The invention relates to the preparation of a wild cactus polysaccharide extract and its high-efficiency lowering effect on serum cholesterol, in particular to a wild cactus polysaccharide extract capable of significantly reducing serum total cholesterol in hyperlipidemia and its action mechanism for lowering serum cholesterol. Background technique [0002] According to the results of the 2002 Chinese Resident Health and Nutrition Survey, the number of people with hyperlipidemia in China has reached 160 million, among which high cholesterol is the most harmful. The current treatment for hypercholesterolemia is divided into two phases: lifestyle changes and drug treatment. [0003] Lifestyle changes include dietary therapy, increased physical activity, smoking cessation, elimination of excessive mental stress, and weight loss in overweight individuals. After diet therapy and other lifestyle improvements, if the patient still has dyslipidemia, drug trea...

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Application Information

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IPC IPC(8): A61K36/33A61P3/06A61K135/00
Inventor 曾富华陶美华杨小舟兰琦杰黄卫张松莲
Owner ZHANJIANG NORMAL UNIV
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