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Papaya extract, as well as preparation method and use thereof

A kind of papaya extract and technology of papaya, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems that have not been reported, and achieve the effect of preventing and treating liver fibrosis and high purification efficiency

Active Publication Date: 2014-03-19
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the prior art mentions that papaya has the function of protecting the liver, the prior art only generally mentions the above-mentioned effect, and does not mention that papaya extract has an inhibitory effect on the specific pathological process of liver fibrosis. Does papaya extract have therapeutic effect? The role of liver fibrosis has not been reported in the prior art

Method used

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  • Papaya extract, as well as preparation method and use thereof
  • Papaya extract, as well as preparation method and use thereof
  • Papaya extract, as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: the preparation of papaya extract

[0070] The implementation steps of this embodiment are as follows:

[0071] A. Papaya Extract

[0072] Grind the papaya raw material, according to the weight ratio of papaya and ethanol aqueous solution 1:8, soak the crushed papaya in 80% ethanol aqueous solution for 4 hours, then heat and reflux for extraction twice, each time for 4 hours, combine the extracts, and then Concentrate under reduced pressure at a pressure of 0.001 MPa and room temperature until the extract has no alcohol smell, and obtain a concentrated solution;

[0073] B. Extraction and separation

[0074] The concentrated solution obtained in step A was mixed according to the ratio of the concentrated solution and petroleum ether in a volume ratio of 1:3, subjected to multiple extractions and two-phase separation, until the petroleum ether layer was colorless, the petroleum ether layer was discarded, and the water layer was combined; Then the combine...

Embodiment 2

[0077] Embodiment 2: the preparation of papaya extract

[0078] The implementation steps of this embodiment are as follows:

[0079] A. Papaya Extract

[0080] Grind the papaya raw material, according to the weight ratio of papaya and ethanol aqueous solution 1:5, soak the crushed papaya in 90% ethanol aqueous solution for 3 hours, then heat and reflux for extraction twice, each time for 1 hour, combine the extracts, and then Concentrate under reduced pressure at a pressure of 0.008 MPa and room temperature until the extract has no alcohol smell, and a concentrated solution is obtained;

[0081] B. Extraction and separation

[0082] The concentrated solution obtained in step A was mixed according to the ratio of the concentrated solution and petroleum ether in a volume ratio of 1:4, and multiple extractions and two-phase separation were performed until the petroleum ether layer was colorless, the petroleum ether layer was discarded, and the water layer was combined; Then th...

Embodiment 3

[0085] Embodiment 3: the preparation of papaya extract

[0086] The implementation steps of this embodiment are as follows:

[0087] A. Papaya Extract

[0088] Grind the papaya raw material, according to the weight ratio of papaya and ethanol aqueous solution 1:12, soak the crushed papaya in 75% ethanol aqueous solution for 5 hours, then heat and reflux for extraction 4 times, each time for 3 hours, combine the extracts, and then Concentrate under reduced pressure at a pressure of 0.01 MPa and room temperature until the extract has no alcohol smell, and obtain a concentrated solution;

[0089] B. Extraction and separation

[0090]The concentrated solution obtained in step A was mixed according to the ratio of the concentrated solution and petroleum ether in a volume ratio of 1:1, subjected to multiple extractions and two-phase separation, until the petroleum ether layer was colorless, the petroleum ether layer was discarded, and the water layer was combined; The combined aq...

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Abstract

The invention relates to a preparation method for papaya extract and the novel use of the papaya extract for the treatment of hepatic fibrosis. The preparation method comprises the steps of papaya extraction, extraction separation, resin adsorption and the like. According to the preparation method and the use, a high-fat diet molding technology is used for making researches on the use and effects of the papaya extract in an animal body, and experimental results show that the papaya extract has high liver protection and lipid lowering activity and good curative effects on hepatic fibrosis and can remarkably inhibit hepatic fibrosis.

Description

【Technical field】 [0001] The invention belongs to the technical field of traditional Chinese medicine application. More specifically, the present invention relates to an extract of papaya, a preparation method of the extract of papaya, and an application of the extract of papaya. 【Background technique】 [0002] Liver fibrosis refers to the pathological process of abnormal proliferation of connective tissue in the liver caused by various pathogenic factors, leading to excessive precipitation of diffuse extracellular matrix in the liver. It is not an independent disease, but a specific pathological development stage , Many chronic liver diseases can cause liver fibrosis. Hepatic fibrosis is mainly characterized by hepatic sinusoidal capillaryization and hepatic lobular and portal area fibrosis. Various chronic liver injuries can lead to excessive proliferation and abnormal deposition of extracellular matrix components in the liver, resulting in abnormal liver structure or (an...

Claims

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Application Information

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IPC IPC(8): A61K36/732A61P1/16
Inventor 袁丁张长城刘朝奇王婷孙志伟周志勇崔倩倩万静枝何毓敏
Owner CHINA THREE GORGES UNIV
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