Metabolic pathway of moringa oleifera seed antidiabetic serum potential markers based on metabonomics and research method

Abstract

The invention discloses a metabolic pathway of moringa oleifera seed antidiabetic serum potential markers based on metabonomics and a research method, relates to a research method of an action mechanism of natural vegetable drugs, and aims to solve the problem that the action mechanism of the natural vegetable drugs cannot be systematically and comprehensively evaluated by a conventional single pharmacological method. The metabolic pathway is realized through the following steps of: (1) detecting and analyzing serum metabolism products of rats suffering from diabetes induced through high-sugarhigh-fat diet and low-dosage streptozotocin and serum metabolism products of the rats after intervention with moringa oleifera seeds, through a nuclear magnetic resonance technique; (2) screening out14 moringa oleifera seed antidiabetic relevant serum potential markers and performing identification; and (3) screening out 5 moringa oleifera seed antidiabetic metabolic pathways and performing analysis. According to the metabolic pathway disclosed by the invention, the action mechanism of the moringa oleifera seeds for resisting diabetes can be evaluated comprehensively, efficiently, quickly and synthetically without bias from the integral level, and a basis is provided for clarification and further development of the action mechanism of the natural vegetable drugs for resisting diabetes.

Description

technical field [0001] The invention belongs to the field of medicine. Specifically, it is a metabolomics-based metabolic pathway and research method of anti-diabetic serum potential markers of Moringa oleifera seeds. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia, and has become the third major chronic disease that seriously endangers human health. The resulting cardiovascular and microvascular complications have become the main cause of death and disability. There is a cure. The prevalence of type 2 diabetes and its complications, disability and mortality rate rank first in the world in China, and the huge population of patients has caused a huge economic burden to the family and society. Therefore, it is of great significance and urgency to find drugs that can prevent and intervene in the pathogenesis of type 2 diabetes and to clarify its mechanism of action for improving the health of our people. [0003] For a l...

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Problems solved by technology

[0007] The purpose of the present invention is to address the difficulty that the existing pharmacological methods cannot completely and comprehensively explain the anti-diabetic mechanism of Moringa oleifera seed, and to provide a metabolomics-based metabolic pathway and research method for anti-diabetic serum potential markers of Moringa oleifera seed , to provide a basis for the further development and utilization of Moringa seeds

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