Application of ampelopsin in preparing medicines for treating obesity

Abstract

The invention discloses application of ampelopsin in preparing medicines for treating obesity, and relates to preparation and application of flavonoids compounds. The ampelopsin is used for preparing medicines or health products for treating the obesity, including oral tablets, capsules, granules, oral solution, sustained-release agents, pills and injection solution for treating the obesity, and pharmaceutically acceptable conventional formulations. The ampelopsin has obvious weight-losing effect on obese mice and overweight mice induced by high-fat diet; after the ampelopsin is poured into stomachs of the obese mice in a dose of 25.0mg / kg for 2 weeks, the abdominal fat is obviously reduced, shoulder fat cells are obviously shrunk, the weight is reduced to be normal, and the mice are generally good in conditions, freely acts and have smooth hairs. The maximum tolerance does of the mice through stomach perfusion can reach 18g / kg.

Description

technical field [0001] The invention belongs to the preparation and application of flavonoids, in particular to the application of staphylophyllin in treating obesity. Background technique [0002] Obesity is an unhealthy state of body fat accumulation and weight gain due to calorie intake exceeding consumption. The incidence of obesity is increasing rapidly in both developed countries and developing countries, and it is showing a trend of younger age. It has become a global epidemic that seriously affects health [Xu Manyin, editor-in-chief. Diabetology. Shanghai Science and Technology Press. 2010, Second Edition, p121], at present, there are at least 200-300 million overweight people in my country, and over 70 million people with obesity [Chen Xiuqing. Obesity and its drug treatment. Chinese Medicine Guide. 2010; 32(8): 36- 37]. [0003] Obesity not only affects people's daily life, but also is the main factor leading to diseases such as type 2 diabetes, coronary heart dise...

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Problems solved by technology

Modern experimental studies have shown that staphylophyllin has various pharmacological activities such as antibacterial and anti-inflammatory, anti-oxidation, anti-tumor, liver protection and hypoglycemic [Li Cuiping, Cao Shuwen, Yu Yanying. Research progress of dihydromyricetin[J]. Chemical Reagent. 2010, 32 (7): 608~ 612. Yang Xuemin, Chen Lifeng. Research progress on the biological activity of dihydromyricetin [J]. Chinese Medicine Herald. 2008,14(12):86-89. Yang Zhenhuai, Guo Jiewen, Pan Jingqiang, Li Guanning. Snake Grape Studies on the pharmacological effects of plants of the genus anti-tumor, anti-oxidation, liver protection and blood lipid regulation [J]. Chinese Medicine Research. 2004, 17(4): 57-58], but there is no report that it can be used to treat obesity

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