Application of 2, 3-indolequinone in preparation of medicine for treating or preventing atherosclerotic cardiovascular and cerebrovascular diseases

A technology for atherosclerosis, cardiovascular and cerebrovascular diseases, applied in the field of medicine

Inactive Publication Date: 2020-09-15
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, no indole-2,3-dione has been used in the prevention or treatment of atherosclerosis

Method used

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  • Application of 2, 3-indolequinone in preparation of medicine for treating or preventing atherosclerotic cardiovascular and cerebrovascular diseases
  • Application of 2, 3-indolequinone in preparation of medicine for treating or preventing atherosclerotic cardiovascular and cerebrovascular diseases
  • Application of 2, 3-indolequinone in preparation of medicine for treating or preventing atherosclerotic cardiovascular and cerebrovascular diseases

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Embodiment Construction

[0042] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, so that those skilled in the art can better understand the present invention, but the present invention is not limited thereto.

[0043] Pharmacological experimental data of 3-indolequinone in the treatment of atherosclerosis.

[0044] Which animal to choose as an AS animal model needs to be considered from the following points: (1) The physiological structure is similar to the human body, and it has the expected effect on drug treatment or other interventions; (2) The animal is easy to obtain and raise in large quantities, Appropriate size, short feeding cycle, strong reproductive ability, and low overall cost; (3) The animal model has good operability and repeatability, and is easy to obtain through food feeding or simple operations; (4) The animal model can maintain a stable AS state, to avoid repetition; (5) The AS plaques generated are simil...

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Abstract

The invention belongs to the technical field of medicines, and relates to a new medical application of 2,3-indolequinone, and in particular relates to an application of 2,3-indolequinone in preparation of a medicine for treating or preventing atherosclerotic cardiovascular and cerebrovascular diseases. Pharmacological experiment results show that the 2,3-indolequinone can significantly improve atherosclerosis injury of apoE- / -mice. The 2,3-indolequinone can reduce the content of macrophages in atherosclerotic plaques, the content of smooth muscle cells is increased, the lipid content is reduced, and the plaque stability is obviously improved.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a new medical application of 2,3-indolequinone, in particular to the application of 2,3-indolequinone in the preparation of drugs for treating or preventing atherosclerosis. Background technique [0002] Epidemiological statistics show that the death and disability rate of cardiovascular and cerebrovascular diseases ranks first among various diseases in the world. It not only brings great harm to human health and life, but also greatly increases the burden on society and families. Atherosclerotic (AS) cardiovascular and cerebrovascular diseases and acute cardiovascular and cerebrovascular events caused by AS plaque rupture are the primary pathological causes of death and disability in patients with cardiovascular and cerebrovascular diseases. The main pathological features of AS include chronic inflammation, oxidative stress, and lipid accumulation in the walls of large and medium ...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P9/10
CPCA61K31/404A61P9/10
Inventor 张继国于杨王慧云李秀娟
Owner SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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