544results about How to "Strong medicine" patented technology

Medical systems and methods for treating kidney disease alone, heart failure alone, kidney disease with concomitant heart failure, or cardiorenal syndrome are described. The systems and methods are based on delivery of a chimeric natriuretic peptide to a patient. Methods for increasing peptide levels include direct peptide delivery via either an external or implantable programmable pump.

The invention relates to a medical used hot melt pressure-sensitive adhesive type base material and its preparing method which provides a hot melt pressure-sensitive adhesive and an adhesive used paste preparation. The main element of the hot melt pressure-sensitive adhesive is styrenic thermoplastic elastomer SIS (phenylethene -isoprene -phenylethene three block copolymers) with adhesive resin (such as petroleum resin, terpenes polymer, polyisobutylene), flexing oil (such as liquid petrolatum) and aging retarder (such as propyl gallate, BZ) and so on.

The invention discloses an ecological pesticide-added fertilizer scientifically prepared from minerals and organic fertilizers as fertilizer efficiency ingredients and Chinese herbal medicines as pest-killing and pest-dispelling ingredients, and a preparation method of the ecological pesticide-added fertilizer, belonging to the field of fertilizers. The ecological pesticide-added fertilizer is prepared from the following raw materials by weight parts: 6-50 parts of the organic fertilizers, 6.5-65 parts of crude salt, 3.5-35 parts of lime, 2-25 parts of atropa belladonna, 2-15 parts of poinsettia, 2-25 parts of alocasia macrorrhiza, 2-15 parts of rohdea japonica, 2-25 parts of flos daturae, 2-20 parts of chili and 2-25 parts of garlic. The ecological pesticide-added fertilizer has the characteristics of being safe, environment-friendly and free of toxic side effects, pesticide and fertilizer effects are integrated, the environment can not be polluted, the human health can not be threatened, a production process is simple, the material source is wide, and the pesticide effect and the fertility are good.

The invention relates, inter alia, to a method for reducing symptoms of, or for treating, one or more disorders or conditions wherein the dopaminergic system is disrupted, the method comprising administering to a host in need thereof an effective amount of a compound that is able to increase the ion flow through KCNQ potassium channels.

The invention discloses a drill pipe device for mixed injection of various medicaments. The drill pipe device comprises an outer pipe, an inner pipe and a drill bit. Both the outer pipe and the inner pipe are of hollow structure and sleeved together, and a gap between the outer pipe and the inner pipe forms a first cavity. The upper portion of the outer pipe is provided with a first medicament connecting hole which is communicated with the first cavity. The inner wall of the bottom of the outer pipe is provided with a step, and the first cavity is closed by the step and the outer wall of the inner pipe together. The upper portion of the inner pipe is provided with a second medicament connecting hole which is communicated with a cavity of the inner pipe. The drill bit is connected with the outer pipe, and a second cavity is formed inside the drill bit and is communicated with the cavity of the inner pipe. Jet holes communicated with the outside are respectively formed in the side walls of the first cavity and the second cavity. The drill pipe device for injection in situ of soil and underground water realizes underground mixing of various medicaments, reduces interaction consumption before the medicaments contact with pollutants, and improves effect of in-situ repair.

The invention relates to a DSPE-PEG2000-FA-modified nanometer paclitaxel liposome. A molar ratio of the DSPE-PEG2000-FA to egg yolk lecithin is 0.05% to 0.15%, and a particle size of the liposome is less than 150 nm. A preparation method of the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome comprises the following steps: first, preparing a DSPE-PEG2000-FA into a DSPE-PEG2000-FA micelle; second, performing incubation on the phosphatidyl ethanolamine-polyethylene glycol2000-folic acid micelle and a paclitaxel liposome together to obtain a DSPE-PEG2000-FA-modified nanometer paclitaxel liposome. Materials, which are forbidden to be used in clinical practice, are not used as crude materials in the present invention. According to the invention, the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome has a small particle size, and the content of the DSPE-PEG2000-FA is low; besides, the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome has good drug entrapment efficiency and good colloid stability. Moreover, the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome can be absorbed effectively by an ovarian cancer cell having properties of sensitiveness to folic acid (+) and drug resistance, and the cytotoxicity of folic acid dependence is displayed; therefore, the efficacy of the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome is stronger than that of a paclitaxel injection.

The present invention relates to externally applied medicine for treating mastopathy. The medicine includes two componnets. The component A is prepared with over 20 kinds of Chinese medicinal materials including angelica, trogopterus dung, sea algae, bupleurum root, corydalis tuber, etc.; and the component A is prepared with dahurian angelica root, nutagrass flatsedge rhizome, frankincense, myrrh, rhubarb and other Chinese medicinal materials. The medicine is applied directly to the pathologic parts to take effect, so that it has fast effect and no influence on digestive system and internal secretion system.

The invention discloses a Chinese medicinal composition for treating dermatosis. The Chinese medicinal composition comprises an oral part and an external part, wherein the oral part is prepared from the following 18 Chinese herbal medicine raw materials in part by weight: 6 to 9 parts of honeysuckle flower, 6 to 9 parts of wild chrysanthemum, 6 to 9 parts of amur corktree bark, 6 to 9 parts of lightyellow sophora root, 6 to 9 parts of sweet wormwood herb, 6 to 9 parts of glabrous greenbrier rhizome, 6 to 9 parts of Szechuan lovage rhizome and the like; and the external part is prepared from the following 18 Chinese herbal medicine raw materials in part by weight: 6 to 9 parts of common threewingnut root, 6 parts of candlenut, 6 to 9 parts of golden larch bark, 6 to 9 parts of sapium sebiferum bark, 6 to 9 parts of jequirity, 6 to 9 parts of cortex meliae, 6 to 9 parts of Chinese gall, 6 to 9 parts of gelsemium elegans benth and the like. The Chinese medicinal compound has the effects of clearing heat and detoxicating, killing worms and relieving itching, dispelling pathogenic wind and removing dampness, cooling blood and activating blood, discharging filth and drawing out pus and the like, and has the advantages of unique formula, low dose, quick response, short treatment course, capability of being used for various skin diseases except burn and over 95 percent of effective rate for treating various skin diseases by clinical verification.

The invention discloses a hormone-free rapid tissue culture and propagation method of Emei roxburgh anoectochilus terminal bud seeds. According to the hormone-free rapid tissue culture and propagation method, no hormone is used in the whole process, the mature and non-cracking fruits, which is pollinated for 5 months after flowering, of wild or artificially planted roxburgh anoectochilus terminal bud distributed in Szechuan Emei region are taken as the material, and seedlings are bred efficiently and quickly according to the route from seeds to protocorms, complete plants and acclimatization and transplant. A hormone-free culture medium is adopted in the whole process; more than 5000 good-quality seedlings can be quickly bred from one mature fruit by virtue of tissue culture of about 10-12 months, and after acclimatization and transplant, the greenhouse culture survival rate can be above 95%. According to The hormone-free rapid tissue culture and propagation method of the Emei roxburgh anoectochilus terminal bud seeds is capable of keeping the good traits of the Emei roxburgh anoectochilus terminal bud and maintaining the good medicinal properties of the Emei roxburgh anoectochilus terminal bud; besides, the method is simple, and the cost is low; industrialized seedling production can be realized; no hormone is adopted so that the safety of the seedlings can be ensured; the hormone-free rapid tissue culture and propagation method has important significance on regeneration and sustainable utilization of critically endangered valuable and rare resources of medicinal plants and protection of seed resources.

The invention relates to a gel injection combining a molecular targeted drug and a cytotoxic drug. The gel injection comprises a small molecular targeted drug, a traditional cytotoxic drug, a temperature-sensitive material, a solvent and pharmaceutical excipients, wherein the temperature-sensitive material is selected from poloxamer, polylacticacid-polyethylene glycol-polylactic acid or polyglycolide lactide-polyethylene glycol-polyglycolide lactide and the like; the solvent is selected from water, brine salt or 5% glucose aqueous solution and the like, the prepared gel injection can be injected intratumorally or peritumorally, the anti-tumor effect is obvious, and the side effects are fewer.

The invention relates to a salve for the treatment of traumatism, contusion, alopecia areata as well as burn and scald, essentially solving the problems that drugs for curing traumatism, contusion, alopecia areata as well as burn and scald have single function, poor curative effects, easy wound infection and scars at the wound after recovery. The salve is characterized in that the salve is prepared by drugs according to the following weight ratio: 3 portions to 5 portions of calomeas, 8 portions to 10 portions of realgar, 8 portions to 12 portions of calamine, 5 portions to 9 portions of boswellia carteri, 5 portions to 9 portions of myrrh, 3 portions to 4 portions of borneol, 8 portions to 12 portions of resina draconis, 5 portions to 9 portions of catechu and 180 portions to 280 portions of vasogen for medical purposes. The salve has the effects of diminishing inflammation and detoxication, removing slough, heeling wounds, invigorating the circulation of qi and blood, reducing swelling and easing pain, disinfesting insects and eliminating toxic materials, promoting blood circulation and removing blood stasis, removing toxic substance and evacuating pus, promoting reunion of the fractured bones, promoting hair growth, repairing wound, promoting regeneration of skin and quickening tissue regeneration.

The invention discloses a blank liposome taking ginsenoside Rg3 or an analogue thereof as a membrane material, and a preparation method and application thereof. The ginsenoside as shown in the formulaI is blank liposome of a membrane material, wherein the blank liposome is provided with a membrane, and the membrane comprises lipid substances and the ginsenoside as shown in the formula I. The blank liposome disclosed by the invention has the characteristics of good film-forming property, encapsulation efficiency, targeting property, long circulation, stability, safety and uniformity, is used for encapsulating active substances, biological agents, polynucleotides or oligonucleotides in medicines and cosmetics to form the liposome loaded with the active substances, and is simple and convenient in preparation process.

The invention discloses a production technology of herba dendrobii scented tea, relating to the field of food processing. The production technology comprises the following steps: picking, carrying out first drying, scenting, performing firing in refinement processing, removing mixed color and packaging, sorting blossoms and partially opening buds by adopting a manual sorting picking method. The herba dendrobii flowers are obvious in effects and the strongest medical effect can be guaranteed. The optimal medical effect of the herba dendrobii scented tea can be achieved after the herba dendrobii scented tea is treated by the following steps: carrying out primary drying and first drying, roasting and drying and firing in refinement processing during refining and then removing mixed color, and finally packaging the herba dendrobii scented tea. The herba dendrobii scented tea is suitable for symptoms such as psychanopsia, restlessness, high working pressure and the like.

The Chinese medicine composition for curing rheumatic and rheumatoid arthritis comprises 17 Chinese medicinal materials of Chinese angelica root, black-striped snake, scorpion, gastrodia tuber, chaenomeles fruit, achyranthes root and others as raw material.

The invention discloses a tissue culture rapid propagation method of anoectochilus formosanus, and belongs to the technical field of plant tissue culture. By adopting the tissue culture rapid propagation method, the survival rate of transplanting and the growth coefficient can be increased, and the good characters and the good drug properties of the Emei anoectochilus formosanus can be kept. The tissue culture rapid propagation method comprises the following steps: selecting wild Emei anoectochilus formosanus growing in May to October, preparing an explant, carrying out disinfection treatment, inducing cluster buds, carrying out secondary culture and rooting and strengthening culture, and transplanting to greenhouses for culturing, and rapidly propagating the anoectochilus formosanus through hormone induction. The tissue culture rapid propagation method can be used for ensuring the good characters and the good drug properties of the Emei anoectochilus formosanus, is simple and low in cost and can realize industrialized seedling production. The percentage of inducing the cluster buds and rooting by adopting the method reaches above 90%, the survival rate of transplanting is above 95%, and the growth coefficients within four months can reach 8-10 times. The Emei anoectochilus formosanus produced by adopting the method does not mutate, is high in yield, low in cost and short in period and has relatively strong market competitiveness.

The invention discloses compound low-concentration atropine eye drops and a preparation method thereof. The eye drops are mainly prepared from low-concentration atropine, lutein or a lutein derivative, fructus lycii, taurine, liquid pearl and multiple vitamins (A, B1, B6, B12 and E) by processing in a certain ratio. Drugs used in the compound eye drops conform to Chinese pharmacopoeia and United States Pharmacopeia, by means of functional collaborative treatment synergy of various natural drug active factors and atropine for vision, dose of atropine is reduced effectively, side effects on human eyes are reduced, ciliary muscle spasm can be eliminated, eyeball nutrition can be improved, asthenopia can be relieved, the eye drops have effects of improving eyesight and clearing away heat and toxic materials and have the capacity of enhancing human eye immunity and resisting eye diseases, the effect of preventing and treating myopia of adolescents and children is enhanced effectively, and the eye drops are high in safety, long in shelf life and good in biocompatibility with eye environment and has positive promotion and application values.

The invention discloses an ultrasonic controlled release medicine elution balloon catheter and a preparation method. The surface of the medicine elution balloon catheter is coated with a medicine coating, the medicine coating is composed of a fat-soluble medicine carrying microcapsule having a ultrasonic response characteristic and an adhesive having a water-soluble characteristic. Medicine of the medicine elution balloon catheter is wrapped in a lipophilic medicine carrying microcapsule which is hard to dissolve in the blood, so medicine loss caused by blood washing can be reduced. When the ultrasonic controlled release medicine elution balloon catheter is used, the medicine elution balloon catheter is sent to a lesion portion and unfolds, a balloon contacts with the lesion tissues, ultrasound inducts the lesion portion at the external, the medicine carrying microcapsule can be speeded up to be separated from the hydrophilic adhesive, medicine can diffuse in the fat-soluble lesion tissues, at the same time, the medicine carrying microcapsule having the ultrasonic response characteristic breaks under the function of the ultrasound and discharges the medicine, the efficiency of medicine absorption and utilization by the target lesion tissues can be greatly raised. The amount and time of medicine discharge can be controlled through adjusting the characteristic and the ultrasonic characteristic of the medicine carrying microcapsule, the validity and safety of the medicine elution balloon catheter can be improved.

The invention relates to an externally-applied plaster with the functions of detoxifying and promoting tissue regeneration. In the invention, angelica, dahurian angelica root, radix arnebiae seu lithospermi, astragalus root, radix salviae miltiorrhizae and sward are put into sesame oil and soaked, the sesame oil is heated to cause the traditional Chinese medicines in the sesame oil to be burnt into carbon, medicine residues are filtered out, mercurous chloride, red lead, mastic, myrrh and draconis sanguis are sequentially added into the sesame oil, the sesame oil is stirred and heated until the sesame oil does not fume any longer, centipede and scorpio are added into the sesame oil after the sesame oil is cooled, and then the sesame oil is evenly stirred to prepare the externally-applied plaster. The medicine is mainly used for treating diseases, such as various ulcers, purulent ulcers, bedsores, no concrescence of wounds for a long time after operation and the like, has the functions of resisting bacteria, diminishing inflammation, decreasing swelling, alleviating pain, promoting blood circulation, relieving the stasis of blood and reinforcing the bacteriostasis and sterilization capabilities of wound faces, improves the microcirculation of ulcer positions, induces the exudation of the nutritive tissue liquid of organisms, restores the effective ingredients of organism tissues and has the effects of removing putrescence, promoting tissue generation, eliminating putrescence and promoting tissue regeneration. By clinical observation, the total effective rate reaches 95%.

The invention relates to the field of drugs, in particular to a preparation method of a sustained release preparation containing ibuprofen mini-pills. The technical problem to be solved is to provide the sustained release preparation containing ibuprofen mini-pills. A relative substance detection method is added for the medicament by our company by reference to the British Pharmacopoeia. The medical property of the medicament is released stably and lastingly, and the safety and effectiveness of the medicament are really achieved. The adopted technical is as follows: weighing the following raw materials in parts by weight: 25-35 parts of ibuprofen, 3-10 parts of milk sugar, 1-5 parts of microcrystalline cellulose, 1-5 parts of hydroxypropyl methylcellulose and 10-15 parts of medicinal ethanol; then mixing the materials and spraying an adhesive into the materials to obtain the ibuprofen sustained release preparation. The preparation method of the sustained release preparation containing ibuprofen mini-pills is widely applied to the pharmaceutical field of the ibuprofen.

The invention discloses a medicament for treating empyrosis, which comprises the following components in part by weight: 10 to15 parts of white chrysanthemum flower, 10 to 12 parts of pinellia tuber, 500 parts of calcined lime, 10 to 15 parts of borneol, 5 to 10 parts of rhubarb, 5 to 10 parts of lightyellow sophora root, 5 to 10 parts of amur corktree bark, 5 to 10 parts of catechu, 11 to 14 parts of golden thread, 10 to 15 parts of swordlike atractylodes rhizome, 60 to 100 parts of calcined calamine and 15 to 30 parts of garden burnet root. The components are crushed, mixed, sealed and buried underground for preserving for three years. In the medicament, the components are subjected to organic compatibility, and have the complementary effect to bring the optimal synergistic effect into play, so that the medicament has powerful medicinal effects of diminishing inflammation and reliving pain quickly, removing nidus of organisms effectively, and achieving an unexpected treatment effect.

A composite anticoccidial medicine for fowls is prepared from antifebrile dichroa root, bupleurum root, flavescent sophora root and sweet wormwood through cutting short, immersing in water, decocting three times while filtering, depositing in alcohol, filtering and sterilizing.

The invention belongs to the field of feeds for quails and particularly relates to Chinese-herbal-medicine feed for quails. The Chinese-herbal-medicine feed is characterized by comprising the following components in parts by weight: 40-60 parts of corn, 20-30 parts of soybean meal, 5-10 parts of super fish powder, 2-4 parts of soybean oil, 2-6 parts of grass seed powder, 5-10 parts of soybean oil cake residue, 5-10 parts of rice bran, 1-3 parts of salt, 10-15 parts of premix and 10-15 parts of traditional-Chinese-medicine additives. The Chinese-herbal-medicine feed has the beneficial effects that materials such as the corn, the bean meal and the grass seed powder with suitability for intaking of the quails, high digestibility and good palatability are selected according to the nutrition needed by growth and development of the laying quails, the nutrition is rich, the protein content is high, the energy is high, the nutrition needed by the laying quails is provided, the materials are easily digested and absorbed by the quails, the daily feed intake is increased and the egg laying capability is enhanced; a proper material matching ratio is determined by multiple testing, the most reasonable feed-egg ratio is ensured, and the raising income is largest; and the feed contains the components such as the premix and the traditional-Chinese-medicine additives, the types of nutritional elements are complete, and various nutritional components needed are provided, so that the healthy growth of the quails is ensured.

The invention provides chitosan-modified methazolamide solid lipid nanoparticles and a preparation method thereof. The chitosan-modified methazolamide solid lipid nanoparticles can be used as eye drops. The preparation method is suitable for industrial production. The chitosan-modified methazolamide solid lipid nanoparticles are characterized in that based on 30ml of a nanoparticle-containing solution, the chitosan-modified methazolamide solid lipid nanoparticles comprise 5mg of methazolamide, 25 to 150mg of at least one lipid material, 25 to 150mg of phospholipid, 5 to 100mg of chitosan, 50 to 250mg of at least one non-phospholipid surfactant and 50 to 250mg of at least one assistant surfactant. The chitosan-modified methazolamide solid lipid nanoparticles have small particle sizes and high drug entrapment efficiency. Compared with solid lipid nanoparticles which are not modified by chitosan, the chitosan-modified methazolamide solid lipid nanoparticles have higher stability and better corneal permeability because of positive charges on the surfaces of the chitosan-modified methazolamide solid lipid nanoparticles so that drug bioavailability is improved. Therefore, the chitosan-modified methazolamide solid lipid nanoparticles have a large clinical application potential in glaucoma treatment.

The invention relates to weight-reducing tea. The weight-reducing tea is mainly prepared from the following materials according to a certain weight ratio: lotus leaf, roselle calyx, lemon, sour orange, wild mint herb, ass-hide gelatin, lotus seeds, green tea, epigallo catechin gallate and xylooligosaccharide. The materials can be prepared into tea beverage, instant tea and teabag. The tea provided by the present invention has effects of qi promoting, body fluid regeneration, intestine moistening and bowel relaxing. The total effective rate of the tea for treating habitual constipations is more than 87%. In addition, the tea is easy to be drunk, and has significant treatment and health effects.

The invention relates to the technical field of planting, in particular to an efficient planting method for mulberry. The method comprises the following steps of seedling growing, transplanting, pest control and field management. By adopting the planting method, planted mulberry is high in disease resistance and insect resistance, high in yield and strong in pesticide effect, compared with the acre yield of mulberry planted through a traditional method, the yield of folium mori can be increased by 28% or above, the yield of mulberry fruits can be increased by 13.2% or above, and due to the planting method, the acre yield of mulberry trees is effectively improved; the survival rate of seedlings is increased by 9.4% compared with a traditional method; on the basis of the scientific planting method, effective components of mulberry trees can be effectively improved, the pesticide effect is improved, and the requirement of the current market for a large number of mulberry trees is met.

The invention discloses external application medicinal powder for treating lubar intervertebral disc protrusion, which consists of the following components by mass: 20 to 35g of szechuan lovage rhizome, 20 to 35g of Chinese angelica, 10 to 15g of peach seed, 10 to 15g of safflower, 10 to 15g of myrrh, 10 to 15g of trogopterus dung, 10 to 15g of liquoric root, 20 to 30g of incised notopterygium rhizome, 20 to 35g of largeleaf gentian root, 10 to 15g of nutgrass galingale rhizome, 10 to 15g of earthworm, 20 to 35g of twotooth achyranthes root, 10 to 15g of danshen root, 10 to 15g of common floweringquince fruit, 10 to 15g of eucommia bark, 30 to 45g of Chinese taxillus twig, 30 to 40g of clematis root, 10 to 15g of pangolin scales, 30 to 45g of black ant, 30 to 45g of williams elder twig and 10 to 15g of wild fagopyrum esculentum moench. The external application medicinal powder can invigorate blood circulation and promote flow of qi, remove pain, remove obstruction in channels, and free arthralgia to relieve pain, has the effects of insisting inflammation, easing pain and changing local tissue blood circulation, and achieves the effect of addressing both the symptoms and root causes.

The external medicine for treating traumatic injury with fast effect is prepared with eight kinds of Chinese medicinal materials including angelica, frankincense, myrrh, safflower, ledebouriella root, etc. as well as rosin and sesame oil. It has the functions of stopping pain, stopping itching, promoting blood circulation, elimianting blood clots, etc. It has high curative effect on tendon injury, sprain, fracture and other closed traumatic injury and has also certain curative effect on frostbite, scapulohumeral periarthritism tenosynovitis and hyperplasia of mammry glands.

The invention belongs to the field of traditional Chinese medicines or the pharmaceutical chemistry, and relates to a use of schisandrin B or a Chinese magnoliavine extract in the preparation of medicines for treating and / or adjunctively treating and / or preventing liver fibrosis or liver cirrhosis, medicines for treating or adjunctively treating diseases caused by the liver fibrosis or liver cirrhosis, or medicines for inhibiting liver stellate cell proliferation or DNA synthesis. The invention also relates to a method for inhibiting the liver stellate cell proliferation or inhibiting the liver stellate cell DNA synthesis in vitro / in vivo, and a medicinal composition containing the schisandrin B or the Chinese magnoliavine extract. It is proved that the schisandrin B can obviously improve the liver fibrosis or the liver cirrhosis degree, has no obvious hepatotoxicity and has a good application prospect.

The invention provides a pig breeding method with prevention of diseases, and relates to the technical field of breeding. The breeding method comprises the following steps of (1) raising management, (2) disease prevention and (3) pigsty hygiene management. According to the pig breeding method, through strict control over the pig breeding process, the quality of pigs is ensured; targeted phase raising is conducted in the raising management process, pig germs in vivo and vitro are strictly and effectively expelled in the disease prevention process, traditional Chinese medicine liquid is used for killing germs in the pigsty hygiene management process, and any medicine harmful to the pigs is not used in the whole process, which is green and ecological; while diseases are prevented and the growth of the pigs is accelerated, the quality of pork is ensured, the health of an eater is not influenced, and the method is worth popularization.

The invention relates to a chiral CB1 (cannabinoid) receptor inhibitor which is showed as a general formula A1 and a general formula A2 and has optical asymetery performance, and slat or solvate which is physiologically acceptable, in particular relates to a diaryl-replaced pyrazole ramification CB1 receptor inhibitor which is showed as the general formula A and the general formula B, has optical asymetery performance and is hypotoxic, and the method also discloses a preparation method and an application used for preparing medicaments for detoxification, weight losing, diabetes mellitus treatment or cardiovascular disease preventing, and all application on medical science related with the CB1 receptor inhibitor.