440 results about "Alopecia areata" patented technology

Substances, compositions and methods for hair treatment based on ultra-low molecular weight hyaluronic acid oligomers, possibly combined with trichogenic substances, useful for preventing hair loss and favouring its regrowth in subjects affected by androgenetic alopecia, alopecia areata, alopecia mucinosa and related disorders.

Traditional Chinese medicine for curing alopecia solves the problems of the existing medicines for curing alopecia, such as long period of treatment, long-term effect, single efficacy and high tendency towards relapsing. The traditional Chinese medicine of the invention includes medicaments for oral and external administration: the medicament for oral administration comprises the following components: prepared rhizome of rehmannia, Chinese angelica, hemlock parsley, baked bighead atractylodes rhizome, tuber fleeceflower stem, glossy privet fruit, common dodder, spatholobus stem, baked fleece-flower root, endothelium corneum gigeriae galli, Cornus officinalis sieb et zucc, herba epimedii, shizandra berry, tuckahoe, white peony root, root of red-rooted salvia, cacumen biotae, eclipta alba, niger seed, mulberry fruit, radix polygalae, fried wild jujube, cortex albiziae, notopterygium root, Radix Arnebiae seu Lithospermi, goldthread root, scutellaria baicalensis, peach kernel and raw liquorice root; and the medicaments for external administration comprises the following components: cacumen biotae, baked fleece-flower root, eclipta alba, pod pepper, drynaria baronii, green rhizomes, red flower, bark of tree peony root, root of red-rooted salvia, ginseng, hemlock parsley, lopseed, mulberry fruit, niger seed and borneol. The traditional Chinese medicine of the invention for curing alopecia has the advantages of short treatment period, instant effect, high efficiency and low tendency towards relapsing after treatment, and has good curative effects on alopecia areata, general alopecia, whole alopecia and seborrheic alopecia.

The present invention is directed to compositions and methods comprising the use of bimatoprost and cyclosporine, used concurrently and in combination, to grow hair and for the treatment of all types of hair loss conditions such as but not limited to alopecia areata. The present invention is also directed to compositions containing bimatoprost and cyclosporine A to grow hair on the scalp and other areas of the body and methods of administration of the compositions.

The invention relates to a gel composition containing tacrolimus, which contains the tacrolimus and ingredients of a matrix, wherein, the ingredients of the matrix contain one or more of liquid polyethylene glycol, glycerin and propylene glycol, the content of the tacrolimus in the gel is 0.01 percent to 0.5 percent, and the weight ratio of the tacrolimus to one or more of the liquid polyethylene glycol, the glycerin and the propylene glycol is 1: (50 to 3000). The invention further relates to a preparation method of the gel composition of the tacrolimus and the application of the gel composition in the preparation of drugs for the treatment of atopic dermatitis, vitiligo, psoriasis, hormone-dependent dermatitis, intractable neurodermatitis, lupus erythematosus, alopecia areata and other diseases.

Methods of using inhibitors of the CD2 / LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and irritant contact dermatitis, lichen planus, alopecia areata, pyoderma gangrenosum, vitiligo, ocular cicatricial pemphigoid, and urticaria.

Photodynamic therapy (PDT) is used to stimulate and / or restore hair growth in areas of hair loss. Methods and compositions relating to PDT treatment for alopecia are disclosed. In light of PDT use to remove unwanted hair by inactivating or destroying hair follicles or destroying the tissue feeding the hair follicles, such methods and compositions relate to a surprising and unexpected discovery. PDT permits a means to treat conditions relating to hair loss such as androgenic alopecia, alopecia areata and drug-induced alopecia.

The invention relates to a fungus tea drink, in particular to tea fungus and a culture method thereof. The tea fungus is prepared from black tea, green tea, scented tea, sugar, glucose, honey, medicine and water. The tea fungus can help digestion, cure various stomach diseases, contains microorganisms beneficial to a human body, can adjust the physiological functions of the human body, promote metabolism, help digestion, prevent arteriosclerosis, resist cancer, care health and strengthen the physique, and becomes a healthcare drink which is popular around the world. The tea fungus can cure various chronic diseases, such as hypertension, atherosclerosis, coronary heart disease, diabetes, constipation, hemorrhoids, obesity, alopecia areata, white hair, cataracts, rheumatoid arthritis, gastritis, diarrhea, anemia, riboflavin deficiency and the like.

Mixed vesicular system containing a nanoemulsion with bilayer nanovesicles mimicking noisome and liposome for the topical delivery of dithranol alone or together with salicylic acid to treat psoriasis, eczemas, dermatophytoses, alopecia areata and other dermatological diseases and methods for producing said system.

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a base anti-inflammatory agent, such as indometacin; one or more optional active ingredients selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol™, L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF-α) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.

The invention belongs to the field of Chinese materia medica preparations and relates to an anti-hair loss and hair growing traditional Chinese medicine composition and a preparation method of the anti-hair loss and hair growing traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 50-180 parts of ginseng, 50-180 parts of cacumen biotae, 20-120 parts of polygonum multiflorum, 10-70 parts of liquorice, 10-50 parts of old ginger, 50-180 parts of drynaria rhizome, 30-120 parts of eclipta alba, 5-50 parts of cordyceps sinensis and 20-80 parts of fructus ligustri lucidi. Products of the traditional Chinese medicine composition has characteristics of treating both symptoms and root causes, as well as various alopecias, and has the advantages of explicit therapeutic effects, wide treating faces, excellent effects on patents, rapid effect production, short course of treatment, high product safety and small toxic and side effects on human bodies. After checking, an effective rate of a prescription on sebrrheic alopecia can achieve 94.3%, and an effective rate of the prescription on alopecia areata can achieve 98%.

The invention provides a compound Chinese medicinal oral preparation for treating alopecia areata and alopecia and its preparing method, wherein the preparation comprises astragalus root, white atractylodes rhizome, arborviate seed, prepared fleece flower root, root of herbaceous peony, cherokee rose, Chinese angelica root, Ligusticum wallichii, eclipta, ligustrum japonicum, psoralea fruit, mulberry, root of red rooted saliva, black sesame seeds, dodder seed.

The invention discloses application of mesenchymal stem cell exosome to preparation of a drug preparation for promoting hair regeneration. Mesenchymal stem cells are prepared by the following method:separating and extracting the mesenchymal stem cells from an umbilical cord and then obtaining the mesenchymal stem cells through primary culture and subculture. The application of the mesenchymal stem cell exosome to preparation of the drug preparation for promoting the hair regeneration, disclosed by the invention, has the advantages that skin tissue structures on alopecia areata can be improvedby adopting the mesenchymal stem cell exosome, and hair follicles in the stationary phase in the skin tissue on the alopecia areata can be promoted to be transformed to a growing period; and the hairregeneration on the alopecia areata can be promoted. The application prospect of the mesenchymal stem cell exosome in preparation of the drug preparation for promoting the hair regeneration is broad.

The invention relates to a salve for the treatment of traumatism, contusion, alopecia areata as well as burn and scald, essentially solving the problems that drugs for curing traumatism, contusion, alopecia areata as well as burn and scald have single function, poor curative effects, easy wound infection and scars at the wound after recovery. The salve is characterized in that the salve is prepared by drugs according to the following weight ratio: 3 portions to 5 portions of calomeas, 8 portions to 10 portions of realgar, 8 portions to 12 portions of calamine, 5 portions to 9 portions of boswellia carteri, 5 portions to 9 portions of myrrh, 3 portions to 4 portions of borneol, 8 portions to 12 portions of resina draconis, 5 portions to 9 portions of catechu and 180 portions to 280 portions of vasogen for medical purposes. The salve has the effects of diminishing inflammation and detoxication, removing slough, heeling wounds, invigorating the circulation of qi and blood, reducing swelling and easing pain, disinfesting insects and eliminating toxic materials, promoting blood circulation and removing blood stasis, removing toxic substance and evacuating pus, promoting reunion of the fractured bones, promoting hair growth, repairing wound, promoting regeneration of skin and quickening tissue regeneration.

Photodynamic therapy (PDT) is used to stimulate and / or restore hair growth in areas of hair loss. Methods and compositions relating to PDT treatment for alopecia are disclosed. In light of PDT use to remove unwanted hair by inactivating or destroying hair follicles or destroying the tissue feeding the hair follicles, such methods and compositions relate to a surprising and unexpected discovery. PDT permits a means to treat conditions relating to hair loss such as androgenic alopecia, alopecia areata and drug-induced alopecia.

The invention discloses to an external Chinese medicinal composition for treating calvities and alopecia areata and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: tuber fleeceflower root, radix rehmanniae praeparata, borneol, camphor, mentha haplocalyx, cassia twig, angelica dahurlica, incised notopterygium rhizome, kudzuvine root, szechuan lovage rhizome, flos chrysanthemi, baical skullcap root, lightyellow sophora root, divaricate saposhnikovia root, weeping forsythia, red paeony root, white paeony root, peach seed, safflower, fineleaf schizonepeta herb, nutgrass galingale rhizome, notoginseng root and the like. The Chinese medicinal composition of the invention can be prepared into any external preparation according to the conventional method of Chinese medicinal preparations. The Chinese medicinal composition can improve symptoms such as calvities, alopecia areata and the like quickly and obviously, promotes hair to grow, has the effects of hair growth, hair nourishing, hair care, hairdressing and the like, and has definite clinical effects, quick response and obvious curative effect. The Chinese medicinal composition does not have irritation to skin or dependence, and has the advantages of low cost, no toxic or side effect and the like by combining medicaments formulated by National Formulary completely and adopting a method of external treatment.

The invention provides natural composite anti-hair-loss hair-growing liquid for external use, belongs to the technical field of traditional Chinese medicine preparations, and solves the problem that minoxidil is added in a conventional product. The hair-growing liquid comprises raw materials of cacumen biotae, fresh ginger, polygonum multiflorum, safflower carthamus, angelica, broadleaf holly leaves, asparagus lettuce seeds, pseudo-ginseng and ginseng as well as auxiliary materials of sodium acrylate, azone and vitamins C. A clinical test proves that the hair-growing liquid has unique treatment effects for patients with alopecia seborrhoeica, alopecia areata, neuropathic alopecia, endocrine dyscrasia alopecia, nutrition metabolism alopecia and chemical alopecia; the hair-growing liquid is a pure natural extracted essence component, does not have the shortcomings of causing side effects, causing an injury to a human body, containing any chemical component, influencing hypertension and hypotension and changing blood pressure of blood vessels and blood flow, and has hair-growing and hair-blackening effects.

The invention relates to a hair-growing nourishing capsule. The raw material components for preparing the active ingredients and the proportioning by weight are as follows: black zoysia pungens: 10 to 20 portions, radix-polygoni multiflori: 45 to 55 portions, fruit of glossy privet: 45 to 55 portions, eclipta alba: 40 to 50 portions and mulberry: 40 to 50 portions. The hair-growing nourishing capsule has obvious effects of inhibiting hair losing and promoting hair growth, with desired and fast effect, thus being suitable for the hair losing patients caused by various caused, and in particular having obvious effect for curing seborrheic alopecia and alopecia areata, etc.

The invention relates to the technical field of stem cells and hair loss treatment, and in particular relates to a hair regeneration method for mesenchymal stem cell-induced alopecia areata and an application. The invention provides a new application of the mesenchymal stem cells, namely the application of the mesenchymal stem cells in preparation of products for hair regeneration of induced alopecia areata, the hair regeneration method for the mesenchymal stem cell-induced alopecia areata, and an animal model for hair regeneration after alopecia areata built by the method. The hair regeneration method can be applied to hair follicle regeneration research and alopecia areata treatment.

The invention relates to a method for chemically plating a metal film on a porous matrix, that is, before the chemical plating, an activated matrix is preheated in hot water, and the preheating temperature is higher than the normal temperature of the chemical plating. The chemical plating can be initiated quickly as soon as the hot matrix contacts a plating solution, so that an even and continuous metal film is formed on the surface of the matrix to lay a good foundation for the growth of subsequent films. The method effectively avoids the problems of uneven plating coats or even alopecia areata, and improves the adhesive force of the metal film.

The invention relates to a purely natural shampoo which is manufactured by the following Chinese medicine raw materials according to parts by weight: 25-30 parts of linseed, 12-15 parts of fructus psoraleae, 8-10 parts of rhizoma drynariae, 20-25 parts of angelica sinensis, 25-30 parts of prepared fleece flower root, 20-25 parts of cacumen biotae, 8-10 parts of fructus viticis, 5-10 parts of apricot kernel, 5-6 parts of mother chrysanthemum, 8-10 parts of cortex meliae, 5-6 parts of radix sileris, 5-6 parts of duckweed, 13-15 parts of yerbadetajo herb, 13-15 parts of fructus ligustri lucidi, 7-10 parts of root of common peony, 12-15 parts of Chinese rhubarb, 8-10 parts of hemlock parsley, 8-10 parts of radix angelicae, 5-7 parts of xanthoxylum piperitum and 5-8 parts of glycyrrhiza uralensis. The purely natural shampoo is used for people suffering from scalp diseases such as dandruff, greasy hair, dry hair, white hair, alopecia areata, alopecia, head wind, head spot and the like, and is safe and nontoxic and obvious in effect after the purely natural shampoo is used.

The invention relates to a formula of a traditional Chinese medicine for treating alopecia areata. According to the formula, the traditional Chinese medicine is prepared from black soybean, mirabilite, sodium borate, dried alum, borneol and sesame oil. The traditional Chinese medicine is applied to wounds for multiple times in a day, and 10 days is one course of treatment. The traditional Chinese medicine has the characteristics of simplicity of operation, no side effect, high efficiency and small investment.

Covalent Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. A method for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.

The present invention relates to alopecia areata treating externally applied medicine preparation, and is especially preparation process of minoxidil solution and minoxidil liniment sheet. The minoxidil solution is prepared with minoxidil, 1, 2-propylene glycol, ethanol, sodium thiosulfate, tetrabutyl ammonium hydrochloride and water in certain proportion. The preparation process includes dissolving minoxidil in 1, 2-propylene glycol and ethanol solution through heating to 40 deg.c; dissolving sodium thiosulfate and tetrabutyl ammonium hydrochloride in water; and mixing to obtain the minoxidil solution. The minoxidil solution is added to base sheet of water absorbing carrier in surface area of 10-50 sq cm to form the minoxidil liniment sheet, which is sealed in bag for maintenance.

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a basic anti-inflammatory agent, such as indometacin; one or more optional active principles selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol TM , L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR- gamma) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF- alpha) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.

The invention relates to an application of a mesenchymal stem cell exosome preparation in treating alopecia areata. An exosome preparation includes exosome secreted by human umbilical cord mesenchymalstem cells and PBS. A preparation method of the exosome secreted by the human umbilical cord mesenchymal stem cells includes placing the umbilical cord mesenchymal stem cells separated from the umbilical cord of a full-term normal delivered healthy fetus to perform culture at 37 DEG C to P3; performing replacing in a DMEM / HAM'SF-12 culture medium without fetal bovine serum when the cells are fused to 60-80%, and performing starvation culture for 48 h, and then collecting the culture medium; performing centrifugation on the collected culture medium to remove the cells and cell debris, and extracting the exosome by using a ultracentrifugation method; and obtaining the mesenchymal stem cell exosome preparation UC-MSCs-Exo by performing conservation at -80 DEG C with a PBS re-suspended sediment. The UC-MSCs is low in preparation cost, abundant in source and convenient in collection and has no traumatic operation on human bodies; the UC-MSCs-Exo is simple in component, stable in cell factor and not easy to denature; and therefore, the skin tissue structures at alopecia areata parts can be improved, and the damaged hair follicles can be repaired or reconstructed.

Proline compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.

Methods for the treatment of skin disorders, including psoriasis, atopic dermatitis, allergic contact dermatitis, alopecia areata, skin cancers, and related disorders, such as psoriatic arthritis are provided, such methods comprising administering a composition having antigenic and / or adjuvant properties. Compositions which may be usefully employed in the inventive methods include inactivated M. vaccae cells, delipidated and deglycolipidated M. vaccae cells, M. vaccae culture filtrate and compounds present in or derived therefrom, together with combinations of such compositions.

The present invention relates to a species and a liniment for curing alopecia areate, seborrheic alopecia and nervous alopecia with obvious reliable therapeutic effect, in which the species can be made of 25 Chinese medicinal materials of flowery knotweed root, uncaria stem and thorn, tangerine peel, astragalus root, Chinese angelica root and others, and the liniment is made of 18 Chinese medicinal materials of carthamus flower, dried ginger, frankincense, myrrh, bushy knotweed root and others.

The invention discloses equipment for treating vitligo by utilizing turnable lattice dual wavelength laser. A superpulse CO2 laser device and an ultraviolet laser device are integrated in the equipment. Under the control of a control system, the superpulse CO2 laser and the ultraviolet laser can be outputted according to pulse width, peak value power and pulse power, which are required by therapy, are respectively outputted through a beam switcher according to requirements, and are outputted to a two-dimensional optical scanning polariscope system through a coupler and a guiding arm. Then, the laser beams are outputted by the optical scanning system in a lattice distribution form, and are irradiated on focuses of skin surfaces of patients after being focused by a focusing mirror, thus, the equipment for treating vitligo by utilizing turnable lattice dual wavelength laser is manufactured. The device is mainly used for treating vitligo, particularly is suitable for treating acral vitligo, and is also suitable for treating neurodermatitis (hypertrophic type), chronic eczema, psoriasis, trichophytia, alopecia areata, scleriasis, lymphoma cutis and the like.

The invention discloses hair-growing essential oil which comprises the following components in percentage by volume: 30-40% of lavender essential oil, 30-40% of fresh ginger essential oil, 18-33.4% of rosemary essential oil and 0-10% of base oil. The hair-growing essential oil disclosed by the invention has a good treatment effect to alopecia areata, postpartum alopecia, alopecia seborrhoeica, grey hair, senile hair loss, other male hormone alopecia and pathological alopecia and has a good repairing effect to damaged hair and hair quality. Meanwhile, the hair-growing essential oil which adopts pure natural plant essence is safe and free from side effect in the using process, can be used for people of all ages and both sexes, and is simple and convenient to use.