3478 results about "Cutis" patented technology

The invention provides a transcutaneous medical device (502, 250, 150, 600) comprising a lower surface adapted for application towards the skin of a subjet, attaching means (571, 272, 161) for securing the lower surface relative to the skin, and a transcutaneous device (530, 182, 213, 651) adapted to penetrate the skin of the subject. The transcutaneous device is mounted for movement be-tween an extended position in which the transcutaneous device projects relative to the lower surface and a retracted position in which the transcutaneous device is retracted relative to the lower surface. The medical device further comprises release means (550, 275, 162) which can be oper-ated from a first state through an intermediate state to a second state, whereby operation of the release means from the first to the intermediate state causes the transcutaneous device to be moved from the extended position to the retracted position, and operation of the re-lease means from the intermediate to the second state causes release of the attaching means.

A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and / or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.

I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA / UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, "love handles" in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery system.

An integrated lancet and testing striplet for measuring a body analyte level in a health care regimen includes a skin piercing member and an analyte sensor coupled together.

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and / or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Biocompatible materials are propelled at the skin with sufficient velocity to cause desired resurfacing of skin layers to the desired penetration depth. The materials, such as dry ice or water ice, are harmonious with the human body and thus eliminate foreign body reactions. Various materials may be used in combination, including local anesthetics and vasoconstrictors in solid or liquid form. The biocompatible solid or liquid particles are suspended in a cold carrier fluid and propelled through an insulated delivery system to the surface of the skin. The treatment of diseased skin lesions may be accomplished using the present invention as a drug delivery system.

A method of delivery of a substance to a human subject's skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of s pre-selected volume of the substance, e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.

An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.

The present invention concerns a method and a kit, for the treatment of a selected area of the skin and / or subcutaneous tissue, and in particular for the cosmetic treatment of skin conditions such as regional fat deposits including cellulite. The method comprises heating the selected area to a sustained skin temperature of about 32 to about 50° C. for a desired period of time, using a device comprising either a heat source capable of conductively heating the selected area or, alternatively, an infra-red source for emitting infra-red with a wavelength from about 700 nm to about 15000 nm. The method also comprises administering, simultaneously or sequentially in either order, a composition containing an active agent selected from the group comprising a skin active, a nutrient absorption suppressant or a thermogenic agent, preferably a metabolic stimulating agent, more preferably a lipolytic agent, or a mixture thereof, the composition being either a topical composition for application to the selected area, or an area adjacent thereto, or an oral composition.

The invention relates to methods of treating baldness, treating alopecia, promoting hair growth, and / or promoting hair follicle development and / or activation or stimulation on an area of the skin of a subject (for example, a human) by subjecting said area of the skin to integumental perturbation. Integumental perturbation can be used in combination with other treatments for promoting hair growth. The invention provides devices for integumental perturbation for promoting hair growth, and provides pharmaceutical compositions for use in combination with integumental perturbation for promoting hair growth.

The delivery of a fluid cutaneously is effected by generating a suction force on a surface of a housing. A surface of a cutaneous layer is received under the suction force about which the proximal end of a needle thereby to pierce the cutaneous surface and to effect an injection of fluid. There is generated a suction force to operate the movement of a needle in the housing. The needle is moved under the suction force from the housing thereby to permit piercing a cutaneous layer. The bladder for containing fluid is emptied under the suction into the distal end of the needle and thereby permit the expulsion of fluid through the proximal end of the needle for injection below the cutaneous layer.

Systems, devices and methods for determining the concentration of physiological fluid analytes are provided. The subject systems have a plurality of biosensor devices present on a disposable cartridge. Each biosensor device includes a biosensor and a skin penetration means. In practicing the subject methods, a movement means of the device is used to move each biosensor device in a first direction that provides for penetration of the skin-piercing means into a skin layer followed by movement of the biosensor in a second direction that provides for removal of the skin-piercing means from the skin layer, where this movement profile provides for physiological fluid access and analyte concentration determination by the analyte sensor means. The subject systems, devices and methods for using the same find use in determining the concentration of a variety of different physiological fluid analytes, and are particularly suited for use in detection of physiological fluid glucose concentration.

Peptides of general formula (I): R1AA1-AA2-AA3-AA4-R2 stereoisomers thereof, mixtures thereof or the cosmetically or pharmaceutically acceptable salts thereof, a method for obtaining them, cosmetic or pharmaceutical compositions containing them, and their use for the treatment and / or care of those conditions, disorders and / or pathologies of the skin, mucosae and / or scalp resulting from matrix metalloproteinases (MMP) overexpression or an increase in the MMP activity.

A transcutaneous device dressing and method for its use with a transcutaneous medical device, such as an intravascular catheter, which punctures the skin of a patient and which has a portion of the medical device protruding from the skin which can lead to infection. The dressing includes a top and a bottom dressing, both being formed from a flexible material and having upper and lower surfaces, with the lower surface being the skin facing surface in use. The bottom dressing has a slit formed therein extending from one edge inwardly to a termination point within the confines of the bottom dressing. An anti-microbial material is provided without the use of adhesives at the upper and lower surfaces of the bottom dressing, and at least at the lower surface of the top dressing. In use, the bottom dressing is placed next to the skin, the slit allowing the bottom dressing to surround the puncture site such that the lower surface of the bottom dressing is in contact with the skin while the upper surface of the bottom dressing is in contact with a portion of the medical device protruding from the skin. The top dressing is placed above the puncture site such that its lower surface is in contact with a portion of the medical device protruding from the skin. In this way, there is exposure of the portion of the medical device protruding from the skin to the anti-microbial activity of the anti-microbial material.

System and method for non-invasive lysis of sub-dermal tissue by means of focused ultrasonic energy, the system comprising: a source of ultrasonic energy adapted to operate in continuous wave mode and to focus ultrasonic energy in a focal zone within the sub-dermal tissue, the ultrasonic energy being adapted to induce tissue cavitation in the focal zone; means for continuous displacement of the source over the skin surface; and means for determining a safe speed for the displacement, the safe speed allowing to avoid thermal tissue damage. The source of ultrasonic energy is accommodated in a hand-held applicator including a wheeled traction system powered by an electric drive.

A skin incision device has a casing having a bottom surface with a slot formed therein, a cover positioned on the casing and slidable in a direction toward the bottom surface, a blade positioned in the casing adjacent the slot, an actuator cooperatively positioned between the cover and an interior of the casing, and a carriage element. The actuator engages the blade by its horizontal displacement triggered by the slidable movement of the cover toward the bottom surface of the casing. The carriage element guides the movement of the blade between a pre-actuated position and a post-actuated position. The blade moves outwardly through the slot, cuts with a horizontal movement, and returns inwardly through the slot.

The present invention comprises antimicrobial articles for use with a percutaneous device, comprising a matrix which may contact the percutaneous device in a three-dimensional mode and release antimicrobial agents (e.g., silver ions) to the percutaneous device access site. In addition, the antimicrobial article of the present invention may donate moisture to a dry dermal site (e.g., a dry wound bed) and / or absorb liquid or exudates of a dermal site. The present invention also comprises methods for treating and / or preventing an infection using the antimicrobial articles of the present invention.

Devices and methods aimed at shortening the time required for healing open wounds are disclosed. The tissues adjacent to wounds are expanded and / or stretched medially by means of an actuator which compressed by vacuum exerts traction on adjacent skin or tissues by means of an adhesively applied circumferent or transverse flange, thus reducing the size of the wound. The degree of vacuum, and traction, may be varied according to demand and applied continuously, cyclically or intermittently. Active treatment of the wound may be accomplished concomitantly by means of a conduit through the said actuator.

Disclosed is an apparatus and method which employs an energy source, one or more switches, electronic control circuitry, and a surface that can be placed in contact with a region of a person's skin containing a benign pigmented lesion. Within the apparatus, electrical current is passed through a heating element that is thermally coupled to the surface so that this surface is heated rapidly and then is subsequently cooled rapidly. By judicious choice of the rate of heating, maximum temperatures achieved, and rate of cooling, thermal injury to the skin can be confined primarily to the epidermal region of the skin in contact with the surface.

A surgical thread is made of a metal, polymer or biological material embodied in the form of a spiral whose diameter ranges from 0.5 to 5 mm. The thread has a diameter ranging from 0.1 to 1 mm and exhibits the properties of a compression or extension spring obtainable by heat treatment. Also a method is disclosed which is characterized in that it consists in introducing the spiral-shaped thread into subcutaneous soft tissues in order to tighten and fix said tissues by means of a puncture needle in bore of which a thread-spiral exhibiting the properties of a compression or extension spring is fixed from outside or from inside. When the needle is extracted the thread-spiral remains under skin preserving the compression or extension properties thereof, thereby producing a skin compression or extension effect.

Methods, systems, and devices to treat a region of skin; the treatment may be used to stimulate the production of collagen or destroy adipose tissue. The region of skin is exposed to a uniform energy application or series of applications. The region of skin may be exposed to positive and negative pressures. Therapeutic substances may be applied to the region of skin.

A device and a method for thermal treatments of target material with various thermal interactions are disclosed. A device for treating hair on the skin comprises a treatment head coupled to a housing; a hair remover for removing the hair from a target area of the skin; a light source for transmitting a predetermined amount of energy to the skin. A device and method for treatment of tissue. The device comprises of an energy source for treatment of surface and subsurface tissue, And of a mechanical source of energy for mechanically deforming the treated tissue. Both the Mechanical Energy (ME) and the Treatment Energy (TE) may be either continuously operating (CO) or modulated in time and space.

The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and / or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and / or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.

Various systems, methods and materials are disclosed that enable efficient delivery of an agent into an adhesively adhered article, in which the agent elicits a desired outcome, on demand. This strategy, though general in scope, is also more specifically described with regard to enabling painless or atraumatic removal of products adhering to mammalian tissues such as skin and hair by suitably exploiting the ingress of an appropriate agent or like fluid. Other techniques and articles that aid in the handling or removal of such adhesive products are also disclosed.

Topical skin care compositions are provided for the improvement of the appearance of the skin, namely of the skin comprising the face, surrounding the eyes, mouth, and hands, as well as the skin of the body. The skin care compositions include synergistic combinations of active peptide ingredients that are specially formulated to enhance the natural appearance of the face, hands, and / or body. Specifically, the synergistic skin care compositions may be applied to one or more of the skin surrounding the eyes, mouth, nose, forehead, ears, neck, hands, feed, and overall body to give the skin thereof a cleaner, smoother and more wrinkle free appearance.

The present invention relates to microclosures and methods for treating microwounds in the skin (e.g., after incising or excising tissue portions from a subject). Exemplary microclosures include a material having at least one dimension of from about 10 um to about 1 mm after application to a microwound. The microclosure maintains a first compressive force when applied to the microwound.