A
biopsy system is provided including a housing and a
biopsy instrument operatively associated with the housing and configured and dimensioned to remove a
tissue sample from a patient. A firing module is included that is detachably engageable with the housing and operatively associated with the
biopsy instrument to facilitate selective rapid advancement of at least a portion of the biopsy instrument toward a targeted location with the patient. The biopsy instrument includes a tissue receiving portion. The
system may include an indexing
assembly disposed within the housing and configured to cooperate with the biopsy instrument to selectively orient the tissue receiving portion. The indexing
assembly may include a manual gearing
assembly configured for selective orientation of the tissue receiving portion. The
system may include a linear advancement control assembly disposed within the housing and configured to effect linear actuation of a tubular knife member. An optical sensor may be disposed adjacent a portion of the tubular knife member and oriented to detect the orientation of a lateral opening formed through the tubular knife member. A
carriage may be slidably disposed within the housing and configured to releasably retain at least a portion of the biopsy instrument. A method of performing a surgical biopsy is disclosed.