70results about How to "High drug loading efficiency" patented technology

The invention discloses a preparation method and application of a conductive hydrogel capable of slowly releasing drugs and factors. The preparation method comprises the following steps: step 1, a conductive macromolecular monomer solution is prepared, an oxidant is added, and after sufficient reaction, a conductive macromolecular polymer is obtained; step 2, a concentrated aqueous dopamine solution is prepared, the conductive macromolecular polymer obtained in step 1 is added, and after sufficient reaction, a polydopamine / conductive macromolecular polymer compound is obtained; step 3, a metalion salt solution and an organic ligand solution are prepared; step 4, the polydopamine / conductive macromolecular polymer compound is added into the metal ion salt solution, and after uniform mixing,the organic ligand solution is added; and reaction is sufficiently carried out; step 5, the metal-organic framework / polydopamine / conductive macromolecular polymer compound is added into a monomer ordouble-bond biomacromolecular solution; and after additive is added, the needed hydrogel is formed by polymerization. The conductive hydrogel has excellent conductivity and electrochemical activity, and can be used in the preparation of drug carriers and biological electrodes.

The invention provides a preparation method of a hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets. The preparation method comprises following steps: step 1, molybdenum disulfide nano tablets are obtained via hydro-thermal synthesis; step 2, the molybdenum disulfide nano tablets are added into a gelatin solution, and gelatinized molybdenum disulfide nano tablets are obtained via sufficient reaction; step 3, lactobionic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and N-hydroxy succinimide are weighed and added into the gelatinized molybdenum disulfide nano tablets so as to obtain lactobionic acid modified molybdenum disulfide nano tablets; and step 4, a doxorubicin hydrochloride aqueous solution is prepared, and the lactobionic acid modified molybdenum disulfide nano tablets obtained via step 3 are added into the doxorubicin hydrochloride aqueous solution, an obtained mixture is stirred for 8 to 24h under vacuum conditions, and is subjected to centrifugalization and washing so as to obtain the hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets via collecting. The hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets can be used for photothermal therapy and CT imaging, and can be used for realizing combination of diagnosis and treatment of hepatoma carcinoma.

The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.

The invention relates to a preparation method of a macromolecular multi-layered hydrogel drug sustained-release material. The preparation method mainly includes steps of performing laminar superimposition function on the proper mixture ratio and composition of polyanion macromolecular blended solution A and polycation macromolecular blended solution B through a micro-bedding co-extruding device, sealing and placing the solution A and solution B to make them crosslink slowly and completely to realize structuring of macromolecular polyelectrolyte loaded with drugs, and to prepare a macromolecular polyelectrolyte hydrogel drug loading system with flexible and controllable drug form distribution, flexible and controllable drug sustained-release performance and having alternative multilayered structure, so as to meet different drug sustained-release demands. Compared with the traditional method of preparing the macromolecular multi-layered hydrogel drug sustained-release material by superimposition layer by layer, the method is a continuous production method, and good for improving the production efficiency; the technique is simple, and product quality index between different batches is stable; the preparation can realize the large-scale industrial production, is wide in application scale and has wide industrial and market prospect.

The invention discloses an ultrasonic controlled release medicine elution balloon catheter and a preparation method. The surface of the medicine elution balloon catheter is coated with a medicine coating, the medicine coating is composed of a fat-soluble medicine carrying microcapsule having a ultrasonic response characteristic and an adhesive having a water-soluble characteristic. Medicine of the medicine elution balloon catheter is wrapped in a lipophilic medicine carrying microcapsule which is hard to dissolve in the blood, so medicine loss caused by blood washing can be reduced. When the ultrasonic controlled release medicine elution balloon catheter is used, the medicine elution balloon catheter is sent to a lesion portion and unfolds, a balloon contacts with the lesion tissues, ultrasound inducts the lesion portion at the external, the medicine carrying microcapsule can be speeded up to be separated from the hydrophilic adhesive, medicine can diffuse in the fat-soluble lesion tissues, at the same time, the medicine carrying microcapsule having the ultrasonic response characteristic breaks under the function of the ultrasound and discharges the medicine, the efficiency of medicine absorption and utilization by the target lesion tissues can be greatly raised. The amount and time of medicine discharge can be controlled through adjusting the characteristic and the ultrasonic characteristic of the medicine carrying microcapsule, the validity and safety of the medicine elution balloon catheter can be improved.

The invention belongs to the technical field of dosing equipment, and relates to a bubble-type microneedle and a preparation method therefor. The microneedle comprises a microneedle substrate, a drug-carrying microneedle body arranged on the microneedle substrate, and a paster bonded with the microneedle substrate. The drug-carrying microneedle body is conical or shaped like a cone, wherein the height of the drug-carrying microneedle body is from 100 microns to 1000 microns, the bottom diameter is from 50 microns to 1000 microns and the interior of the drug-carrying microneedle body comprises a bubble structure. Drug is gathered at the tip or upper part of the drug-carrying microneedle body. Compared with the prior art, the microneedle is advantageous in that the special bubble-type structure enables the drug to be gathered at the upper end of the needle body and not to diffuse downwards, and improves the load carrying efficiency; the bubble-type structure enables the actual lateral thickness of the lower end of the needle body to be reduced, thereby shortening the subcutaneous dissolution time, and facilitating the dosing for different objects; the source of the raw material of the microneedle is extensive, the consumption of the raw material is small, and the raw material is saved; the prepared microneedle is uniform in structure, and the size of the microneedle can be controlled; the preparation method is simple and feasible, is easy to operate, and can achieve the industrialization.

The invention discloses a preparation method of macromolecular laminar drug-loaded hydrogel with controllable drug distribution. The preparation method mainly includes steps of performing multiple times of laminar superimposition on polyanion macromolecular blended solution A with appropriate proportion and composition and polycation macromolecular blended solution B with appropriate proportion and composition through a microlayer co-extrusion device, and sealing and placing to allow the solution A and the solution B to crosslink slowly and completely to realize structuring of drug-loaded macromolecular polyelectrolyte so as to prepare a macromolecular hydrogel drug loading system with flexible and controllable drug form distribution and drug release performance and with an alternative multilayered structure to meet different drug release demands. Compared with a traditional method using layer-by-layer superposition to prepare the macromolecular laminar drug-loaded hydrogel, the method has the advantages that the method is a continuous production method and beneficial to the improving of production efficiency; the method is simple in process, the product quality indexes of different batches of produces are stable, and the method is capable of achieving large-scale industrial production, wide in application range and promising in industrialization and market prospect.

The invention discloses a preparation method of succinic-anhydride-modified corn prolamin drug-loading particles. The method comprises the following steps of: dissolving corn prolamin in dimethyl sulfoxide or ethanol aqueous solution, regulating pH of the solution to 10-11, then mixing with succinic anhydride, reacting for 1-2 hours at a temperature of 40-45 DEG C, keeping the pH of the solution being alkaline in the reaction process, obtaining succinylated corn prolamin liquid, placing the liquid in a dialysis bag for dialysis after reaction is ended, freezing and drying into powdery solid, and dissolving hydrophobic drugs and freeze-dried succinylated corn prolamin in the ethanol aqueous solution; filling hydrochloric-acid aqueous solution under stirring, and after stabilizing, centrifuging to remove supernatant, thus obtaining the drug-loading particles. The preparation method disclosed by the invention has the beneficial effects that the prepared drug-loading particles are high insphericity degree, good in dispersity, narrow in particle-size distribution and uniform in size, the stability is obviously improved compared with unmodified corn prolamin particles under the physiological pH environment, the slow release effect is good, and the prepared drug-loading particles can be used for oral or sucking type administration or be prepared into suspensions for injection use.

The invention discloses a tumor-targeted photodynamic medicine carrying nanoparticle as well as a preparation method and an application thereof, belonging to a medical preparation containing porphyrin or a medical preparation prepared by a method which utilizes wave energy to process materials. According to the invention, porphyrin or derivates of porphyrin of a functional group and polyethylene glycol and polypropylene glycol of a polyether chain segment are connected through chemical bonds or ester bonds or amido bonds of perssads, and then polymerized into a nanoparticle aqueous dispersion of porphyrin or derivates, loaded with a chemotherapy drug with a conjugated structure and dialyzed to obtain the tumor-targeted photodynamic medicine carrying nanoparticle. The nano material prepared by the method is high in yield, regular in shape, uniform in distribution and good in biosecurity, can be effectively loaded with an antitumor drug with a conjugated structure; a water-soluble photosensitizer can effectively reverse drug tolerance of a chemotherapy drug after being irradiated by near-infrared light; the nanoparticle can efficiently target and position tumors, has good anelasticity, effectively inhibits tumor growth, and has a wide application prospect in preparing breast cancer tumor-targeted drugs.

The invention discloses a fusion protein, the amino acid sequence of which contains an iRGD peptide sequence shown as SEQ ID No:1 and a molecular chaperone GroEL sequence shown as SEQ ID No:2. The invention further discloses an encoding gene of the fusion protein, the sequence of which is a nucleotide sequence capable of encoding the fusion protein. The invention further discloses a preparation method of the fusion protein. The preparation method comprises the following step of expressing the encoding gene in a bacterial strain to obtain the fusion protein. A method of preparing a pharmaceutical composition comprises the following steps of contacting the pharmaceutical compound with the fusion protein disclosed by the invention to obtain a contacted material in the presence of a solvent. The invention further discloses the pharmaceutical composition prepared by the method of preparing the pharmaceutical composition. The fusion protein provided by the invention can stably load a hydrophobic drug, and is high in drug-carrying efficiency and good in drug release effect. The pharmaceutical composition prepared by the fusion protein provided by the invention has the advantages of good biocompatibility and good drug release effect.

The invention discloses a preparation method of esomeprazole magnesium enteric-coated pellets and belongs to the field of medicinal preparations. The preparation method comprises the following steps:(1) preparing pill cores of the pellets; spraying and coating 100 to 200 weight parts of sucrose pill cores with a medicine-containing coating solution in a fluidized bed by utilizing a bottom spraying manner, so as to form medicine-containing pill cores; (2) coating an isolation coating layer; coating the medicine-containing pill cores with the isolation coating in the fluidized bed by utilizingthe bottom spraying manner; (3) coating an enteric coating layer; coating the medicine-containing pill cores covered with the isolation coating with the enteric coating in the fluidized bed by utilizing the bottom spraying manner, so as to obtain the enteric-coated pellets with the size of 18 to 20 mesh.

The invention discloses application of targeted reduction response vesicular nanometer medicines in preparation of brain tumor treatment medicines. Reduction sensitive reversible crosslinking vesiclesbased on block polymers PEG-P(TMC-DTC), PEG-P(LA-DTC), PEG-P(TMC-DTC)-PEI, PEG-P(LA-DTC)-PEI, PEG-P(TMC-DTC)-Sp or PEG-P(LA-DTC)-Sp and targeting polymers with ANG as the targeting molecules can efficiently wrap small-molecular chemotherapy medicines, protein medicines and gene medicines sensitive to brain glioma cells. The medicine-carrying vesicles can efficiently permeate through a blood brainbarrier in vivo to enter tumor substances and can also rapidly release medicines after entering tumor cells to induce cell apoptosis. The system has the advantages that the process is simple, the carrier biocompatibility is good, the enrichment of medicines at brain tumor parts is remarkably improved, and the concentration of medicines in brain tumor cells is increased. By means of the system, medicines can be conveyed to brain glioma selectively and efficiently.

The invention discloses a preparation method of a silicon-nanowire-based medicinal carrier. The method comprises the following steps of: preparing a system of between 20 and 200mg / ml from the silicon nanowire with buffer; adding an antitumor medicament to obtain mixed liquid; oscillating for 3 to 30 hours at a temperature of between 20 and 37 DEG C; centrifuging, and washing with the same buffer for 3 to 10 times; and removing the antitumor medicament which is not combined on the upper layer to obtain the lower precipitate, which is silicon nanowire-antitumor medicinal composition. According to the method, the load efficiency of a traditional antitumor medicament in a carrier can be greatly improved along with safe operation, quickness and convenience; and the obtained silicon nanowire-antitumor medicinal composition can play an excellent role in killing cancer cells on cell and living body levels, and plays an effect of medicament sustained release, so that tumor growth can be inhibited in a long time. The silicon-nanowire-based medicinal carrier can be used as a nano-medicament due to the great loading efficiency of the silicon nanowire, and can be widely applied to the field of cancer treatment.

The invention discloses a use of a single targeted reduction-responsive vesicle nano-drug in preparation of a drug for treating brain tumors. Through reduction-responsive reversibly crosslinked vesicles of block polymers such as PEG-P(TMC-DTC), PEG-P(LA-DTC), PEG-P(TMC-DTC)-PEI, PEG-P(LA-DTC)-PEI, PEG-P(TMC-DTC)-Sp and PEG-P(LA-DTC)-Sp and a targeting polymer using ApoE as a targeting molecule, small-molecule chemotherapeutic drugs, protein drugs and gene drugs sensitive to brain glioma cells are efficiently encapsulated. The drug-carrying targeting vesicles can efficiently target multiple receptors (including LRP-1, LRP-2 and LDLR) that are highly expressed on the surfaces of brain microvascular endothelial cells in tumor regions thereby efficiently penetrating the blood-brain barrier andbeing efficiently enriched in the brain tumor region. ApoE-targeting related receptors are also highly expressed on the surfaces of glioma cells so that the drug-carrying targeting vesicles can be efficiently endocytosed by glioma cells and fast release drugs to induce apoptosis.

The invention provides a preparation method of carrier-free macrolide immunosuppressive drug nanoparticles. The carrier-free macrolide immunosuppressive drug nanoparticles are self-assembled to form micromolecular carrier-free nanoparticles through a solvent exchange method, so that the water solubility of a macrolide immunosuppressive drug is effectively improved, and the concentration dependencyinhibits the growth of tumor cells. The method has the advantages that the operation is convenient, simple and practical, and the prepared nanoparticles are small in particle size, high in drug-loading efficiency and good in stability, thereby improving the availability of the macrolide immunosuppressive drug.

The invention discloses a micro needle transdermal patch for treating osteoarthritis and a preparation method thereof. The micro needle transdermal patch is prepared from bark of oriental variegated coralbean, radix achyranthis bidentatae, tinospora sinensis(Lour.)Merr., caulis spatholobi, radix clematidis, rhizoma homalomenae, herba lycopodii, lignum sappan, raw folium artemisiae argyi, herbs of tuberculate speranskia, rhizoma corydalis, seeds of peppertree pricklyash and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the medicament is stored in the micro needle gaps and a porous structure, the back face of the base plate is a plane and is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being good in curative effect, quick in effect initiating, nearly free of damage to human skin and free of toxic or side effect.

The invention relates to a TPGS-reduced albumin nanoparticle preparation entrapped with taxol and a preparation method. According to the preparation, TPGS-reduced albumin is synthesized, and then taxol, TPGS-reduced albumin, water for injection and the like are used for preparing the TPGS-reduced albumin nanoparticle preparation entrapped with taxol. The preparation can form nanoparticles with a high drug loading capacity and improve enrichment of a drug in tumors through passive targeting, and meanwhile the carrier material achieves a certain multi-drug resistance resisting effect and plays a synergic anti-cancer role.

The invention discloses a PEG (polyethylene glycol)-polylysine / isothiocyanate bonding compound and further provides a preparation method of the bonding compound. The preparation method comprises stepsas follows: (1), a PEG-polylysine block polymer is prepared by ring opening polymerization, or PEG-dendritic polylysine is prepared by a condensation reaction; (2), PEG-polylysine prepared in step (1) is subjected to a reaction with isothiocyanate compounds, and the PEG-polylysine / isothiocyanate bonding compound is prepared. The prepared bonding compound is good in biocompatibility and high in bio-safety, has controllable hydrophilcity and hydrophobicity and can be taken as a drug delivery carrier with hydrogen bond interaction, and nanomicelles which are distributed uniformly and coated tightly can be prepared from the carrier, are high in drug loading ratio, small in particle size and stable in vivo and have low systemic toxicity and long cycling time.

The invention discloses a compound traditional Chinese medicine micro needle transdermal patch for treating psoriasis and a preparation method. The compound traditional Chinese medicine micro needle transdermal patch is prepared from medical raw materials including rhizoma bletillae, rhizoma areactylodis lanceae, sichuan coptis roots, realgar, golden larch bark, herba ephedrae, chaulmoogratree seeds, radix saposhnikoviae, scolopendra, aurine, fructus cnidii and herba schizonepetae and auxiliaries including polysorbate-80, granulesten, glycerin monostearate and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the back face of the base plate is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being precise in medicine components, free of pain, capable of being released slowly, efficient and convenient to apply.

The invention discloses a biocompatible cross-linking micro-nano material for drug encapsulation and sustained release and a preparation technology of the biocompatible cross-linking micro-nano material for drug encapsulation and sustained release. A biological material takes polyacrylate microbubbles or nano particles as a matrix, chitosan as a coating material, genipin as a cross-linking agent and doxorubicin as a model drug, and drug encapsulation and release characteristics are investigated. The micro-nano material prepared according to the preparation technology has the advantages that the entrapment efficiency and the encapsulation efficiency are improved to a certain degree, and the in-vitro drug release speed can be controlled moderately. The preparation technology has the advantages of simple steps, mild conditions, technological environment friendliness, low energy consumption, no 'three wastes', no radiation and no noise, thereby being a universal technology for biocompatible cross-linking of micro-nano particles.

The invention relates to a preparation method of a polymaleic anhydride-phosphatidyl ethanolamine graft polymer nano-photosensitive carrier. The preparation method comprises the following steps: (1) synthesizing a polymaleic anhydride-phosphatidyl ethanolamine graft polymer, namely, firstly performing ring opening by using poly(1-octadecene / maleic anhydride), taking poly(1-octadecene / maleic anhydride) and phosphatidyl ethanolamine as raw materials, and performing ring-opening reaction to prepare a polymaleic anhydride-phosphatidyl ethanolamine amphiphilic polymer; and (2) preparing a polymaleic anhydride-phosphatidyl ethanolamine graft polymer nano-photosensitive preparation according to a thin film dispersion method. The preparation method disclosed by the invention is simple and convenient to operate, strong in applicability and low in cost; the polymaleic anhydride-phosphatidyl ethanolamine graft polymer nano-photosensitive carrier has relatively good solubility in water and a variety of organic solvents, and ensures that the grafting efficiency can reach 10-30%; the effective particle size of the photosensitive preparation is between 50nm and 150nm, and more uniform particle sizes can be achieved; the photosensitive preparation is good in stability and can be stored in an aqueous solution for at least more than 2 months; and the medicine loading ratio of the photosensitive preparation can keep 10-20%, and the photosensitive preparation is high in yield and is suitable for large batch production.

The invention belongs to the technical field of medicines and discloses a cyclosporine A and amphiphilic hyaluronic acid derivative composition and a preparation method thereof. The composition is prepared from cyclosporine A and the amphiphilic hyaluronic acid derivative. The composition has the characteristics of high medicine loading capacity, good stability and good biocompatibility and can overcome such defects of the ophthalmic cyclosporine preparations as lower bioavailability and toxic and side effects. The preparation method is simple and is convenient to use.

The invention discloses a traditional Chinese medicine microneedle transdermal delivery paster for treatment of fracture and soft tissue injury and a preparation method thereof. The paster comprises the following raw materials: radix paeoniae rubra, nux vomica, safflower, tuberculate speranskia herb, epimedium, pseudo-ginseng, Radix Astragali, radix sileris, herba lycopi, eucommia, Chinese angelica, rhizoma drynariae, dragon's blood, mint and accessories comprising polysorbate-80, soybean lecithin and glycerin monostearate. The paster comprises a substrate, a medicament, an ointment blank plaster and an ointment back plaster; the front side of the substrate is provided with a plurality of microneedles with gaps therebetween; the medicament is stored in the microneedle gaps and the porous structure of the substrate; the back of the substrate is pasted on the inner surface of the ointment blank plaster; the inner surface of the ointment back plaster covers on the front side of the substrate; the inner surface of the ointment blank plaster and the inner surface of the ointment back plaster are fixedly connected by adhesion. The invention discloses the preparation steps. The paster has the advantages of good therapeutic effect, quick effectiveness, no damage to human skin and no toxic side effect.

The invention discloses a compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and a preparation method. The compound traditional Chinese medicine micro needle transdermal patch is prepared from medical materials including poria, manyflower solomonseal rhizomes, cortex eucommiae, cortex cinnamomi, herba schizonepetae, rhizoma chuanxiong, roots or stems of smoothfruit ventilago, Japanese creeper, leaves or roots of dentate wampee, silvery aleuritopteris and radix angelicae pubescentis and auxiliaries including polysorbate-80, granulesten, glycerin monostearate and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the medicament is stored in the micro needle gaps and a porous structure of the base plate, the back face of the base plate is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being precise in medicine composition, free of pain, capable of being released slowly, efficient and convenient to apply.

The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.

The invention relates to the technical field of polysaccharides, in particular to a bovine serum albumin-nano-silver modified chitosan nano-drug delivery system and a preparation method thereof. Nano-silver chitosan gel is prepared from nano-silver modified chitosan, and the obtained gel has elasticity and stability similar to those of soft tissues, can effectively prolong the in-vivo circulation time of a nano-drug delivery system, and controls slow release of drugs. According to the invention, bovine serum albumin is also added, and the bovine serum albumin has excellent transmission and metabolism effects, good biocompatibility and degradability, can promote the circulation of the material in vivo, and more effectively controls the drug release. Two alkaloid drugs including berberine hydrochloride and camptothecin are added, camptothecin has an excellent anti-tumor effect, berberine hydrochloride has the effects of improving the microenvironment for tumor cell survival and preventing tumor cell migration, and the two drugs have a synergistic effect, so that the treatment effect on tumors is better.

The invention discloses nimesulide solid dispersion micro-powder. The nimesulide is prepared by using povidone and hydroxypropyl methylcellulose as dispersion carrier materials and carrying out supercritical fluid crystallization. According to the invention, the preparation method of nimesulide solid dispersion micro-powder is operated simply under mild conditions; the controllability is high; andno solvent residue is left. The obtained nimesulide solid dispersion micro-powder is small in particle size, high in dispersity and high in stability; and the saturated solubility can reach over 5 times of that of a nimesulide raw material medicine (pH = 6.8). The micro-powder can be used for preparing solubilizing quick-release particles of nimesulide; the rapid dissolving in the dissolution medium with the pH value of 6.8 is realized; and the equilibrium dissolution rate of the micro-powder is more than two times of those of bulk drugs and nimesulide particles. Besides, the micro-powder canalso be used for preparing nimesulide tablets, capsules or suspensions and the like.

The invention discloses an artemisinin-loaded citrus pectin oral nanoparticle; a preparation method of the oral nanoparticle includes the following steps: the citrus pectin is subjected to multimolecular self-polymerization; nanoparticles are formed from the citrus pectin and wrapped and adsorbed with theartemisinin; aminophenylboronic acid is connected with the citrus pectin nanoparticles; the outer layer is wrapped with denatured chitosan. For the first time, citrus pectin and artemisinin are combined to improve insulin resistance and pancreatic beta cell injury in type II diabetes at the same time; the method of transforming pancreatic alpha cells into pancreatic beta cells is applied to nano-therapy of type II diabetes, can inhibit the secretion of glucagon and also can improve insulinsecretion; no matter drugs nor delivery materials adopt natural products from plants to ensure no toxicity and easy metabolism in the process of treatment of type II diabetes.

The invention discloses a photo-thermal responsive drug carrier based on nano titanium nitride and a microcapsule and a preparation method. The preparation method comprises the following steps, firstly, carboxylating the surface of a poly epsilon-caprolactone drug-loaded microcapsule by using alkaline solution, and then modifying amino groups on the surfaces of nano titanium nitride particles; andfinally, compounding the carboxylated drug-loaded microsphere and the titanium nitride nanoparticles with the surfaces modified by the amino groups through electrostatic interaction to obtain the titanium nitride microcapsule composite drug carrier. The microsphere prepared by the method has high drug loading rate. Titanium nitride can directly convert light energy into heat energy after being irradiated by near-infrared light, so that the composite microsphere is molten by heating, thereby improving drug release efficiency. The photo-thermal responsive drug carrier has simple preparation process and high heat production capacity at illumination, and can realize remote, high-precision and high-efficiency release of drugs. The drug-loaded microsphere has wide application prospects in the fields of clinical treatment, anti-corrosive coatings, etc.

The invention relates to a preparation method of a difunctional mesoporous silicon ball composite targeted drug delivery system, and belongs to the field of nanobiomedicine. The method comprises the steps that a coprecipitation method is adopted for preparing superpara magnetism Fe3O4 nanoparticles, then, hexadecyl trimethyl ammonium bromide is used as a template, a photosensitizer is doped, accordingly, the surfaces of the magnetic nanoparticles and the photosensitizer are wrapped by a layer of mesoporous silica, covalent linkage and physical absorption of anti-cancer medicine are achieved, finally, surface modification is carried out through folic acid and hyaluronic acid, and the difunctional mesoporous silicon ball composite targeted drug delivery system is obtained. According to the system, multiple effects of nuclear magnetism radiography, fluorescence imaging, magnetic hyperthermia, photoactive therapy and chemotherapy are integrated, diagnosis and treatment are integrated, magnetic targeting and FA / HA dual receptor-mediated targeting effect can more effectively enhance the targeting combination of the medicine and tumor cells, the effective concentration of the medicine in the tumor parts is improved, effect enhancement and toxicity reduction are achieved, the killability for the cancer cells is enhanced through dual drug loading, and the treatment effect on tumors is remarkably improved. The product obtained through the preparation method has a quite large application prospect in the field of medicine control release.