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Biocompatible cross-linking micro-nano material for drug encapsulation and sustained release and preparation technology of biocompatible cross-linking micro-nano material for drug encapsulation and sustained release

A biocompatible, micro-nano technology, applied in the field of biocompatible cross-linked micro-nano materials for drug loading and sustained release and its construction technology, can solve threats, poor biocompatibility, environment and Human health hazards and other issues, to achieve the effect of easy storage, stable storage, and low energy consumption

Inactive Publication Date: 2017-02-15
WENZHOU INST OF BIOMATERIALS & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aldehyde condensation is a commonly used modification method for biomaterials with amino groups. The most commonly used aldehyde cross-linking agent is glutaraldehyde, but glutaraldehyde is flammable and explosive, which has certain effects on the environment and human health. hazards and threats
Moreover, the biomaterials cross-linked by glutaraldehyde will produce intermediates containing aldehyde groups after degradation in vivo, which will denature the proteins in the cells, thus making the biocompatibility of the materials worse

Method used

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  • Biocompatible cross-linking micro-nano material for drug encapsulation and sustained release and preparation technology of biocompatible cross-linking micro-nano material for drug encapsulation and sustained release
  • Biocompatible cross-linking micro-nano material for drug encapsulation and sustained release and preparation technology of biocompatible cross-linking micro-nano material for drug encapsulation and sustained release
  • Biocompatible cross-linking micro-nano material for drug encapsulation and sustained release and preparation technology of biocompatible cross-linking micro-nano material for drug encapsulation and sustained release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Take 4 tubes of 1 ml polyacrylate nanoparticles, add 0.1, 0.2, 0.4, 0.6 ml of 5% chitosan solution in sequence, mix for 1 hour and 3 hours at the same time, and centrifuge to separate the polyacrylate nanoparticles Particles, and the uncoated chitosan was washed with pure water, and after concentration, the polyacrylate nanoparticles were redispersed in phosphate (PPS) buffer for storage. Measure the particle size and potential before and after crosslinking with a particle size analyzer, and the results are shown in the attached figure 1 As shown, the particle size and surface potential of polyacrylate nanoparticles changed to varying degrees after encapsulation.

Embodiment 2

[0032] Example 2: Take 7 tubes of 1 ml polyacrylate microbubbles respectively, add 0.05, 0.1, 0.2, 0.4, 0.6, 0.8, 1.0 ml of 5% chitosan solution in sequence, and mix for 3 hours at the same time, then centrifuge to separate the microbubbles Bubble, and wash the uncoated chitosan with pure water, redisperse the polyacrylate microbubbles in phosphate (PPS) buffer after concentration, and store them. Measure particle size and potential before and after crosslinking with particle counter and particle size analyzer, the results are as attached figure 2 The particle size and potential of polyacrylate microbubbles changed to varying degrees after encapsulation.

Embodiment 3

[0033] Example 3: Take 5 tubes of 1 ml chitosan-wrapped polyacrylate nanoparticles, add 10, 50, 100, 250, 500 microliters of 0.1 moles per liter of genipin solution in sequence, and mix for 1 hour, 3 hours and 20 hours Finally, the polyacrylate nanoparticles were separated by centrifugation, and the uncrosslinked genipin was washed with pure water, and after concentration, the polyacrylate nanoparticles were redispersed in phosphate (PPS) buffer for storage. Measure the particle size and potential before and after crosslinking with a particle size analyzer, and the results are shown in the attached image 3 As shown, the particle size and surface potential of polyacrylate nanoparticles changed to varying degrees after crosslinking.

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Abstract

The invention discloses a biocompatible cross-linking micro-nano material for drug encapsulation and sustained release and a preparation technology of the biocompatible cross-linking micro-nano material for drug encapsulation and sustained release. A biological material takes polyacrylate microbubbles or nano particles as a matrix, chitosan as a coating material, genipin as a cross-linking agent and doxorubicin as a model drug, and drug encapsulation and release characteristics are investigated. The micro-nano material prepared according to the preparation technology has the advantages that the entrapment efficiency and the encapsulation efficiency are improved to a certain degree, and the in-vitro drug release speed can be controlled moderately. The preparation technology has the advantages of simple steps, mild conditions, technological environment friendliness, low energy consumption, no 'three wastes', no radiation and no noise, thereby being a universal technology for biocompatible cross-linking of micro-nano particles.

Description

technical field [0001] The invention relates to a biocompatible cross-linked micro-nano material for drug loading and sustained release and a construction process thereof. Background technique [0002] Surface encapsulation is one of the important methods for functional modification of micro-nanoparticles. After wrapping micro-nano particles with suitable materials, their size, surface charge, stability, expansion coefficient and many other properties will be changed to varying degrees compared with those before wrapping. At the same time, the encapsulation material can effectively endow micro-nano particles with specific biochemical properties, which facilitates the functional modification of micro-nano materials. However, the biocompatibility of the wrapping material will directly affect the bioactivity of the final micro-nano material, and the modifiability of the wrapping material determines the modification prospect of the micro-nano material. first condition. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/36A61K47/32C08J3/24C08L33/04C08L5/08
CPCA61K9/5138A61K9/5161A61K47/32A61K47/36C08J3/246C08J2333/04C08J2405/08A61K9/5036B01J13/14B01J13/22A61K9/5192C08J3/126C08J3/245
Inventor 刘哲徐齐恩陈莞尔
Owner WENZHOU INST OF BIOMATERIALS & ENG
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