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Nasal washing salt capable of providing nitric oxide and application thereof

A technology of nitric oxide and nasal washing, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, glycosylase, etc. Prominent and other problems, to achieve good efficacy and stability, inhibit bacterial growth, and improve the effect of rhinitis

Pending Publication Date: 2021-05-14
南京诺令生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the use of traditional Chinese medicine ingredients has the following disadvantages, (1) it is difficult to achieve drug efficacy, and the symptoms of treatment are not outstanding; (2) the preparation process is difficult, and the residual rate of magazines is high; (3) it is easy to increase the allergic chance of the patient's nasal cavity to Chinese medicine ingredients

Method used

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  • Nasal washing salt capable of providing nitric oxide and application thereof
  • Nasal washing salt capable of providing nitric oxide and application thereof
  • Nasal washing salt capable of providing nitric oxide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] This embodiment provides a kind of nasal washing salt and nasal washing liquid that can provide nitric oxide by itself. The composition and content of its raw materials are as follows:

[0060] NO donor material (0.0075 part of S-nitrosoglutathione, 0.0025 part of arginine), 0.9 part of osmotic pressure regulator (NaCl), catalyst (0.01 part of glutathione, 0.01 part of ascorbic acid), pH adjustment Agent (0.08 part of citric acid), antibacterial agent (0.05 part of sodium benzoate. After mixing the above-mentioned raw materials at 20° C. to obtain the nasal wash salt.

[0061] NO donor material (S-nitrosoglutathione 0.0075%, arginine 0.0025%), osmotic pressure regulator (NaCl) 0.9%, catalyst (glutathione 0.01%, ascorbic acid 0.01%), pH adjustment agent (citric acid 0.08%), antibacterial agent (sodium benzoate 0.05%), and the balance of purified water. The NO donor material, osmotic pressure regulator, catalyst, pH regulator, bacteriostatic agent and purified water were...

Embodiment 2

[0063] This embodiment provides a kind of nasal washing salt and nasal washing liquid that can provide nitric oxide by itself. The composition and content of its raw materials are as follows:

[0064] NO donor material (0.01 part of S-nitrosoglutathione, 0.005 part of arginine), 0.9 part of osmotic pressure regulator (NaCl), catalyst (0.005 part of glutathione, 0.01 part of ascorbic acid), pH adjustment agent (sodium citrate 0.2 parts), antibacterial agent (chitosan quaternary ammonium salt 0.1 part). The above-mentioned raw materials were mixed uniformly at 20° C. to obtain the nasal washing salt.

[0065] NO donor material (S-nitrosoglutathione 0.01%, arginine 0.005%), osmotic pressure regulator (NaCl) 0.9%, catalyst (glutathione 0.005%, ascorbic acid 0.01%), pH adjustment Agent (sodium citrate 0.2%), antibacterial agent (chitosan quaternary ammonium salt 0.1%), purified water balance. The NO donor material, osmotic pressure regulator, catalyst, pH regulator, bacteriostati...

Embodiment 3

[0067] This embodiment provides a kind of nasal washing salt and nasal washing liquid that can provide nitric oxide by itself. The composition and content of its raw materials are as follows:

[0068] NO donor material (0.008 part of S-nitrosoglutathione, 0.002 part of arginine), 0.9 part of osmotic pressure regulator (NaCl), catalyst (0.01 part of glutathione, 0.005 part of ascorbic acid), pH adjustment agent (0.1 part of disodium hydrogen phosphate), antibacterial agent (0.1 part of dodecyltrimethylammonium bromide). The above-mentioned raw materials were mixed uniformly at 20° C. to obtain the nasal washing salt.

[0069] NO donor material (S-nitrosoglutathione 0.008%, arginine 0.002%), osmotic pressure regulator (NaCl) 0.9%, catalyst (glutathione 0.01%, ascorbic acid 0.005%), pH adjustment agent (disodium hydrogen phosphate 0.1%), antibacterial agent (dodecyltrimethylammonium bromide 0.1%), and the balance of purified water. The NO donor material, osmotic pressure regula...

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Abstract

The invention relates to a nose washing salt capable of providing nitric oxide and application thereof. The nose washing salt is prepared from the following components in parts by weight: 0.001 to 0.1 part of an NO donor material, 0.5 to 1.5 parts of an osmotic pressure regulator, 0.001 to 0.05 part of a catalyst, 0.05 to 1 part of a pH regulator and 0.01 to 0.2 part of a bacteriostatic agent. According to the nasal washing salt, the above five components are combined according to a specific mass ratio, so the obtained nasal washing salt can spontaneously generate NO gas after being dissolved in water, and the NO gas can cause vasodilatation, capillary leakage and smooth muscle relaxation and stimulate gland secretion, so breathing is smoothed, bacterium breeding in a nasal cavity is inhibited, and the phenomena of rhinitis, sneezing, rhinorrhea and the like are obviously improved.

Description

technical field [0001] The invention belongs to the technical field of nasal washing materials, and relates to a nasal washing salt and an application thereof, in particular to a nasal washing salt capable of self-providing nitric oxide and an application thereof. Background technique [0002] Nitric oxide widely exists in various tissues and cells of the human body and has important physiological functions. Nitric oxide, also known as "vascular endothelial relaxation factor", can relax vascular smooth muscle and inhibit platelet aggregation. It can also act on adjacent peripheral neurons such as presynaptic nerve endings and astrocytes through diffusion, and reactivate Guanylate cyclase thus increases the level of cyclic guanosine monophosphate to produce physiological effects, such as inducing long-term potentiation effects related to learning and memory. Nitric oxide is also an effective broad-spectrum antibacterial and fungal agent. Normal nasal mucosal epithelial cells...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K38/47A61K9/08A61K9/46A61K47/26A61K47/18A61K47/22A61K47/02A61K47/12A61P11/02A61P31/04A61K31/192A61K31/085A61K31/14A61K31/722A61K31/045A61K31/60
CPCA61K33/00A61K31/192A61K31/085A61K31/14A61K31/722A61K31/045A61K31/60A61K38/47A61K9/08A61K9/0043A61K9/20A61K9/0007A61K47/26A61K47/183A61K47/22A61K47/02A61K47/12A61P11/02A61P31/04C12Y302/01017
Inventor 陆秋仙陈涛周林福毛雯
Owner 南京诺令生物科技有限公司
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